About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map7mshi
male sterility and histoincompatibility
MGI:1889849
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map7mshi/Map7mshi B6.CBy-Map7mshi/Csu MGI:5608791
hm2
 		Map7mshi/Map7mshi involves: BALB/cBy MGI:6157533
ht3
 		Map7Gt(ROSABetageo)1Sor/Map7mshi involves: 129S4/SvJaeSor * BALB/cBy * C57BL/6J MGI:5608793


Genotype
MGI:5608791
hm1
Allelic
Composition		 Map7mshi/Map7mshi
Genetic
Background		 B6.CBy-Map7mshi/Csu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map7mshi mutation (1 available); any Map7 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal seminiferous tubule morphology ( J:148349 )
• at 3 months of age the diameter of the seminiferous tubules is shorter than in controls, the lumen of the tubules are absent, and the tubules consist of predominantly Sertoli cells with occasional spermatogonia
• tubulin staining of testes cross sections shows diffuse expression of microtubules with little evidence for organization into bundles, and there is some extracellular vacuolization but to a lesser degree than that of mice homozygous for the Gt(ROSABetageo)1Sor allele
decreased testis weight ( J:148349 )
• homozygotes have much smaller testes, on average less than 75mg where heterozygous controls have an average testes weight of over 200mg
male infertility ( J:148349 )
• although males copulate and cause vaginal plugs, they fail to impregnate females

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:148349 )
• at 3 months of age the diameter of the seminiferous tubules is shorter than in controls, the lumen of the tubules are absent, and the tubules consist of predominantly Sertoli cells with occasional spermatogonia
• tubulin staining of testes cross sections shows diffuse expression of microtubules with little evidence for organization into bundles, and there is some extracellular vacuolization but to a lesser degree than that of mice homozygous for the Gt(ROSABetageo)1Sor allele
decreased testis weight ( J:148349 )
• homozygotes have much smaller testes, on average less than 75mg where heterozygous controls have an average testes weight of over 200mg




Genotype
MGI:6157533
hm2
Allelic
Composition		 Map7mshi/Map7mshi
Genetic
Background		 involves: BALB/cBy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map7mshi mutation (1 available); any Map7 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:37165 )
• the tubules are vacuolated with inadequate tubule lumina development
abnormal seminiferous tubule epithelium morphology ( J:37165 )
• the seminiferous epithelium is disorganized
ectopic Sertoli cells ( J:37165 )
• the Sertoli cells are displaced from their normal position in homozygotes
increased Leydig cell number ( J:37165 )
• leydig cells occupy relatively more of the testes in homozygotes than in age-matched wild-type controls

immune system
decreased length of allograft survival ( J:37165 )
• homozygous mice reject sex-matched skin grafts from congenic BALB/cBy mice unlike wild-type mice

reproductive system
arrest of male meiosis ( J:37165 )
• by 3 weeks a delay in the onset of spermatogenesis is apparent and by 5 weeks greatly reduced numbers of spermatogenic cells are seen in homozygotes
• the spermatogenic cells that are present do not progress past the meiotic spermatocyte stages
abnormal seminiferous tubule morphology ( J:37165 )
• the tubules are vacuolated with inadequate tubule lumina development
abnormal seminiferous tubule epithelium morphology ( J:37165 )
• the seminiferous epithelium is disorganized
ectopic Sertoli cells ( J:37165 )
• the Sertoli cells are displaced from their normal position in homozygotes
increased Leydig cell number ( J:37165 )
• leydig cells occupy relatively more of the testes in homozygotes than in age-matched wild-type controls
male infertility ( J:37165 )
• males are completely sterile

cellular
arrest of male meiosis ( J:37165 )
• by 3 weeks a delay in the onset of spermatogenesis is apparent and by 5 weeks greatly reduced numbers of spermatogenic cells are seen in homozygotes
• the spermatogenic cells that are present do not progress past the meiotic spermatocyte stages




Genotype
MGI:5608793
ht3
Allelic
Composition		 Map7Gt(ROSABetageo)1Sor/Map7mshi
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/cBy * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map7Gt(ROSABetageo)1Sor mutation (1 available); any Map7 mutation (240 available)
Map7mshi mutation (1 available); any Map7 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:148349 )
• at 3 months of age the diameter of the seminiferous tubules is shorter than in controls, the lumen of the tubules are absent, and the tubules consist of predominantly Sertoli cells with occasional spermatogonia
• tubulin staining of testes cross sections shows diffuse expression of microtubules with little evidence for organization into bundles, and there is some extracellular vacuolization but to a lesser degree than that of mice homozygous for the Gt(ROSABetageo)1Sor allele
decreased testis weight ( J:148349 )
• compound heterozygotes have a testes weight decreased to a similar degree as individual homozygotes for each allele, with the average weight less than 75mg compared with a heterozygous weight of 225 mg

reproductive system
abnormal seminiferous tubule morphology ( J:148349 )
• at 3 months of age the diameter of the seminiferous tubules is shorter than in controls, the lumen of the tubules are absent, and the tubules consist of predominantly Sertoli cells with occasional spermatogonia
• tubulin staining of testes cross sections shows diffuse expression of microtubules with little evidence for organization into bundles, and there is some extracellular vacuolization but to a lesser degree than that of mice homozygous for the Gt(ROSABetageo)1Sor allele
decreased testis weight ( J:148349 )
• compound heterozygotes have a testes weight decreased to a similar degree as individual homozygotes for each allele, with the average weight less than 75mg compared with a heterozygous weight of 225 mg

cellular




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory