Analysis Tools
neoplasm
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• about half of mutants develop tumors originating from the intermediate lobe by 12 weeks of age
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pigmentation
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• the pigment epithelium layer was thickened and cells composing it were taller than normal
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endocrine/exocrine glands
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• marked hyperplasia of the medulla however the cortex remained normal
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• weight of pituitary was more than 2-fold that of wildtype
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• intermediate lobes were hyperplastic while the anterior and posterior lobes were relatively normal
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• about half of mutants develop tumors originating from the intermediate lobe by 12 weeks of age
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• thymus sometimes totally covered the heart
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• elevated number of of thymocytes
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• formation of corpus luteum was not seen at 12 weeks of age
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• marked accumulation of atypical follicles with extensive hyperplasia of granulosa cells, whereas theca cells remained normal
• follicles contained fewer apoptotic cells and degenerative granulosa cells than in control atretic follicles
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• atypical follicles with extensive hyperplasia of granulosa cells
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• no evidence of Graafian follicles in ovaries
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• most of the accumulated follicles were primary and secondary follicles, but further development was impaired
• formation of the cavity (antrum) was much less prominent than in controls
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• ovary was 2-fold larger than in controls
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• testis was 2-fold larger than in controls
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growth/size/body
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• ovary was 2-fold larger than in controls
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• weight of organs increased in proportion to the whole body weight, except for a few enlarged organs
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• by 4-6 weeks of age, weigh more than controls with the weight difference becoming more pronounced with age, however did not gain weight faster than controls
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hematopoietic system
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• thymus sometimes totally covered the heart
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• elevated number of of thymocytes
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• some mutants contained 2-fold more T cells in the spleen and lymph notes, however number of B cells was normal
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immune system
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• thymus sometimes totally covered the heart
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• elevated number of of thymocytes
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• some mutants contained 2-fold more T cells in the spleen and lymph notes, however number of B cells was normal
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reproductive system
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• formation of corpus luteum was not seen at 12 weeks of age
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• marked accumulation of atypical follicles with extensive hyperplasia of granulosa cells, whereas theca cells remained normal
• follicles contained fewer apoptotic cells and degenerative granulosa cells than in control atretic follicles
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• atypical follicles with extensive hyperplasia of granulosa cells
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• no evidence of Graafian follicles in ovaries
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• most of the accumulated follicles were primary and secondary follicles, but further development was impaired
• formation of the cavity (antrum) was much less prominent than in controls
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• ovary was 2-fold larger than in controls
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• testis was 2-fold larger than in controls
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• endometrium and interstitial tissue of the uterus were always hyperplastic
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• endometrium of the uterus was always hyperplastic
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vision/eye
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• increase in Mullers supporting cells in the inner granular layer
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• increase in amacrine cells in the inner granular layer
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• partial loss of the rod and cone layer
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• the pigment epithelium layer was thickened and cells composing it were taller than normal
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• the outer granular layer invaded the layer of rods and cones beyond the outer limiting membrane
• the inner granular layer exhibited a displacement of bipolar cells, with an increase in the number of amacrine cells and Mullers supporting cells, and a disorganization of the network of cell fibers
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• the outer limiting membrane was irregular and not clearly recognizable
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• variable reduction in electroretinographic (ERG) amplitudes
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nervous system
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• weight of pituitary was more than 2-fold that of wildtype
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• intermediate lobes were hyperplastic while the anterior and posterior lobes were relatively normal
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• about half of mutants develop tumors originating from the intermediate lobe by 12 weeks of age
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• increase in Mullers supporting cells in the inner granular layer
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• increase in amacrine cells in the inner granular layer
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• partial loss of the rod and cone layer
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