All Phenotypes Myf6<tm1Eno> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myf6^tm1Eno
targeted mutation 1, Eric N Olson
MGI:1913092

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myf6^tm1Eno/Myf6^tm1Eno	involves: 129S7/SvEvBrd	MGI:2175128
cx2	Myf5^tm1Jae/Myf5⁺ Myf6^tm1Eno/Myf6⁺	involves: 129S4/SvJae * 129S7/SvEvBrd	MGI:3714469
cx3	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1^tm1Jae	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:3714510
cx4	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1⁺ Myog^tm1Whk/Myog⁺	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:3714517
cx5	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1^tm1Jae Myog^tm1Whk/Myog⁺	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:3714518
cx6	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1^tm1Jae Myog^tm1Whk/Myog^tm1Whk	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:3714533
cx7	Myf6^tm1Eno/Myf6^tm1Eno Myog^tm1Whk/Myog^tm1Whk	involves: 129S7/SvEvBrd * C57BL/6	MGI:3714502

Allelic Composition	Myf6^tm1Eno/Myf6^tm1Eno
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf6^tm1Eno mutation (0 available); any Myf6 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal rib morphology ( J:26105 )

• rib anomalies are bilaterally asymmetric and appear to occur randomly in different ribs but show 100% penetrance

• newborns show supernumerary processes in the distal regions of the ribs

abnormal rib development ( J:26105 )

• many ribs appear to emerge from the vertebral bodies at incorrect angles

rib bifurcation ( J:26105 , J:42453 )

• multiple bifurcations (J:26105)

short ribs ( J:42453 )

• distal parts of ribs are missing resulting in short ribs

muscle

muscle phenotype ( J:26105 )

N	• homozygotes exhibit normal distribution of fast- and slow-twitch muscle fibers and normal somite myogenesis

abnormal extraocular muscle morphology ( J:150130 )

• mice have mild extraocular muscle defects compared to Myf5^tm2Tajb homozygotes

abnormal myotome development ( J:42453 )

• myotomes consist of very few myocytes at E10.5 and the myocytes are poorly organized relative to each other, resulting in misshapen and small myotomes

vision/eye

abnormal extraocular muscle morphology ( J:150130 )

• mice have mild extraocular muscle defects compared to Myf5^tm2Tajb homozygotes

Allelic Composition	Myf5^tm1Jae/Myf5⁺ Myf6^tm1Eno/Myf6⁺
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Jae mutation (1 available); any Myf5 mutation (17 available)
Myf6^tm1Eno mutation (0 available); any Myf6 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:42453 )

• 63% of double heterozygous mice, in which the Myf5 and Myf6 alleles are on different chromosomes and show severely reduced expression of Myf5, die immediately after birth; the rest survive

skeleton

abnormal sternocostal joint morphology ( J:42453 )

• attachment failure of at least one rib to the sternum is seen in most mutants, although the identity of the affected rib(s) and the number of ribs affected varies

abnormal rib morphology ( J:42453 )

• abnormal ribs

muscle

abnormal myotome development ( J:42453 )

• number of myocytes in the myotomes is reduced at E10.5 and the conformation of the myotome is abnormal

Allelic Composition	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1^tm1Jae
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf6^tm1Eno mutation (0 available); any Myf6 mutation (19 available)
Myod1^tm1Jae mutation (2 available); any Myod1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:48809 )

• die within minutes after birth due to an inability to breathe

growth/size/body

decreased body size ( J:48809 )

• decrease in body mass at E16.5

muscle

centrally nucleated skeletal muscle fibers ( J:48809 )

• nuclei are centrally located instead of in the periphery as in wild-type

decreased skeletal muscle fiber number ( J:48809 )

• severe skeletal muscle deficiency with only residual muscle fibers surrounded by mononucleated cells

absent skeletal muscle ( J:48809 )

• appear to lack skeletal muscle beginning at E14.5

skeleton

abnormal rib morphology ( J:48809 )

• show rib defects indistinguishable from Myf6^tm1Eno homozygotes

kyphosis ( J:48809 )

• show abnormal curvature of the spine starting around E14.5

adipose tissue

abnormal adipose tissue distribution ( J:48809 )

• accumulate brown fat at the apex of the neck beginning at E14.5

respiratory system

respiratory failure ( J:48809 )

• die within minutes after birth due to an inability to breathe

Allelic Composition	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1⁺ Myog^tm1Whk/Myog⁺
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:48809 )

• mutants are normal, viable and fertile and appear to have normal muscle

Allelic Composition	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1^tm1Jae Myog^tm1Whk/Myog⁺
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal myogenesis ( J:48809 )

• myogenesis is arrested at the level seen in single homozygous Myog mutants

Allelic Composition	Myf6^tm1Eno/Myf6^tm1Eno Myod1^tm1Jae/Myod1^tm1Jae Myog^tm1Whk/Myog^tm1Whk
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:61155 )

• die within minutes of birth

growth/size/body

decreased fetal size ( J:61155 )

• E18.5 mutants show a reduction in body mass

muscle

abnormal muscle development ( J:61155 )

• marker analysis indicates that myoblasts are present in normal muscles but they are unable to differentiate into muscle fibers marker analysis indicates that myoblasts are present in normal muscles but they are unable to differentiate into muscle fibers

• myoblasts from neonates are unable to differentiate in vitro

muscle hypoplasia ( J:61155 )

• severe muscle deficiency with almost no muscle fibers; the few fibers that are present are extremely thin and underdeveloped

• tongue, back, limb, and skeletal muscle are all affected comparably unlike in single Myog homozygous mutants

skeleton

abnormal rib morphology ( J:61155 )

• the average lengths of the ossified portions of the ribs are 30% shorter than normal at E15.5, however the ribs reach the sternum

kyphosis ( J:61155 )

• severe

Allelic Composition	Myf6^tm1Eno/Myf6^tm1Eno Myog^tm1Whk/Myog^tm1Whk
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf6^tm1Eno mutation (0 available); any Myf6 mutation (19 available)
Myog^tm1Whk mutation (0 available); any Myog mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:48809 )

• lethality at birth; mutants exhibit reduced levels of Myf5 mRNA unlike single Myf6^tm1Eno homozygotes

muscle

abnormal muscle fiber morphology ( J:48809 )

• exhibit a deficiency in muscle fibers showing only residual differentiated muscle fibers, however the number of these residual fibers is similar to that seen in Myog homozygotes

muscle hypoplasia ( J:48809 )

• exhibit a deficiency in muscle fibers

skeleton

abnormal sternebra morphology ( J:48809 )

• sternebral bodies are severely malformed

abnormal sternocostal joint morphology ( J:48809 )

• distal portions of the ribs fail to reach the sternum

split sternum ( J:48809 )

• upper region of the sternum is bifurcated

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