All Phenotypes Myo15a<sh2-J> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myo15a^sh2-J
shaker 2 Jackson
MGI:1889795

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Myo15a^sh2-J/Myo15a^tm1.1Jebd	involves: C57BL/6 * C57BLKS * FVB/N	MGI:6192760

Allelic Composition	Myo15a^sh2-J/Myo15a^tm1.1Jebd
Genetic Background	involves: C57BL/6 * C57BLKS * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo15a^sh2-J mutation (1 available); any Myo15a mutation (136 available)
Myo15a^tm1.1Jebd mutation (0 available); any Myo15a mutation (136 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

cochlear hair cell degeneration ( J:226820 )

• stereocilia bundles of inner and outer hair cells degenerate after P4, with degeneration specific to the mechanotransducing shorter row stereocilia and not affecting the tallest rows

increased or absent threshold for auditory brainstem response ( J:226820 )

• in P21 and P70 mice

deafness ( J:226820 )

• profound hearing impairment at P21 and P70

nervous system

cochlear hair cell degeneration ( J:226820 )

• stereocilia bundles of inner and outer hair cells degenerate after P4, with degeneration specific to the mechanotransducing shorter row stereocilia and not affecting the tallest rows

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