Phenotypes associated with this allele

• Allele Symbol: Tg(IGF1)1Jdg
• Allele Name: transgene insertion 1, John DiGiovanni
• Allele ID: MGI:1926378
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(IGF1)1Jdg/0	involves: FVB * ICR	MGI:2174852

Genotype
MGI:2174852

tg1

• Allelic Composition: Tg(IGF1)1Jdg/0
• Genetic Background: involves: FVB * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:39752 )

• mutants exposed to an initiation-promotion protocol using DMBA-TPA develop tumors faster and in greater numbers than similarly treated controls

increased skin papilloma incidence ( J:39752 )

• 60% of mutants treated with the tumor promoter, TPA develop skin papillomas by 20 weeks of promotion compared to no tumors in controls

hearing/vestibular/ear

big ears ( J:39752 )

early ear unfolding ( J:39752 )

• at birth

excessive ear growth ( J:39752 )

• at birth

craniofacial

big ears ( J:39752 )

early ear unfolding ( J:39752 )

• at birth

excessive ear growth ( J:39752 )

• at birth

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:39752 )

• mutants exposed to an initiation-promotion protocol using DMBA-TPA develop tumors faster and in greater numbers than similarly treated controls

integument

abnormal hair shaft morphology ( J:39752 )

• hair shafts are elongated

thick hypodermis ( J:39752 )

premature hair follicle generation ( J:39752 )

• hair emerges about 2 days earlier than in controls

thick dermal layer ( J:39752 )

hyperkeratosis ( J:39752 )

epidermal hyperplasia ( J:39752 )

wrinkled skin ( J:39752 )

• by 2-3 days of age, the skin is more wrinkled than that of controls

thick skin ( J:39752 )

• by 2-3 days of age, the skin is thicker

increased skin papilloma incidence ( J:39752 )

• 60% of mutants treated with the tumor promoter, TPA develop skin papillomas by 20 weeks of promotion compared to no tumors in controls

growth/size/body

big ears ( J:39752 )

early ear unfolding ( J:39752 )

• at birth

excessive ear growth ( J:39752 )

• at birth