Phenotypes associated with this allele

• Allele Symbol: Mdga2^Adp
• Allele Name: acrodysplasia
• Allele ID: MGI:1889308
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mdga2^Adp/Mdga2^+	involves: C57BL/6J * DBA/2	MGI:5313463

Genotype
MGI:5313463

ht1

• Allelic Composition: Mdga2^Adp/Mdga2⁺
• Genetic Background: involves: C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal limb bud morphology ( J:82720 )

• at E13.5, limb buds are more polygonal than round when this allele is inherited paternally

• however, the apical ectodermal ridge is intact

abnormal autopod morphology ( J:82720 , J:181260 )

• when this allele is inherited paternally (J:82720)

• when this allele is inherited paternally with varying degrees of severity depending on methylation status of the gene (J:181260)

abnormal carpal bone morphology ( J:82720 )

• not ossified in the fore paws of newborns when this allele is inherited paternally

abnormal digit development ( J:82720 )

• no distinct digit formation in the fore paws of some mice when this allele is inherited paternally

abnormal tail morphology ( J:22176 )

embryo

abnormal limb bud morphology ( J:82720 )

• at E13.5, limb buds are more polygonal than round when this allele is inherited paternally

• however, the apical ectodermal ridge is intact

craniofacial

narrow snout ( J:181260 )

• shorter and narrower when this allele is inherited paternally

short snout ( J:181260 )

• shorter and narrower when this allele is inherited paternally

skeleton

abnormal carpal bone morphology ( J:82720 )

• not ossified in the fore paws of newborns when this allele is inherited paternally

synostosis ( J:82720 )

• in some of the autopod small bones when this allele is inherited paternally

cellular

abnormal DNA methylation ( J:181260 )

• when this allele is inherited paternally, mice exhibit abnormal autopod morphology with varying degrees of severity depending on methylation status of the gene

growth/size/body

narrow snout ( J:181260 )

• shorter and narrower when this allele is inherited paternally

short snout ( J:181260 )

• shorter and narrower when this allele is inherited paternally