Phenotypes associated with this allele

• Allele Symbol: Gab1^tm1Thir
• Allele Name: targeted mutation 1, Toshio Hirano
• Allele ID: MGI:1926435
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gab1^tm1Thir/Gab1^tm1Thir	involves: C57BL/6	MGI:2175036

Genotype
MGI:2175036

hm1

• Allelic Composition: Gab1^tm1Thir/Gab1^tm1Thir
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:61790 )

• the proportion of viable homozygous mutant mice declines from E12.5 to E17.5, with none born alive

cardiovascular system

ventricular hypoplasia ( J:61790 )

dilated heart left ventricle ( J:61790 )

thin ventricular wall ( J:61790 )

• homozygotes surviving beyond E13.5 display an extremely thin ventricular wall

dilated heart right ventricle ( J:61790 )

hemorrhage ( J:61790 )

• after E13.5, some homozygotes exhibit hemorrhage

hemopericardium ( J:61790 )

• at E10.5-E11.5, ~40% of homozygotes contain blood in the pericardial cavity

embryo

decreased embryo size ( J:61790 )

• after E13.5, homozygotes are smaller than wild-type embryos

decreased trophoblast giant cell number ( J:61790 )

placental labyrinth hypoplasia ( J:61790 )

• after E13.5, homozygotes display a hypoplastic labyrinth region

small placenta ( J:61790 )

• after E13.5, mutant placentas are pale and smaller than wild-type placentas

vision/eye

early eyelid opening ( J:61790 )

• homozygotes surviving beyond E16.5 have open eyes

absent eyelids ( J:61790 )

• homozygotes surviving beyond E16.5 have no eyelids

growth/size/body

decreased embryo size ( J:61790 )

• after E13.5, homozygotes are smaller than wild-type embryos

homeostasis/metabolism

hemopericardium ( J:61790 )

• at E10.5-E11.5, ~40% of homozygotes contain blood in the pericardial cavity

integument

abnormal hair follicle development ( J:61790 )

• after E13.5, homozygotes display underdeveloped hair follicles

abnormal epidermis stratum granulosum morphology ( J:61790 )

• after E13.5, the mutant stratum granulosum is thinner whereas the basal layer remains unchanged

thin epidermis ( J:61790 )

petechiae ( J:61790 )

• after E13.5, some homozygotes exhibit petechiae