All Phenotypes Trp53<tm1Sia> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trp53^tm1Sia
targeted mutation 1, Shinichi Aizawa
MGI:1926340

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm1Sia/Trp53^tm1Sia	involves: C57BL/6 * CBA	MGI:2174781
hm2	Trp53^tm1Sia/Trp53^tm1Sia	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:7488002
cn3	Ryr2^{tm1(CAG-KRASG12V,-lacZ)Nobs}/Ryr2^{tm1(CAG-KRASG12V,-lacZ)Nobs} Trp53^tm1Sia/Trp53^tm1Sia	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3698871
cx4	Irf1^tm1Mak/Irf1^tm1Mak Trp53^tm1Sia/Trp53^tm1Sia	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:4819238
cx5	Eloa^tm1Aso/Eloa^tm1Aso Trp53^tm1Sia/Trp53^tm1Sia	involves: 129S/SvEv * C57BL/6 * CBA	MGI:3704887
cx6	Ryr2^{tm1(CAG-KRASG12V,-lacZ)Nobs}/Ryr2^{tm1(CAG-KRASG12V,-lacZ)Nobs} Trp53^tm1Sia/Trp53⁺	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3698873
cx7	Puf60^tm1.1Kmtsu/Puf60⁺ Trp53^tm1Sia/Trp53^tm1Sia	involves: C57BL/6NCrlj * C57BL/6NCrSlc * CBA/JNCrlj	MGI:7488004
cx8	Ppp1r13b^tm1Suda/Ppp1r13b^tm1Suda Trp53^tm1Sia/Trp53^tm1Sia	involves: various	MGI:3801105

Allelic Composition	Trp53^tm1Sia/Trp53^tm1Sia
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1Sia mutation (10 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:36762 )

• tumors develop in all mice at 3 to 6 months of age

increased T cell derived lymphoma incidence ( J:36762 )

• most tumors (>90%) are T cell lymphomas

cellular

decreased cellular sensitivity to ultraviolet irradiation ( J:85569 )

• MEFs are more resistant to UV-induced apoptosis than wild-type MEFs

increased sensitivity to induced cell death ( J:85569 )

• MEFs are more sensitive to etoposide, adriamycin, or cisplatin induced apoptosis than wild-type MEFs

abnormal cell proliferation ( J:36762 )

• several cell types, including lens epithelial cells, show enhanced proliferation (doubling potential) in culture compared to wild-type cells

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:36762 )

• most tumors (>90%) are T cell lymphomas

hematopoietic system

increased T cell derived lymphoma incidence ( J:36762 )

• most tumors (>90%) are T cell lymphomas

immune system

increased T cell derived lymphoma incidence ( J:36762 )

• most tumors (>90%) are T cell lymphomas

Allelic Composition	Trp53^tm1Sia/Trp53^tm1Sia
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1Sia mutation (10 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:233347 )

neoplasm

increased T cell derived lymphoma incidence ( J:233347 )

hematopoietic system

increased thymus weight ( J:233347 )

increased T cell derived lymphoma incidence ( J:233347 )

increased spleen weight ( J:233347 )

thrombocytopenia ( J:233347 )

increased leukocyte cell number ( J:233347 )

growth/size/body

increased spleen weight ( J:233347 )

endocrine/exocrine glands

increased thymus weight ( J:233347 )

increased T cell derived lymphoma incidence ( J:233347 )

immune system

increased thymus weight ( J:233347 )

increased T cell derived lymphoma incidence ( J:233347 )

increased spleen weight ( J:233347 )

increased leukocyte cell number ( J:233347 )

Allelic Composition	Ryr2^{tm1(CAG-KRASG12V,-lacZ)Nobs}/Ryr2^{tm1(CAG-KRASG12V,-lacZ)Nobs} Trp53^tm1Sia/Trp53^tm1Sia
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2^{tm1(CAG-KRAS*G12V,-lacZ)Nobs} mutation (1 available); any Ryr2 mutation (325 available)
Trp53^tm1Sia mutation (10 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:117828 )

• within 10 weeks of electroporation of a cre expression vector into the muscles of the lower right leg, soft tissue tumors of the lower right leg develop in 100% of mice, while uninjected mice or injected Ryr2 homozygous, Trp53-sufficient mice (~wild-type) do not develop tumors even after 15 weeks

increased rhabdomyosarcoma incidence ( J:117828 )

• tumors are of this type

immune system

myositis ( J:117828 )

• 3 weeks after electroporation, mice show persistent accumulation of mononuclear cells and contain immature myocytes and proliferating cells, at site of electroporation, whereas controls do not

muscle

myositis ( J:117828 )

• 3 weeks after electroporation, mice show persistent accumulation of mononuclear cells and contain immature myocytes and proliferating cells, at site of electroporation, whereas controls do not

increased rhabdomyosarcoma incidence ( J:117828 )

• tumors are of this type

Allelic Composition	Irf1^tm1Mak/Irf1^tm1Mak Trp53^tm1Sia/Trp53^tm1Sia
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf1^tm1Mak mutation (1 available); any Irf1 mutation (21 available)
Trp53^tm1Sia mutation (10 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:55418 )

• earlier tumor induced death

neoplasm

increased tumor incidence ( J:55418 )

