neoplasm
• tumors develop in all mice at 3 to 6 months of age
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• most tumors (>90%) are T cell lymphomas
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cellular
• MEFs are more resistant to UV-induced apoptosis than wild-type MEFs
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• MEFs are more sensitive to etoposide, adriamycin, or cisplatin induced apoptosis than wild-type MEFs
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• several cell types, including lens epithelial cells, show enhanced proliferation (doubling potential) in culture compared to wild-type cells
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endocrine/exocrine glands
• most tumors (>90%) are T cell lymphomas
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hematopoietic system
• most tumors (>90%) are T cell lymphomas
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immune system
• most tumors (>90%) are T cell lymphomas
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