All Phenotypes Foxn1<tm1Tbo> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxn1^tm1Tbo/Foxn1^tm1Tbo	involves: 129S1/Sv	MGI:2175031
ht2	Foxn1^tm1.1Cbln/Foxn1^tm1Tbo	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:5297815
ht3	Foxn1^nu-StL/Foxn1^tm1Tbo	involves: 129S1/Sv * C57BL/6	MGI:3722653
cn4	Foxn1^tm1.1Cbln/Foxn1^tm1Tbo Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:5297816

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal thymus morphology ( J:33796 )

abnormal thymus development ( J:33796 )

• thymic rudiment in the mediastinum above the heart

abnormal thymus epithelium morphology ( J:177992 )

• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked

• cortical epithelial primordia do not develop

athymia ( J:33796 )

abnormal leukocyte cell number ( J:33796 )

increased B cell number ( J:33796 )

• 2 fold increase in splenic B cells but meseteric lymph node frequency remains unchanged

absent T cells ( J:33796 )

• complete absence of alpha/beta T-cells

hematopoietic system

abnormal thymus morphology ( J:33796 )

abnormal thymus development ( J:33796 )

• thymic rudiment in the mediastinum above the heart

abnormal thymus epithelium morphology ( J:177992 )

• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked

• cortical epithelial primordia do not develop

athymia ( J:33796 )

abnormal leukocyte cell number ( J:33796 )

increased B cell number ( J:33796 )

• 2 fold increase in splenic B cells but meseteric lymph node frequency remains unchanged

absent T cells ( J:33796 )

• complete absence of alpha/beta T-cells

integument

hairless ( J:33796 )

abnormal hair follicle development ( J:61394 )

• loss of expression of some but not all hair keratin genes

endocrine/exocrine glands

abnormal thymus morphology ( J:33796 )

abnormal thymus development ( J:33796 )

• thymic rudiment in the mediastinum above the heart

abnormal thymus epithelium morphology ( J:177992 )

• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked

• cortical epithelial primordia do not develop

athymia ( J:33796 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
T-cell immunodeficiency, congenital alopecia, and nail dystrophy		DOID:0060769	OMIM:601705	J:33796

Allelic Composition	Foxn1^tm1.1Cbln/Foxn1^tm1Tbo
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

small thymus ( J:177992 )

• small alymphatic thymic rudiments

• devoid of cortical or medullary organization

• no hematopoietic colonization of the thymus

absent T cells ( J:177992 )

• lack peripheral T cells

hematopoietic system

small thymus ( J:177992 )

• small alymphatic thymic rudiments

• devoid of cortical or medullary organization

• no hematopoietic colonization of the thymus

absent T cells ( J:177992 )

• lack peripheral T cells

integument

abnormal hair growth ( J:177992 )

• sporadic hair loss after 6 weeks of age

• overtly normal hair up to 6 weeks of age

endocrine/exocrine glands

small thymus ( J:177992 )

• small alymphatic thymic rudiments

• devoid of cortical or medullary organization

• no hematopoietic colonization of the thymus

Allelic Composition	Foxn1^nu-StL/Foxn1^tm1Tbo
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1^nu-StL mutation (0 available); any Foxn1 mutation (106 available)
Foxn1^tm1Tbo mutation (0 available); any Foxn1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal thymus development ( J:63313 )

• thymic rudiment is composed of a patch of epithelial cells lining cysts with a complete absence of hematopoietic cells

athymia ( J:63313 )

hematopoietic system

abnormal thymus development ( J:63313 )

• thymic rudiment is composed of a patch of epithelial cells lining cysts with a complete absence of hematopoietic cells

athymia ( J:63313 )

endocrine/exocrine glands

abnormal thymus development ( J:63313 )

• thymic rudiment is composed of a patch of epithelial cells lining cysts with a complete absence of hematopoietic cells

athymia ( J:63313 )

Allelic Composition	Foxn1^tm1.1Cbln/Foxn1^tm1Tbo Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1^tm1.1Cbln mutation (0 available); any Foxn1 mutation (106 available)
Foxn1^tm1Tbo mutation (0 available); any Foxn1 mutation (106 available)
Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:177992 )

N	• restoration of normal thymus if cre induction with tamoxiphen occurs before 4 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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