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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ndst2tm1Rls
targeted mutation 1, Richard L Stevens
MGI:1913286
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ndst2tm1Rls/Ndst2tm1Rls B6.Cg-Ndst2tm1Rls MGI:3828166
hm2
 		Ndst2tm1Rls/Ndst2tm1Rls Not Specified MGI:3806267


Genotype
MGI:3828166
hm1
Allelic
Composition		 Ndst2tm1Rls/Ndst2tm1Rls
Genetic
Background		 B6.Cg-Ndst2tm1Rls
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndst2tm1Rls mutation (0 available); any Ndst2 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell differentiation ( J:142880 )
• synovial mast cells have decreased levels of the proteases mMCP-4, -5, -6, and -7
decreased susceptibility to induced arthritis ( J:142880 )
• there is a 50% decrease in clinical measurements of joint inflammation induced by Tg(TcraR28,TcrbR28)KRNDim (i.e. K/BxN) mouse serum
• ankle thickness is also half that of controls 10 days after arthritis induction
• histological scores of bone and cartilage erosion, as well as inflammation, are also significantly reduced

skeleton
decreased susceptibility to induced arthritis ( J:142880 )
• there is a 50% decrease in clinical measurements of joint inflammation induced by Tg(TcraR28,TcrbR28)KRNDim (i.e. K/BxN) mouse serum
• ankle thickness is also half that of controls 10 days after arthritis induction
• histological scores of bone and cartilage erosion, as well as inflammation, are also significantly reduced

hematopoietic system
abnormal mast cell differentiation ( J:142880 )
• synovial mast cells have decreased levels of the proteases mMCP-4, -5, -6, and -7

cellular
abnormal mast cell differentiation ( J:142880 )
• synovial mast cells have decreased levels of the proteases mMCP-4, -5, -6, and -7




Genotype
MGI:3806267
hm2
Allelic
Composition		 Ndst2tm1Rls/Ndst2tm1Rls
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndst2tm1Rls mutation (0 available); any Ndst2 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased mast cell histamine storage ( J:57120 )
• in mice younger than 4 months histamine exudates from mast cells is decreased to 31% of wild-type
decreased mast cell protease storage ( J:57120 )
• unlike in wild-type mice, mast cells lack metachromatic granules and do not store Cma1 and Cpa3 in their granules
abnormal response to infection ( J:57120 )
• helminth-infected mice exhibit a 50% increase in jejunal mucosa mast cell numbers compared to similarly treated wild-type mice

hematopoietic system
decreased mast cell histamine storage ( J:57120 )
• in mice younger than 4 months histamine exudates from mast cells is decreased to 31% of wild-type
decreased mast cell protease storage ( J:57120 )
• unlike in wild-type mice, mast cells lack metachromatic granules and do not store Cma1 and Cpa3 in their granules

cellular




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory