Phenotypes associated with this allele

• Allele Symbol: Tg(AMY1C)9257Mm
• Allele Name: transgene insertion 9257, Miriam Meisler
• Allele ID: MGI:1889519
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(AMY1C)9257Mm/Tg(AMY1C)9257Mm	involves: C3H * C57BL/6J	MGI:2174814
tg2	Tg(AMY1C)9257Mm/Tg(AMY1C)9257Mm	involves: C57BL/6J * DBA/2J	MGI:3689921
tg3	Tg(AMY1C)9257Mm/0	involves: C3H * C57BL/6J	MGI:2174815
tg4	Tg(AMY1C)9257Mm/0	involves: C57BL/6J * DBA/2J	MGI:3689920

Genotype
MGI:2174814

tg1

• Allelic Composition: Tg(AMY1C)9257Mm/Tg(AMY1C)9257Mm
• Genetic Background: involves: C3H * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:16317 )

• no homozygous mice are found at E17.5 with no evidence of resorbed embryos, suggesting an early embryonic lethality

Genotype
MGI:3689921

tg2

• Allelic Composition: Tg(AMY1C)9257Mm/Tg(AMY1C)9257Mm
• Genetic Background: involves: C57BL/6J * DBA/2J

mortality/aging

preweaning lethality, incomplete penetrance ( J:59841 )

• at 2 weeks of age, fewer than expected homozygotes are present

growth/size/body

abnormal nose morphology ( J:59841 )

• dysplastic lateral nasal wall development

short nasal bone ( J:59841 )

abnormal turbinate morphology ( J:59841 )

• nasal turbinates are small and asymmetric

deviated nasal septum ( J:59841 )

• lateral deviation of the cartilagenous nasal septum

abnormal olfactory epithelium morphology ( J:59841 )

• disorganized and thin

decreased body weight ( J:59841 )

• animals weigh less than controls

vision/eye

abnormal eye morphology ( J:59841 )

• 60% of mice exhibit eye defects that are variable and range in severity, with defects appearing either unilaterally or bilaterally

abnormal lens fiber morphology ( J:59841 )

• elongation of lens fibers is distorted

small lens ( J:59841 )

• lens size is reduced at E12.5 and greatly reduced by E14.5

abnormal eye development ( J:59841 )

• at E14.5, the neural retina is folded upon itself and is thick

abnormal lens development ( J:59841 )

• delayed closure of the lens cup at E10.5

abnormal optic cup morphology ( J:59841 )

• delayed invagination of the optic cup at E10.5

• increased numbers of mesenchymal cells in the space between the optic cup and lens at E10.5; this number increased until E14.5, when they fill the hyaloid cavity

microphthalmia ( J:59841 )

anophthalmia ( J:59841 )

respiratory system

abnormal nose morphology ( J:59841 )

• dysplastic lateral nasal wall development

short nasal bone ( J:59841 )

abnormal turbinate morphology ( J:59841 )

• nasal turbinates are small and asymmetric

deviated nasal septum ( J:59841 )

• lateral deviation of the cartilagenous nasal septum

abnormal olfactory epithelium morphology ( J:59841 )

• disorganized and thin

taste/olfaction

taste/olfaction phenotype ( J:59841 )

N • mice appear to have no defect in olfactory function

abnormal olfactory epithelium morphology ( J:59841 )

• disorganized and thin

nervous system

abnormal olfactory nerve morphology ( J:59841 )

• reduction in number and size of nerve terminals in the olfactory epithelium

hearing/vestibular/ear

absent lateral semicircular canal ( J:59841 )

• canals are absent at E14.5

craniofacial

abnormal neurocranium morphology ( J:59841 )

• reduced overall length

short frontal bone ( J:59841 )

abnormal sphenoid bone morphology ( J:59841 )

• short

short premaxilla ( J:59841 )

short maxilla ( J:59841 )

abnormal palatine bone morphology ( J:59841 )

• short

abnormal nose morphology ( J:59841 )

• dysplastic lateral nasal wall development

short nasal bone ( J:59841 )

abnormal turbinate morphology ( J:59841 )

• nasal turbinates are small and asymmetric

deviated nasal septum ( J:59841 )

• lateral deviation of the cartilagenous nasal septum

abnormal olfactory epithelium morphology ( J:59841 )

• disorganized and thin

skeleton

abnormal neurocranium morphology ( J:59841 )

• reduced overall length

short frontal bone ( J:59841 )

abnormal sphenoid bone morphology ( J:59841 )

• short

short premaxilla ( J:59841 )

short maxilla ( J:59841 )

short nasal bone ( J:59841 )

abnormal palatine bone morphology ( J:59841 )

• short

abnormal turbinate morphology ( J:59841 )

• nasal turbinates are small and asymmetric

Genotype
MGI:2174815

tg3

• Allelic Composition: Tg(AMY1C)9257Mm/0
• Genetic Background: involves: C3H * C57BL/6J

behavior/neurological

impaired swimming ( J:16317 )

• affected mice are unable to remain at the surface of water for more than 1-2 minutes

hyperactivity ( J:16317 )

bidirectional circling ( J:16317 )

craniofacial

decreased cranium length ( J:16317 )

• skull length is reduced by 10%

abnormal frontal bone morphology ( J:16317 )

abnormal premaxilla morphology ( J:16317 )

absent maxilla ( J:16317 )

short nasal bone ( J:16317 )

• length is approximately 75% of controls

abnormal turbinate morphology ( J:16317 )

abnormal nasal septum morphology ( J:16317 )

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:16317 )

N • normal Preyer's reflex and normal auditory brain stem responses are seen suggesting that mice are not deaf

N • vestibular apparatus appeared normal with normal utricle and sacculi as well as the associated maculae and otoliths

decreased lateral semicircular canal size ( J:16317 )

• dramatic reduction in the horizontal canal

abnormal crista ampullaris morphology ( J:16317 )

• lack the usual convex shape and evagination; appear flattened in the horizontal canal and to a lesser extent in the posterior and anterior canals

skeleton

decreased cranium length ( J:16317 )

• skull length is reduced by 10%

abnormal frontal bone morphology ( J:16317 )

abnormal premaxilla morphology ( J:16317 )

absent maxilla ( J:16317 )

short nasal bone ( J:16317 )

• length is approximately 75% of controls

abnormal turbinate morphology ( J:16317 )

respiratory system

short nasal bone ( J:16317 )

• length is approximately 75% of controls

abnormal turbinate morphology ( J:16317 )

abnormal nasal septum morphology ( J:16317 )

growth/size/body

short nasal bone ( J:16317 )

• length is approximately 75% of controls

abnormal turbinate morphology ( J:16317 )

abnormal nasal septum morphology ( J:16317 )

Genotype
MGI:3689920

tg4

• Allelic Composition: Tg(AMY1C)9257Mm/0
• Genetic Background: involves: C57BL/6J * DBA/2J

vision/eye

abnormal eye morphology ( J:59841 )

• 6% of animals exhibit eye defects that are variable and range in severity, with defects appearing either unilaterally or bilaterally

respiratory system

abnormal nose morphology ( J:59841 )

• dysplastic lateral nasal wall development

deviated nasal septum ( J:59841 )

• lateral deviation of the cartilagenous nasal septum

craniofacial

abnormal nose morphology ( J:59841 )

• dysplastic lateral nasal wall development

deviated nasal septum ( J:59841 )

• lateral deviation of the cartilagenous nasal septum

growth/size/body

abnormal nose morphology ( J:59841 )

• dysplastic lateral nasal wall development

deviated nasal septum ( J:59841 )

• lateral deviation of the cartilagenous nasal septum