Phenotypes associated with this allele

• Allele Symbol: Htr2b^tm1Lum
• Allele Name: targeted mutation 1, Luc Maroteaux
• Allele ID: MGI:1888735
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Htr2b^tm1Lum/Htr2b^tm1Lum	129S2/SvPas-Htr2b^tm1Lum	MGI:3604806

Genotype
MGI:3604806

hm1

• Allelic Composition: Htr2b^tm1Lum/Htr2b^tm1Lum
• Genetic Background: 129S2/SvPas-Htr2b^tm1Lum

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:64067 )

• second period of lethality in the first week of life

embryonic lethality during organogenesis, incomplete penetrance ( J:64067 )

• normal survival to E10.5

embryo

embryonic growth retardation ( J:64067 )

• seen in embryos surviving to E12.5 or longer

decreased embryo size ( J:64067 )

• growth retardation seen as early as E9.5

cardiovascular system

cardiovascular system phenotype ( J:79276 )

N • systolic blood pressure is normal under normal oxygen pressure

abnormal cardiovascular system morphology ( J:64067 )

disorganized myocardium ( J:64067 )

• myocellular disorganization in 6 week old adults

abnormal heart development ( J:64067 )

• heart enlarged at E9.5 defects in subepicardial layer of heart and lack of trabecular cells in ventricle

• premature differentiation of sarcomeres in the heart at E9.5

dilated heart atrium ( J:64067 )

• dilated heart chambers at 6 weeks of age

decreased heart weight ( J:64067 )

• heart weight/body weight ratio reduced by about 28%

abnormal heart ventricle morphology ( J:64067 , J:79276 )

• considerable decrease in ventricular mass in newborns (J:64067)

• dilated heart chambers at 6 weeks of age (J:64067)

• fails to develop right ventricular hypertrophy in response to chronic hypoxia (J:79276)

absent trabeculae carneae ( J:64067 )

• lack of trabecular cells in embryonic ventricle

abnormal cardiovascular system physiology ( J:79276 )

abnormal fetal cardiomyocyte proliferation ( J:64067 )

• loss of proliferative capacity of the heart at birth

decreased right ventricle systolic pressure ( J:79276 )

• fail to respond Chronically to hypoxia with an increase in right ventricular systolic blood pressure although short term responses are normal

growth/size/body

embryonic growth retardation ( J:64067 )

• seen in embryos surviving to E12.5 or longer

decreased embryo size ( J:64067 )

• growth retardation seen as early as E9.5

decreased body weight ( J:64067 )

• body weight reduced by about 9%

reproductive system

reduced fertility ( J:64067 )

muscle

absent trabeculae carneae ( J:64067 )

• lack of trabecular cells in embryonic ventricle

disorganized myocardium ( J:64067 )

• myocellular disorganization in 6 week old adults

abnormal fetal cardiomyocyte proliferation ( J:64067 )

• loss of proliferative capacity of the heart at birth

cellular

abnormal fetal cardiomyocyte proliferation ( J:64067 )

• loss of proliferative capacity of the heart at birth