Phenotypes associated with this allele

• Allele Symbol: Mtor^flat
• Allele Name: flat-top
• Allele ID: MGI:1889297
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtor^flat/Mtor^flat	involves: BTBR/J * C57BL/6J	MGI:3521581
hm2	Mtor^flat/Mtor^flat	Not Specified	MGI:3521582

Genotype
MGI:3521581

hm1

• Allelic Composition: Mtor^flat/Mtor^flat
• Genetic Background: involves: BTBR/J * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:53291 )

• mutant embryos begin to die around E11.5

embryo

incomplete embryo turning ( J:53291 )

• after E8.5 embryos fail to turn

embryonic growth retardation ( J:53291 )

• a developmental delay of 2-5 somites is seen

decreased embryo size ( J:53291 )

• mutant embryos are 60-70% of the size of somite number matched wild-type embryos

abnormal embryonic neuroepithelium morphology ( J:53291 )

• at about E10.5 buckling of the neuroepithelium in the forebrain is seen

growth/size/body

embryonic growth retardation ( J:53291 )

• a developmental delay of 2-5 somites is seen

decreased embryo size ( J:53291 )

• mutant embryos are 60-70% of the size of somite number matched wild-type embryos

nervous system

abnormal embryonic neuroepithelium morphology ( J:53291 )

• at about E10.5 buckling of the neuroepithelium in the forebrain is seen

abnormal midbrain morphology ( J:53291 )

• constrictions between the midbrain and caudal diencephalon are more prominent than normal

abnormal forebrain morphology ( J:53291 )

• at about E10.5 buckling of the neuroepithelium in the forebrain is seen

absent embryonic telencephalon ( J:53291 )

• the telencephalic vesicles fail to form

forebrain hypoplasia ( J:53291 )

• proliferation of cells in the forebrain is reduced compared to wild-type embryos

abnormal diencephalon morphology ( J:53291 )

• constrictions between the rostral and caudal diencephalon are more prominent than normal

Genotype
MGI:3521582

hm2

• Allelic Composition: Mtor^flat/Mtor^flat
• Genetic Background: Not Specified

embryo

incomplete embryo turning ( J:94381 )

• mutant embryos fail to turn

embryonic growth arrest ( J:94381 )

• growth arrest is seen around E10.5

embryonic growth retardation ( J:94381 )

decreased embryo size ( J:94381 )

• mutant embryos are smaller than somite number matched wild-type embryos

abnormal embryonic tissue morphology ( J:94381 )

• at E9.5 the midthoracic region contains one third fewer cells compared to wild-type embryos, however the distribution of cell sizes is normal

growth/size/body

embryonic growth retardation ( J:94381 )

decreased embryo size ( J:94381 )

• mutant embryos are smaller than somite number matched wild-type embryos

nervous system

absent embryonic telencephalon ( J:94381 )

• the telencephalon is missing