All Phenotypes Foxn1<tm1Tbo> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxn1^tm1Tbo/Foxn1^tm1Tbo	involves: 129S1/Sv	MGI:2175031
ht2	Foxn1^tm1.1Cbln/Foxn1^tm1Tbo	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:5297815
ht3	Foxn1^nu-StL/Foxn1^tm1Tbo	involves: 129S1/Sv * C57BL/6	MGI:3722653
cn4	Foxn1^tm1.1Cbln/Foxn1^tm1Tbo Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:5297816

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal thymus morphology ( J:33796 )

abnormal thymus development ( J:33796 )

• thymic rudiment in the mediastinum above the heart

abnormal thymus epithelium morphology ( J:177992 )

• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked

• cortical epithelial primordia do not develop

athymia ( J:33796 )

abnormal leukocyte cell number ( J:33796 )

increased B cell number ( J:33796 )

• 2 fold increase in splenic B cells but meseteric lymph node frequency remains unchanged

absent T cells ( J:33796 )

• complete absence of alpha/beta T-cells

hematopoietic system

abnormal thymus morphology ( J:33796 )

abnormal thymus development ( J:33796 )

• thymic rudiment in the mediastinum above the heart

abnormal thymus epithelium morphology ( J:177992 )

• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked

• cortical epithelial primordia do not develop

athymia ( J:33796 )

abnormal leukocyte cell number ( J:33796 )

increased B cell number ( J:33796 )

• 2 fold increase in splenic B cells but meseteric lymph node frequency remains unchanged

absent T cells ( J:33796 )

• complete absence of alpha/beta T-cells

integument

hairless ( J:33796 )

abnormal hair follicle development ( J:61394 )

• loss of expression of some but not all hair keratin genes

endocrine/exocrine glands

abnormal thymus morphology ( J:33796 )

abnormal thymus development ( J:33796 )

• thymic rudiment in the mediastinum above the heart

abnormal thymus epithelium morphology ( J:177992 )

• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked

• cortical epithelial primordia do not develop

athymia ( J:33796 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
T-cell immunodeficiency, congenital alopecia, and nail dystrophy		DOID:0060769	OMIM:601705	J:33796

Allelic Composition	Foxn1^tm1.1Cbln/Foxn1^tm1Tbo
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

small thymus ( J:177992 )

• small alymphatic thymic rudiments

• devoid of cortical or medullary organization

• no hematopoietic colonization of the thymus

absent T cells ( J:177992 )

• lack peripheral T cells

hematopoietic system

small thymus ( J:177992 )

• small alymphatic thymic rudiments

• devoid of cortical or medullary organization

• no hematopoietic colonization of the thymus

absent T cells ( J:177992 )

• lack peripheral T cells

integument

abnormal hair growth ( J:177992 )

• sporadic hair loss after 6 weeks of age

• overtly normal hair up to 6 weeks of age

endocrine/exocrine glands

small thymus ( J:177992 )

• small alymphatic thymic rudiments

• devoid of cortical or medullary organization

• no hematopoietic colonization of the thymus

Allelic Composition	Foxn1^nu-StL/Foxn1^tm1Tbo
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1^nu-StL mutation (0 available); any Foxn1 mutation (106 available)
Foxn1^tm1Tbo mutation (0 available); any Foxn1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal thymus development ( J:63313 )

• thymic rudiment is composed of a patch of epithelial cells lining cysts with a complete absence of hematopoietic cells

athymia ( J:63313 )

hematopoietic system

abnormal thymus development ( J:63313 )

• thymic rudiment is composed of a patch of epithelial cells lining cysts with a complete absence of hematopoietic cells

athymia ( J:63313 )

endocrine/exocrine glands

abnormal thymus development ( J:63313 )

• thymic rudiment is composed of a patch of epithelial cells lining cysts with a complete absence of hematopoietic cells

athymia ( J:63313 )

Allelic Composition	Foxn1^tm1.1Cbln/Foxn1^tm1Tbo Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1^tm1.1Cbln mutation (0 available); any Foxn1 mutation (106 available)
Foxn1^tm1Tbo mutation (0 available); any Foxn1 mutation (106 available)
Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn} mutation (1 available); any Gt(ROSA)26Sor mutation (958 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:177992 )

N	• restoration of normal thymus if cre induction with tamoxiphen occurs before 4 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/12/2024 MGI 6.13