Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nf2tm1Gth targeted mutation 1, Gilles Thomas MGI:1888776 |
||||||||||||||||||||||||||||||||
| Summary |
7 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 13% of mice exhibit fibroadenoma in the mammary gland
|
|
• 13% of mice exhibit fibroadenoma in the mammary gland
|
|
• mice exhibit osseous metaplasia in the lung, brain, kidney, and nasal mucosa
|
|
• 6% of mice develop neurofibroma
|
|
• in 56% in mice
|
|
• 6% of mice develop anaplastic carcinoma in the kidney
|
|
• 13% of mice develop carcino-sarcoma in the mammary gland
|
|
• 6% of mice develop neurofibrosarcoma with 2 of 7 metastasizing to the liver
|
|
• in 44% of mice
|
|
• 6% of mice develop mesothelioma
|
|
• 50% of mice develop osteoma
|
|
• 13% of mice exhibit fibroadenoma in the mammary gland
|
|
• 6% of mice exhibit odontoblastic hyperplasia
|
|
• in 44% of mice
|
|
• 50% of mice develop osteoma
|
|
• osteoblastic hyperplasia in 44% of mice
|
|
• 6% of mice develop anaplastic carcinoma in the kidney
|
|
• 38% of mice exhibit renal tubular cell hyperplasia
|
|
• in 56% in mice
|
| N |
• mice exhibit normal Schwann cell proliferation
|
|
• 6% of mice develop neurofibroma
|
|
• 6% of mice develop neurofibrosarcoma with 2 of 7 metastasizing to the liver
|
|
• 6% of mice exhibit odontoblastic hyperplasia
|
|
• 6% of mice exhibit odontoblastic hyperplasia
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit reduced viability
|
|
• mice exhibit osseous metaplasia in the lung, brain, kidney, and nasal mucosa
|
|
• one mouse developed a mesothelioma
|
|
• 9% of mice develop odontomas and odontosarcomas
|
|
• 9% of mice develop odontomas and odontosarcomas
|
|
• mice develop Schwann cell tumors
|
|
• mice exhibit odontoblastic hyperplasia
|
|
• osteoblastic hyperplasia
|
|
• mice develop Schwann cell tumors
|
|
• 59% of mice exhibit Schwann cell hyperplasia
|
|
• mice exhibit renal tubular cell hyperplasia
|
|
• mice exhibit odontoblastic hyperplasia
|
|
• mice exhibit odontoblastic hyperplasia
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 50% of mice die within the first year
|
|
• retarded or absent
|
|
• retarded or absent
|
|
• retarded or absent
|
|
• retarded or absent
|
|
• retarded or absent
|
|
• retarded or absent
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| otitis media | DOID:10754 | J:63264 | ||
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the few mice that are produced die prior to weaning
|
|
• at P17, one mouse exhibited a subcutaneous Schwann cell nodule
|
|
• at P19, one mouse exhibited a hamartoma of the olfactory bulb composed of Schwann and neural cells
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/10/2024 MGI 6.24 |
|
|
|
||
