Analysis Tools
mortality/aging
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• no homozygous mice are found at E17.5 with no evidence of resorbed embryos, suggesting an early embryonic lethality
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Allele Symbol Allele Name Allele ID |
Tg(AMY1C)9257Mm transgene insertion 9257, Miriam Meisler MGI:1889519 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no homozygous mice are found at E17.5 with no evidence of resorbed embryos, suggesting an early embryonic lethality
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 2 weeks of age, fewer than expected homozygotes are present
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• dysplastic lateral nasal wall development
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• nasal turbinates are small and asymmetric
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• lateral deviation of the cartilagenous nasal septum
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• disorganized and thin
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• animals weigh less than controls
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• 60% of mice exhibit eye defects that are variable and range in severity, with defects appearing either unilaterally or bilaterally
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• elongation of lens fibers is distorted
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• lens size is reduced at E12.5 and greatly reduced by E14.5
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• at E14.5, the neural retina is folded upon itself and is thick
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• delayed closure of the lens cup at E10.5
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• delayed invagination of the optic cup at E10.5
• increased numbers of mesenchymal cells in the space between the optic cup and lens at E10.5; this number increased until E14.5, when they fill the hyaloid cavity
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• dysplastic lateral nasal wall development
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• nasal turbinates are small and asymmetric
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• lateral deviation of the cartilagenous nasal septum
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• disorganized and thin
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| N |
• mice appear to have no defect in olfactory function
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• disorganized and thin
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• reduction in number and size of nerve terminals in the olfactory epithelium
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• canals are absent at E14.5
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• reduced overall length
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• short
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• short
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• dysplastic lateral nasal wall development
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• nasal turbinates are small and asymmetric
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• lateral deviation of the cartilagenous nasal septum
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• disorganized and thin
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• reduced overall length
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• short
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• short
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• nasal turbinates are small and asymmetric
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• affected mice are unable to remain at the surface of water for more than 1-2 minutes
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• skull length is reduced by 10%
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• length is approximately 75% of controls
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| N |
• normal Preyer's reflex and normal auditory brain stem responses are seen suggesting that mice are not deaf
• vestibular apparatus appeared normal with normal utricle and sacculi as well as the associated maculae and otoliths
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• dramatic reduction in the horizontal canal
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• lack the usual convex shape and evagination; appear flattened in the horizontal canal and to a lesser extent in the posterior and anterior canals
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• skull length is reduced by 10%
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• length is approximately 75% of controls
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• length is approximately 75% of controls
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• length is approximately 75% of controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 6% of animals exhibit eye defects that are variable and range in severity, with defects appearing either unilaterally or bilaterally
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• dysplastic lateral nasal wall development
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• lateral deviation of the cartilagenous nasal septum
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• dysplastic lateral nasal wall development
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• lateral deviation of the cartilagenous nasal septum
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• dysplastic lateral nasal wall development
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• lateral deviation of the cartilagenous nasal septum
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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