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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ackr1tm1Scp
targeted mutation 1, Stephen C Peiper
MGI:1888977
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ackr1tm1Scp/Ackr1tm1Scp involves: 129P2/OlaHsd MGI:4819817
hm2
 		Ackr1tm1Scp/Ackr1tm1Scp involves: 129P2/OlaHsd * C57BL/6 MGI:3618756
cx3
 		Cxcl5tm1Gscw/Cxcl5tm1Gscw
Ackr1tm1Scp/Ackr1tm1Scp 		involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:4819818


Genotype
MGI:4819817
hm1
Allelic
Composition		 Ackr1tm1Scp/Ackr1tm1Scp
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ackr1tm1Scp mutation (1 available); any Ackr1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal circulating chemokine level ( J:162629 )
• after incubation of the citrated blood, plasma concentrations of CXCL1 and CXCL5 are increased compared to in the plasma of similarly treated wild-type mice

immune system
abnormal circulating chemokine level ( J:162629 )
• after incubation of the citrated blood, plasma concentrations of CXCL1 and CXCL5 are increased compared to in the plasma of similarly treated wild-type mice




Genotype
MGI:3618756
hm2
Allelic
Composition		 Ackr1tm1Scp/Ackr1tm1Scp
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ackr1tm1Scp mutation (1 available); any Ackr1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased inflammatory response ( J:64222 )
• homozygotes are viable, fertile, and apparently healthy up to 1 year of age, with normal hematologic profiles relative to wild-type mice
• however, at 2 hrs after i.p. injection of LPS (30 mg/kg), homozygotes display an exaggerated inflammatory response with a significantly increased accumulation of leukocytes and neutrophils in lung and liver




Genotype
MGI:4819818
cx3
Allelic
Composition		 Cxcl5tm1Gscw/Cxcl5tm1Gscw
Ackr1tm1Scp/Ackr1tm1Scp
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ackr1tm1Scp mutation (1 available); any Ackr1 mutation (24 available)
Cxcl5tm1Gscw mutation (0 available); any Cxcl5 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal circulating chemokine level ( J:162629 )
• mice exhibit increased chemokine scavenging compared with wild-type mice although not as severe as in Darctm1Scp homozygotes

immune system
abnormal circulating chemokine level ( J:162629 )
• mice exhibit increased chemokine scavenging compared with wild-type mice although not as severe as in Darctm1Scp homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory