Phenotypes associated with this allele

• Allele Symbol: Tg(APOC1)3Lmh
• Allele Name: transgene insertion 3, Louis M Havekes
• Allele ID: MGI:1926380
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(APOC1)1Lmh/0 Tg(APOC1)3Lmh/0	C57BL/6-Tg(APOC1)1Lmh Tg(APOC1)3Lmh	MGI:3764676
tg2	Tg(APOC1)3Lmh/Y	C57BL/6-Tg(APOC1)3Lmh	MGI:2174817
tg3	Tg(APOC1)3Lmh/0	C57BL/6-Tg(APOC1)3Lmh	MGI:3764671
tg4	Tg(APOC1)3Lmh/?	C57BL/6-Tg(APOC1)3Lmh	MGI:3764682

Genotype
MGI:3764676

cx1

• Allelic Composition: Tg(APOC1)1Lmh/0; Tg(APOC1)3Lmh/0
• Genetic Background: C57BL/6-Tg(APOC1)1Lmh Tg(APOC1)3Lmh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:65036 )

increased circulating free fatty acids level ( J:65036 )

increased circulating triglyceride level ( J:65036 )

vision/eye

abnormal eye morphology ( J:65036 )

• develop extensive crusts around the eyes

integument

sebaceous gland atrophy ( J:65036 )

alopecia ( J:65036 )

• hair loss becomes more severe upon aging, such that older mutants appear almost hairless

dry skin ( J:65036 )

scaly skin ( J:65036 )

• fine epidermal scaling

thick skin ( J:65036 )

increased pruritus ( J:65036 )

• develop pruritus

endocrine/exocrine glands

sebaceous gland atrophy ( J:65036 )

Genotype
MGI:2174817

tg2

• Allelic Composition: Tg(APOC1)3Lmh/Y
• Genetic Background: C57BL/6-Tg(APOC1)3Lmh

homeostasis/metabolism

increased circulating cholesterol level ( J:65036 )

♂

increased circulating VLDL cholesterol level ( J:65036 )

♂ • increases in cholesterol are mainly due to elevated VLDL levels

increased circulating free fatty acids level ( J:65036 )

♂

increased circulating triglyceride level ( J:65036 )

♂

increased circulating VLDL triglyceride level ( J:65036 )

♂ • increases in triglycerides are mainly due to elevated VLDL levels

vision/eye

abnormal eye morphology ( J:65036 )

♂ • develop extensive crusts around the eyes

integument

sebaceous gland atrophy ( J:65036 )

♂

alopecia ( J:65036 )

♂ • hair loss becomes more severe upon aging, such that older mutants appear almost hairless

dry skin ( J:65036 )

♂

scaly skin ( J:65036 )

♂ • fine epidermal scaling

thick skin ( J:65036 )

♂

increased pruritus ( J:65036 )

♂ • develop pruritus

endocrine/exocrine glands

sebaceous gland atrophy ( J:65036 )

♂

Genotype
MGI:3764671

tg3

• Allelic Composition: Tg(APOC1)3Lmh/0
• Genetic Background: C57BL/6-Tg(APOC1)3Lmh

homeostasis/metabolism

increased circulating cholesterol level ( J:65036 )

• slightly elevated levels of serum cholesterol

increased circulating free fatty acids level ( J:65036 )

increased circulating triglyceride level ( J:65036 )

• slightly elevated levels of triglycerides

Genotype
MGI:3764682

tg4

• Allelic Composition: Tg(APOC1)3Lmh/?
• Genetic Background: C57BL/6-Tg(APOC1)3Lmh

homeostasis/metabolism

increased circulating cholesterol level ( J:65146 )

• serum cholesterol levels are slightly increased when fed a high fat diet, however cholesterol and triglyceride levels are normal on a regular or sucrose-rich diet