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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fgf7tm1Efu
targeted mutation 1, Elaine Fuchs
MGI:1891569
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fgf7tm1Efu/Fgf7tm1Efu B6.129-Fgf7tm1Efu MGI:4818351
hm2
Fgf7tm1Efu/Fgf7tm1Efu involves: 129S1/Sv * 129X1/SvJ MGI:4818350
hm3
Fgf7tm1Efu/Fgf7tm1Efu involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2175024
cx4
Fgf5tm1Tzi/Fgf5tm1Tzi
Fgf6tm1Thbr/Fgf6tm1Thbr
Fgf7tm1Efu/Fgf7tm1Efu
involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ MGI:3717582


Genotype
MGI:4818351
hm1
Allelic
Composition
Fgf7tm1Efu/Fgf7tm1Efu
Genetic
Background
B6.129-Fgf7tm1Efu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf7tm1Efu mutation (1 available); any Fgf7 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• pentylenetetrazol-treated mice develop major seizures sooner than similarly treated wild-type mice

nervous system
• pentylenetetrazol-treated mice develop major seizures sooner than similarly treated wild-type mice




Genotype
MGI:4818350
hm2
Allelic
Composition
Fgf7tm1Efu/Fgf7tm1Efu
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf7tm1Efu mutation (1 available); any Fgf7 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at symmetric synapses, synaptic vesicles are smaller than in wild-type mice
• fewer vesicles are docked at symmetric synapses compared to in wild-type mice
• at P14, vesicle clustering in GABAergic synapses is decreased in the CA3 compared to in wild-type mice
• CA3 pyramidal neurons cultured for 14 days have fewer GABAergic vesicles associated with dendrites compared to in cultured wild-type neurons
• however, vesicle clustering in glutamatergic synapses is normal
• the frequency of miniature inhibitory postsynaptic currents (mIPSCs) is decreased compared to in wild-type hippocampal cultures
• however, the amplitude of mIPSCs is normal




Genotype
MGI:2175024
hm3
Allelic
Composition
Fgf7tm1Efu/Fgf7tm1Efu
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf7tm1Efu mutation (1 available); any Fgf7 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• epithelium of collecting ducts is low cuboid rather than high cuboid or columnar
• functionally normal
• fewer papillary collecting ducts
• normal from E11.5 to E13.5, after 3-4 rounds of branching
• few ureteric bud branches in the inner medullary region at E16.5
• kidneys are small while body size is normal
• 30% reduction in the number of nephrons but density normal
• few ureteric bud branches in the inner medullary region at E16.5

homeostasis/metabolism
N
• wound healing is normal

reproductive system
N
• testes and seminal vesicles are normal

hematopoietic system
N
• peripheral lymph nodes show no difference in cellularity or T-cell distribution relative to controls
• bone marrow has similar numbers of hematopoietic precursors as in wild-type
• cellularity is reduced compared to wild-type and heterozygous controls with lower absolute numbers of T cells, B cells and dendritic cells

immune system
N
• thymopoeisis and T-cell development are normal in mutants
• cellularity is reduced compared to wild-type and heterozygous controls with lower absolute numbers of T cells, B cells and dendritic cells
• after sublethal irradiation, thymic cellularity and thymic subpopulations are significantly lower than in controls at 21 and 28 days after irradiation indicating defective thymic recovery
• irradiated mice transplanted with allogeneic bone marrow from wild-type mice have decreased numbers of host- and donor-derived T cells compared to wild-type

integument
N
• no major abnormalities in hair structure or hair types
• hair lengths normal
• perturbation in the direction of hairs within the coat
• by 2 months in males
• by 1 year in females
• phenotype becomes more prominent with age
• no excess of oil or greasy substances
• by 2 months in males
• by 1 year in females
• phenotype becomes more prominent with age




Genotype
MGI:3717582
cx4
Allelic
Composition
Fgf5tm1Tzi/Fgf5tm1Tzi
Fgf6tm1Thbr/Fgf6tm1Thbr
Fgf7tm1Efu/Fgf7tm1Efu
Genetic
Background
involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf5tm1Tzi mutation (0 available); any Fgf5 mutation (15 available)
Fgf6tm1Thbr mutation (0 available); any Fgf6 mutation (10 available)
Fgf7tm1Efu mutation (1 available); any Fgf7 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• hair length is increased compared to Fgf5tm1Tzi homozygotes





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory