Phenotypes associated with this allele

• Allele Symbol: Tcf21^tm1Eno
• Allele Name: targeted mutation 1, Eric N Olson
• Allele ID: MGI:1888738
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcf21^tm1Eno/Tcf21^tm1Eno	involves: 129 * Black Swiss	MGI:2174756

Genotype
MGI:2174756

hm1

• Allelic Composition: Tcf21^tm1Eno/Tcf21^tm1Eno
• Genetic Background: involves: 129 * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:64068 )

• homozygotes are born alive but die within 5-10 min after birth

homeostasis/metabolism

cyanosis ( J:64068 )

• homozygotes become cyanotic shortly after birth

respiratory system

abnormal branching involved in lung morphogenesis ( J:64068 )

• mutant lung epithelia fail to undergo branching morphogenesis

pulmonary hypoplasia ( J:64068 )

• mutant lungs are severely hypoplastic

absent pulmonary alveoli ( J:64068 )

• homozygotes show absence of respiratory alveoli

respiratory distress ( J:64068 )

• newborn homozygotes have difficulty in breathing and display gasping motions

hematopoietic system

abnormal spleen development ( J:64068 )

• splenic precursors are specified, as shown by normal expression of early markers of spleen development in the splenic anlage at E12.5; however, the mutant splenic anlage fails to expand and, in its absence, the splenic primordium undergoes apoptotic cell death

absent spleen ( J:64068 )

• newborn homozygotes display complete absence of a spleen

• in contrast, the stomach and pancreas are properly located

renal/urinary system

renal glomerulus atrophy ( J:64068 )

• homozygotes display atrophic kidney glomeruli

abnormal kidney development ( J:64068 )

renal hypoplasia ( J:64068 )

• mutant kidneys are severely hypoplastic

impaired branching involved in ureteric bud morphogenesis ( J:64068 )

• mutant kidney epithelia fail to undergo branching morphogenesis

immune system

abnormal spleen development ( J:64068 )

• splenic precursors are specified, as shown by normal expression of early markers of spleen development in the splenic anlage at E12.5; however, the mutant splenic anlage fails to expand and, in its absence, the splenic primordium undergoes apoptotic cell death

absent spleen ( J:64068 )

• newborn homozygotes display complete absence of a spleen

• in contrast, the stomach and pancreas are properly located

integument

pallor ( J:64068 )

• homozygotes become pale shortly after birth