Analysis Tools
mortality/aging
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• most homozygotes die between P7 and P14; only about 10% survive to adulthood
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growth/size/body
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• as early as P6, homozygotes display abnormally rounded, brittle filiform papillae that shatter during usage; broken pieces of filiform papillae are often found on the tongue surface
• in contrast, fungiform papillae appear normal and the overall shape of the tongue is unaffected
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weight loss
(
J:45400
)
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• newborn homozygotes exhibit progressive weight loss relative to wild-type littermates
• however, homozygotes that survive >2 weeks are fertile, healthy, and slowly approach the weight of wild-type siblings after weaning
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digestive/alimentary system
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• as early as P6, homozygotes display abnormally rounded, brittle filiform papillae that shatter during usage; broken pieces of filiform papillae are often found on the tongue surface
• in contrast, fungiform papillae appear normal and the overall shape of the tongue is unaffected
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skeleton
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• adult homozygotes have no appendicular skeleton defects but show an increased number of caudal vertebrae with lateral processes
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• adult homozygotes display 10-13 caudal vertebrae with lateral processes whereas wild-type mice have only 4-5; however, no increase in the total number of caudal vertebrae is observed, suggesting a true homeotic transformation
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limbs/digits/tail
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• adult homozygotes display 10-13 caudal vertebrae with lateral processes whereas wild-type mice have only 4-5; however, no increase in the total number of caudal vertebrae is observed, suggesting a true homeotic transformation
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hairless tail
(
J:45400
)
|
• adult homozygotes lack tail hairs; however, tail scales appear grossly unaffected
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behavior/neurological
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• newborn homozygotes exhibit progressive weakness relative to wild-type littermates
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vision/eye
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• adult homozygotes show absence of cilia (eyelashes)
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craniofacial
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• as early as P6, homozygotes display abnormally rounded, brittle filiform papillae that shatter during usage; broken pieces of filiform papillae are often found on the tongue surface
• in contrast, fungiform papillae appear normal and the overall shape of the tongue is unaffected
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integument
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• in rare cases, hair can be found protruding from the epidermis in protected regions (e.g. along the lower limbs)
• occasionally, in-grown hairs are observed within the epidermis
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• adult homozygotes exhibit an absence of all pelage (or coat) hair types as well as tail and peri-anal hairs; all hair types are apparently affected
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• adult homozygotes show absence of cilia (eyelashes)
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brittle hair
(
J:45400
)
|
• adult homozygotes have brittle hair; pelage hair forms but is fractured at the skin surface resulting in alopecia
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• adult homozygotes display misshapen, flatter nails instead of normal talon-shaped nails
• mutant nails are often overgrown forming long spirals
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• newborn homozygotes lack vibrissae at birth
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