immune system
• cortex of the thymus is underdeveloped
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• thymus cellularity is reduced 10- to a 100- fold compared to controls
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• cell cycling is less robust than controls in thymocytes progressing from the double-negative stage through the intermediate single-positive stage
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• absolute numbers of double-positive thymocytes are reduced 100-fold compared to controls
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• T cell numbers in the lymph node and spleen are reduced 10-fold and 3-fold, respectively
• ratios of the T cell subsets are unaffected
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• decreased CD8+ effector T in the peripheral blood lymphocytes and spleen compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin
• decreased CD8+ memory precursors and memory T cells compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin
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• absolute numbers of single-positive thymocytes are reduced 100-fold compared to controls
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• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice
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skeleton
• low bone density at 1 month of age
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neoplasm
• polyp-like intestinal neoplasms
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• adenoacanthomas
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hematopoietic system
• cortex of the thymus is underdeveloped
|
• thymus cellularity is reduced 10- to a 100- fold compared to controls
|
• cell cycling is less robust than controls in thymocytes progressing from the double-negative stage through the intermediate single-positive stage
|
• T cell numbers in the lymph node and spleen are reduced 10-fold and 3-fold, respectively
• ratios of the T cell subsets are unaffected
|
• absolute numbers of double-positive thymocytes are reduced 100-fold compared to controls
|
• decreased CD8+ effector T in the peripheral blood lymphocytes and spleen compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin
• decreased CD8+ memory precursors and memory T cells compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin
|
• absolute numbers of single-positive thymocytes are reduced 100-fold compared to controls
|
• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice
|
endocrine/exocrine glands
• cortex of the thymus is underdeveloped
|
• thymus cellularity is reduced 10- to a 100- fold compared to controls
|
• adenoacanthomas
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integument
• adenoacanthomas
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digestive/alimentary system
• polyp-like intestinal neoplasms
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