Phenotypes associated with this allele

• Allele Symbol: Camk4^tm1Tch
• Allele Name: targeted mutation 1, Talal A Chatila
• Allele ID: MGI:1888972
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camk4^tm1Tch/Camk4^tm1Tch	B6.129X1-Camk4^tm1Tch	MGI:3794864
hm2	Camk4^tm1Tch/Camk4^tm1Tch	involves: 129X1/SvJ * C57BL/6	MGI:3794860

Genotype
MGI:3794864

hm1

• Allelic Composition: Camk4^tm1Tch/Camk4^tm1Tch
• Genetic Background: B6.129X1-Camk4^tm1Tch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:122984 )

• memory for increased vestibuloocular reflex gain is impaired compared to in wild-type mice regardless of spaced training

• however, vestibuloocular reflex, motor function and optokinetic reflex are normal and reduced training stimulus frequency rescues memory of increased vestibuloocular reflex gain

impaired conditioned place preference behavior ( J:108062 )

• mice spend less time exploring the morphine-paired side of the chamber than wild-type mice

• however, initial place preference and withdrawal behaviors are normal

decreased chemically-elicited antinociception ( J:108062 )

• mice exhibit less analgesic tolerance after chronic morphine treatment compared to wild-type mice

skeleton

abnormal osteoclast differentiation ( J:129599 )

• osteoclastognesis induced by RANKL is suppressed unlike in wild-type mice

decreased osteoclast cell number ( J:129599 )

increased bone mineral density ( J:129599 )

increased bone volume ( J:129599 )

• bone volume is increased compared to in wild-type mice

abnormal bone remodeling ( J:129599 )

• LPS-induced bone erosion is reduced compared to in wild-type mice

nervous system

abnormal inhibitory postsynaptic currents ( J:108062 )

• pre-exposure to morphine fails to abolish the morphine-induced decrease in inhibitory postsynaptic current as in wild-type mice

immune system

abnormal osteoclast differentiation ( J:129599 )

• osteoclastognesis induced by RANKL is suppressed unlike in wild-type mice

decreased osteoclast cell number ( J:129599 )

hematopoietic system

abnormal osteoclast differentiation ( J:129599 )

• osteoclastognesis induced by RANKL is suppressed unlike in wild-type mice

decreased osteoclast cell number ( J:129599 )

cellular

abnormal osteoclast differentiation ( J:129599 )

• osteoclastognesis induced by RANKL is suppressed unlike in wild-type mice

Genotype
MGI:3794860

hm2

• Allelic Composition: Camk4^tm1Tch/Camk4^tm1Tch
• Genetic Background: involves: 129X1/SvJ * C57BL/6

nervous system

nervous system phenotype ( J:64210 )

N • mice exhibit normal neuroanatomy

abnormal Purkinje cell dendrite morphology ( J:64210 )

• Purkinje neuron dendritic arbors appear reduced compared to wild-type neurons in culture

abnormal excitatory postsynaptic currents ( J:64210 )

• the R input is increased by 250% compared to in wild-type mice

decreased excitatory postsynaptic current frequency ( J:64210 )

• the frequency of miniature excitatory postsynaptic currents is reduced by 70%

reduced long-term depression ( J:64210 )

• long term depression is impaired

behavior/neurological

behavior/neurological phenotype ( J:64210 )

N • mice exhibit normal spatial memory

abnormal locomotor activation ( J:64210 )

• while locomotion and sensorimotor functions are normal, mice take longer to initiate movement compared to wild-type mice