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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bsp
black spleen
MGI:1889301
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bsp/Bsp C57BL/6By MGI:2658853
ht2
 		Bsp/Bsp+ C57BL/6By MGI:2658854


Genotype
MGI:2658853
hm1
Allelic
Composition		 Bsp/Bsp
Genetic
Background		 C57BL/6By
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
lipofuscinosis ( J:6856 )
• Background Sensitivity: lipofuscin (black pigment)in the anterior end of the spleen is seen in mice on different C57BL backgrounds but is not observed in lines not derived from C57BL
• does not occur in albino mice or mice homozygous for Oca2, a pigment dilution mutation, indicating that lipofuscin and melanin pigment share a pathway
• found in 4 to 50% of mice of C57BL sublines

hematopoietic system
abnormal spleen morphology ( J:6856 )
• Background Sensitivity: lipofuscin (black pigment) is found in the anterior end of the spleen of mice from C57BL sublines but not in mice from lines not derived from C57BL

immune system
abnormal spleen morphology ( J:6856 )
• Background Sensitivity: lipofuscin (black pigment) is found in the anterior end of the spleen of mice from C57BL sublines but not in mice from lines not derived from C57BL




Genotype
MGI:2658854
ht2
Allelic
Composition		 Bsp/Bsp+
Genetic
Background		 C57BL/6By
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
lipofuscinosis ( J:6856 )
• Background Sensitivity: lipofuscin (black pigment) is found the anterior end of the spleen is seen in mice in different C57BL sublines but is not observed in lines not derived from C57BL
• F1 offspring between a C57BL parent and other strains with lipofuscinosis have black spleens in about the same percentage as the C57BL parent

hematopoietic system
abnormal spleen morphology ( J:6856 )
• Background Sensitivity: lipofuscin (black pigment) is found the anterior end of the spleen of mice from C57BL sublines but not in mice from lines not derived from C57BL

immune system
abnormal spleen morphology ( J:6856 )
• Background Sensitivity: lipofuscin (black pigment) is found the anterior end of the spleen of mice from C57BL sublines but not in mice from lines not derived from C57BL




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory