Phenotypes associated with this allele

• Allele Symbol: Tg(Erbb2)1Jek
• Allele Name: transgene insertion 1, Jeffrey E Kudlow
• Allele ID: MGI:1891491
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Erbb2)1Jek/0	involves: C57BL/6 * SJL	MGI:2174836

Genotype
MGI:2174836

tg1

• Allelic Composition: Tg(Erbb2)1Jek/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:47225 )

• all but two of the founder mice are still born or die within 8 hours of birth; two founders survive to at least 3 weeks of age and one to at least 3 months of age

growth/size/body

postnatal growth retardation ( J:47225 )

• seen in the one surviving female founder mouse at 3 weeks of age

neoplasm

increased papilloma incidence ( J:47225 )

• by 2 months of age, papilloma-like ulcerated lesions are seen, predominantly on the dorsal surface of the tail and the ears, in the male surviving founder mouse

preneoplasia ( J:47225 )

• PCNA immunoreactivity is seen in skin lesions of the one surviving founder mouse at 3 weeks of age, indicating preneoplasia

digestive/alimentary system

esophageal epithelium hyperplasia ( J:47225 )

• seen in the one surviving founder mouse at 3 months of age

vision/eye

eyelid hyperplasia ( J:47225 )

• hyperplastic eyelid in the surviving female founder such that the eyes do not open

integument

abnormal keratinocyte differentiation ( J:47225 )

• marker analysis indicates severe defects in terminal differentiation of keratinocytes in the epidermis

progressive hair loss ( J:47225 )

• progressive hair loss, predominantly on the head and back of the surviving founder mice

decreased hair follicle number ( J:47225 )

• the number of normal hair follicles is decreased and they are replaced with hyperplastic hair follicle-like structures

hyperkeratosis ( J:47225 )

enlarged spinous cells ( J:47225 )

• seen in the founder mice that die in the perinatal period

epidermal hyperplasia ( J:47225 )

• seen in the surviving founders

pallor ( J:47225 )

• skin is pale-looking in the founder mice

scaly skin ( J:47225 )

• seen in 5 founder mice that die in the perinatal period

skin hyperplasia ( J:47225 )

thick skin ( J:47225 )

• progressive thickening of the skin

cellular

abnormal keratinocyte differentiation ( J:47225 )

• marker analysis indicates severe defects in terminal differentiation of keratinocytes in the epidermis