• 96% develop tumors by 299 days of age compared to 56% of mice only homozygous for Trp53^tm1Sia

• greater frequency of multiple tumors

increased lymphoma incidence ( J:55418 )

increased hemangiosarcoma incidence ( J:55418 )

• angiosarcoma

increased teratoma incidence ( J:55418 )

• immature teratomas

Allelic Composition	Eloa^tm1Aso/Eloa^tm1Aso Trp53^tm1Sia/Trp53^tm1Sia
Genetic Background	involves: 129S/SvEv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eloa^tm1Aso mutation (0 available); any Eloa mutation (22 available)
Trp53^tm1Sia mutation (10 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:119126 )

• died at between 10.5 and 12.5 of gestation

• similar to phenotype found in Tceb3^tm1Aso homozygous embryos

embryo

increased embryonic tissue cell apoptosis ( J:119126 )

• in live E10.5 embryos

• similar to phenotype found in Tceb3^tm1Aso homozygous embryos

embryonic growth retardation ( J:119126 )

• in live E10.5 embryos

• morphologically not distinguishable from Tceb3^tm1Aso homozygous embryos

growth/size/body

embryonic growth retardation ( J:119126 )

• in live E10.5 embryos

• morphologically not distinguishable from Tceb3^tm1Aso homozygous embryos

cellular

increased embryonic tissue cell apoptosis ( J:119126 )

• in live E10.5 embryos

• similar to phenotype found in Tceb3^tm1Aso homozygous embryos

Allelic Composition	Ryr2^{tm1(CAG-KRASG12V,-lacZ)Nobs}/Ryr2^{tm1(CAG-KRASG12V,-lacZ)Nobs} Trp53^tm1Sia/Trp53⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:117828 )

• within 10 weeks of electroporation of a cre expression vector into the muscles of the lower right leg, soft tissue tumors of the lower right leg develop in 40% of mice

increased rhabdomyosarcoma incidence ( J:117828 )

• tumors are of this type

muscle

increased rhabdomyosarcoma incidence ( J:117828 )

• tumors are of this type

Allelic Composition	Puf60^tm1.1Kmtsu/Puf60⁺ Trp53^tm1Sia/Trp53^tm1Sia
Genetic Background	involves: C57BL/6NCrlj * C57BL/6NCrSlc * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Puf60^tm1.1Kmtsu mutation (0 available); any Puf60 mutation (32 available)
Trp53^tm1Sia mutation (10 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:233347 )

N	• unlike Trp53^tm1Sia homozygotes

reproductive system

reduced fertility ( J:233347 )

neoplasm

increased T cell derived lymphoma incidence ( J:233347 )

• atypical cells in the peripheral blood, bone marrow, liver, spleen, and thymus with larger cells than in Trp53^tm1Sia homozygotes

increased metastatic potential ( J:233347 )

• increased bone marrow invasion compared with Trp53^tm1Sia homozygotes

hematopoietic system

increased thymus weight ( J:233347 )

• more so than in Trp53^tm1Sia homozygotes

increased T cell derived lymphoma incidence ( J:233347 )

• atypical cells in the peripheral blood, bone marrow, liver, spleen, and thymus with larger cells than in Trp53^tm1Sia homozygotes

increased spleen weight ( J:233347 )

• more so than in Trp53^tm1Sia homozygotes

decreased erythrocyte cell number ( J:233347 )

thrombocytopenia ( J:233347 )

• more so than in Trp53^tm1Sia homozygotes

increased leukocyte cell number ( J:233347 )

growth/size/body

decreased body weight ( J:233347 )

• at time of sacrifice

increased spleen weight ( J:233347 )

• more so than in Trp53^tm1Sia homozygotes

endocrine/exocrine glands

increased thymus weight ( J:233347 )

• more so than in Trp53^tm1Sia homozygotes

increased T cell derived lymphoma incidence ( J:233347 )

• atypical cells in the peripheral blood, bone marrow, liver, spleen, and thymus with larger cells than in Trp53^tm1Sia homozygotes

respiratory system

respiratory distress ( J:233347 )

• with a loss of movement at time of sacrifice

immune system

increased thymus weight ( J:233347 )

• more so than in Trp53^tm1Sia homozygotes

increased T cell derived lymphoma incidence ( J:233347 )

• atypical cells in the peripheral blood, bone marrow, liver, spleen, and thymus with larger cells than in Trp53^tm1Sia homozygotes

increased spleen weight ( J:233347 )

• more so than in Trp53^tm1Sia homozygotes

increased leukocyte cell number ( J:233347 )

Allelic Composition	Ppp1r13b^tm1Suda/Ppp1r13b^tm1Suda Trp53^tm1Sia/Trp53^tm1Sia
Genetic Background	involves: various

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r13b^tm1Suda mutation (0 available); any Ppp1r13b mutation (53 available)
Trp53^tm1Sia mutation (10 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal lymphatic vessel morphology ( J:135686 )

• collecting lymphatic vessels along both side of the ischiatic vein were missing and appeared tortuous, distended, or fused to form single vessels in adult homozygous mice

• this phenotype is not enhanced or suppressed by presence of Trp53^tm1Sia mutation as compared to Ppp1r13b^tm1Suda homozygous mice

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