Analysis Tools
mortality/aging
|
• health deteriorated after weaning, with most dying at a median age of 6 weeks although a small proportion survived for a few months
|
homeostasis/metabolism
dehydration
(
J:47283
)
|
• became dehydrated after weaning
|
behavior/neurological
nervous system
|
• severe with a destruction of the cerebral cortices
|
|
• severe with a destruction of the cerebral cortices
|
|
• the neuropil was frequently distended and torn
|
|
• the hippocampus, thalamus, midbrain, cerebellum, and medualla were generally preserved, although they were compressed
|
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• developed within the first few days of life
|
|
• the ependymal lining of the lateral ventricles was disrupted at multiple sites
|
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• became progressively dilated and were filled with bloody cerebrospinal fluid
|
|
• contained abundant electron lucent cells and an irregular and disorganized microvillus border
|
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• moderately dilated while the fourth ventricle appeared normal
|
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• much of the cerebral cortex was destroyed except for a thin rim composed of neural tissue and meningeal membranes
• necrosis accompanied the cortical atrophy
|
craniofacial
|
• exhibited enlarged, domed craniae by 3-4 weeks of age
|
|
• expanded calvarium
|
skeleton
|
• exhibited enlarged, domed craniae by 3-4 weeks of age
|
|
• expanded calvarium
|
cardiovascular system
|
• severe with a destruction of the cerebral cortices
|
|
• severe with a destruction of the cerebral cortices
|
integument
ruffled hair
(
J:47283
)
|
• developed ruffled coats after weaning
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hydrocephalus | DOID:10908 |
OMIM:123155 OMIM:236600 OMIM:236635 OMIM:307000 OMIM:615219 |
J:47283 | |
