Phenotypes associated with this allele

• Allele Symbol: Fli1^tm1Adh
• Allele Name: targeted mutation 1, Adam Hart
• Allele ID: MGI:1888942
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fli1^tm1Adh/Fli1^tm1Adh	either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	MGI:2652228

Genotype
MGI:2652228

hm1

• Allelic Composition: Fli1^tm1Adh/Fli1^tm1Adh
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:64178 )

• most die at E11.5 and E12.5, with no homozygous embryos detected at E15

hematopoietic system

abnormal megakaryocyte morphology ( J:64178 )

• E11.5 liver megakaryocytes exhibit reduced numbers of alpha granules, disorganization of the platelet demarcation membranes, and reduced size

abnormal megakaryocyte progenitor cell morphology ( J:64178 )

• megakaryocyte progenitors derived from E11.5 livers were increased in number and compromised in their capacity to differentiate

cardiovascular system

abnormal vascular development ( J:64178 )

• loss of vascular integrity leading to bleeding within the vascular plexus of the cerebral meninges

intracranial hemorrhage ( J:64178 )

• intracranial hemorrhaging in the midbrain/forebrain boundary and in the hindbrain between E9.5 and E11.5 and multifocal intracranial hemorrhages begin to appear at E11.5-E12.5

nervous system

intracranial hemorrhage ( J:64178 )

• intracranial hemorrhaging in the midbrain/forebrain boundary and in the hindbrain between E9.5 and E11.5 and multifocal intracranial hemorrhages begin to appear at E11.5-E12.5

abnormal brain meninges morphology ( J:64178 )

• endothelial cells of the forebrain meninges appear attenuated and discontinuous