Phenotypes associated with this allele

• Allele Symbol: Ext1^tm1Dews
• Allele Name: targeted mutation 1, Dan E Wells
• Allele ID: MGI:1888710
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ext1^tm1Dews/Ext1^tm1Dews	involves: 129S7/SvEvBrd * C57BL/6	MGI:2171069
ht2	Ext1^tm1Dews/Ext1^+	involves: 129S7/SvEvBrd * C57BL/6	MGI:3848979

Genotype
MGI:2171069

hm1

• Allelic Composition: Ext1^tm1Dews/Ext1^tm1Dews
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:64021 )

• no homozygotes identified postnatally

• no live homozygous embryos identified after E8.5

• 80% have resorbed by E8.5 and remainder have poorly organized tissues

embryo

abnormal developmental patterning ( J:64021 )

decreased embryo size ( J:64021 )

• at E6.5

• increased somewhat by E7.5 but still significantly smaller than littermates

abnormal embryonic tissue morphology ( J:64021 )

• underdeveloped at E7.5

absent mesoderm ( J:64021 )

• no mesoderm development at E7.5

• remain as two layered cylinder of ectoderm and endoderm

failure of primitive streak formation ( J:64021 )

• no primitive streak or obvious head fold at E7.5

disorganized embryonic tissue ( J:64021 )

• at E8.5

abnormal extraembryonic tissue morphology ( J:64021 )

• extraembryonic region fails to develop by E6.5

• ectoplacental cone normal, attached to embryonic portion of embryos

growth/size/body

decreased embryo size ( J:64021 )

• at E6.5

• increased somewhat by E7.5 but still significantly smaller than littermates

Genotype
MGI:3848979

ht2

• Allelic Composition: Ext1^tm1Dews/Ext1⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

skeleton

abnormal skeleton morphology ( J:104933 )

• no observable bone deformities or exostoses at E14.5 or E18.5 no observable bone deformities or exostoses at E14.5 or E18.5

• humeri, femora, and tibias all normal in length an ossification at E18.5 although increased variability observed

abnormal long bone epiphyseal plate proliferative zone ( J:104933 )

• enlarged