All Phenotypes Ndst2<tm1Lkj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ndst2^tm1Lkj
targeted mutation 1, Lena Kjellen
MGI:1913285

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ndst2^tm1Lkj/Ndst2^tm1Lkj	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3806274
cn2	Ndst1^tm1Grob/Ndst1^tm1Grob Ndst2^tm1Lkj/Ndst2^tm1Lkj H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J	MGI:5430386
cn3	Ndst1^tm1Je/Ndst1^tm1Je Ndst2^tm1Lkj/Ndst2^tm1Lkj Tg(Tek-cre)1Ywa/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3589870
cn4	Ndst1^tm1Grob/Ndst1^tm1Grob Ndst2^tm1Lkj/Ndst2^tm1Lkj Tg(Pax6-cre,GFP)1Pgr/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:4943275
cx5	Ndst2^tm1Lkj/Ndst2^tm1Lkj Ndst3^tm1.1Grob/Ndst3^tm1.1Grob	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3806252

Allelic Composition	Ndst2^tm1Lkj/Ndst2^tm1Lkj
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndst2^tm1Lkj mutation (0 available); any Ndst2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mast cell degranulation ( J:57121 )

abnormal mast cell morphology ( J:57121 )

• mast cells contain fewer granules than in wild-type mice

decreased mast cell number ( J:57121 )

• the number of mast cells in the skin is reduced by half compared to in wild-type mice

• mice lack peritoneal mast cells and have few connective tissue mast cells

decreased mast cell histamine storage ( J:57121 )

decreased mast cell protease storage ( J:57121 )

hematopoietic system

decreased mast cell degranulation ( J:57121 )

abnormal mast cell morphology ( J:57121 )

• mast cells contain fewer granules than in wild-type mice

decreased mast cell number ( J:57121 )

• the number of mast cells in the skin is reduced by half compared to in wild-type mice

• mice lack peritoneal mast cells and have few connective tissue mast cells

decreased mast cell histamine storage ( J:57121 )

decreased mast cell protease storage ( J:57121 )

cellular

decreased mast cell degranulation ( J:57121 )

Allelic Composition	Ndst1^tm1Grob/Ndst1^tm1Grob Ndst2^tm1Lkj/Ndst2^tm1Lkj H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Ndst1^tm1Grob mutation (0 available); any Ndst1 mutation (47 available)
Ndst2^tm1Lkj mutation (0 available); any Ndst2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lacrimal gland development ( J:185652 )

• disruption of lacrimal gland budding

absent lacrimal glands ( J:185652 )

endocrine/exocrine glands

abnormal lacrimal gland development ( J:185652 )

• disruption of lacrimal gland budding

absent lacrimal glands ( J:185652 )

Allelic Composition	Ndst1^tm1Je/Ndst1^tm1Je Ndst2^tm1Lkj/Ndst2^tm1Lkj Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndst1^tm1Je mutation (4 available); any Ndst1 mutation (47 available)
Ndst2^tm1Lkj mutation (0 available); any Ndst2 mutation (27 available)
Tg(Tek-cre)1Ywa mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:100456 )

• no pups carrying the cre transgene are born

Allelic Composition	Ndst1^tm1Grob/Ndst1^tm1Grob Ndst2^tm1Lkj/Ndst2^tm1Lkj Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndst1^tm1Grob mutation (0 available); any Ndst1 mutation (47 available)
Ndst2^tm1Lkj mutation (0 available); any Ndst2 mutation (27 available)
Tg(Pax6-cre,GFP)1Pgr mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

absent lacrimal glands ( J:130571 )

• in all mice

vision/eye

absent lacrimal glands ( J:130571 )

• in all mice

Allelic Composition	Ndst2^tm1Lkj/Ndst2^tm1Lkj Ndst3^tm1.1Grob/Ndst3^tm1.1Grob
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndst2^tm1Lkj mutation (0 available); any Ndst2 mutation (27 available)
Ndst3^tm1.1Grob mutation (0 available); any Ndst3 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:138557 )

N	• mice develop normally

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