Analysis Tools
mortality/aging
growth/size/body
|
• small size is noticeable by 12 days of age
|
|
• mutants weigh 50% less than control littermates
|
behavior/neurological
limb grasping
(
J:60439
)
|
• when picked up the tail, the rear legs are held in an extended position for a brief period and then the legs clasp
|
|
• rear legs are overextended when sitting and extend beyond the front legs when walking
|
|
• mutants have problems maintaining their balance and appear to prop themselves up in the shavings or against the cage wall when sitting
• when placed in water, mutants cannot orient body position and go to the bottom of the container in a rolling spiral
|
abnormal gait
(
J:60439
)
paraparesis
(
J:60439
)
|
• weakness in the hindlimbs that causes mutant to fall to one side and then the other
|
homeostasis/metabolism
|
• significantly reduced blood glucose
|
nervous system
| N |
• although the behavioral abnormalities appear similar to mice that have cerebellum abnormalities, brain sections reveal no abnormalities, especially in the cerebellum
|
muscle
| N |
• skeletal muscle shows no muscular dystrophy or neurogenic atrophy
|
hearing/vestibular/ear
| N |
• normal hearing and ears
|
