All Phenotypes Itgb6<tm1Des> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Itgb6^tm1Des
targeted mutation 1, Dean Sheppard
MGI:1926484

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgb6^tm1Des/Itgb6^tm1Des	either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)	MGI:3770663
hm2	Itgb6^tm1Des/Itgb6^tm1Des	involves: 129S4/SvJae	MGI:3717771
hm3	Itgb6^tm1Des/Itgb6^tm1Des	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3832435
hm4	Itgb6^tm1Des/Itgb6^tm1Des	involves: 129S4/SvJae * C57BL/6J	MGI:2175082
hm5	Itgb6^tm1Des/Itgb6^tm1Des	involves: 129T2/SvEms	MGI:3581437
cx6	Itgb6^tm1Des/Itgb6^tm1Des Mmp12^tm1Sds/Mmp12^tm1Sds	involves: 129/Sv * 129T2/SvEms	MGI:3581438
cx7	Itgb6^tm1Des/Itgb6^tm1Des Tg(SFTPC-ITGB6)1Des/?	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3832436

Allelic Composition	Itgb6^tm1Des/Itgb6^tm1Des
Genetic Background	either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6^tm1Des mutation (0 available); any Itgb6 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:109367 )

• treatment with angiotensin II and aldosterone reduces macrophage invasion where as it increases macrophage invasion in wild-type mice

decreased susceptibility to injury ( J:109367 )

• tubulointerstitial damage and fibrosis induction are less than in wild-type mice following kidney obstruction

Allelic Composition	Itgb6^tm1Des/Itgb6^tm1Des
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6^tm1Des mutation (0 available); any Itgb6 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Abnormal vascular development in Tgfb1^tm1Jmu/Tgfb1^tm1Jmu mice and fewer Langerhans cells in Tgfb1^tm1Jmu/Tgfb1^tm1Jmu and Itgb6^tm1Des/Itgb6^tm1Des mice

immune system

decreased Langerhans cell number ( J:120085 )

• Langerhans cells are less abundant in back epidermis

absent Langerhans cell ( J:120085 )

• Langerhans cells are absent from ear epidermis

abnormal immune system physiology ( J:120085 )

• mild inflammation occurs in the lung and skin

hematopoietic system

decreased Langerhans cell number ( J:120085 )

• Langerhans cells are less abundant in back epidermis

absent Langerhans cell ( J:120085 )

• Langerhans cells are absent from ear epidermis

Allelic Composition	Itgb6^tm1Des/Itgb6^tm1Des
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6^tm1Des mutation (0 available); any Itgb6 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

respiratory system inflammation ( J:51592 )

• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles

• increased numbers of eosinophiles recovered by bronchoalveolar lavage

immune system

respiratory system inflammation ( J:51592 )

• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles

• increased numbers of eosinophiles recovered by bronchoalveolar lavage

Allelic Composition	Itgb6^tm1Des/Itgb6^tm1Des
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6^tm1Des mutation (0 available); any Itgb6 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Juvenile baldness in Itgb6^tm1Des/Itgb6^tm1Des mice

respiratory system

respiratory system inflammation ( J:33139 )

• mice exhibit increased airway responsiveness to acetylcholine

abnormal lung morphology ( J:33139 )

• mononuclear cells consisting of a mixed lymphocyte infiltrate are present in the lung epithelium

• however, mice do not display any overt signs of lung infection

immune system

respiratory system inflammation ( J:33139 )

• mice exhibit increased airway responsiveness to acetylcholine

integument

alopecia ( J:33139 )

• mice fail to develop hair on the tops of their heads, the backs of their necks and the inner surface of their thighs

• however, by 20 to 30 days hair growth on the head and neck resumes

abnormal hair follicle morphology ( J:33139 )

• degenerating follicle cells are surrounded by mononuclear cells consisting of a macrophage infiltrate

decreased hair follicle number ( J:33139 )

• mixed cellular infiltration of dermis, macrophages; mixed cellular infiltration of airway walls, mixed lymphocytes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
asthma		DOID:2841	OMIM:600807	J:33139

Allelic Composition	Itgb6^tm1Des/Itgb6^tm1Des
Genetic Background	involves: 129T2/SvEms

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6^tm1Des mutation (0 available); any Itgb6 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

overexpanded pulmonary alveolus ( J:89578 )

• normal alveolar size at 2 months of age, however spontaneously developed progressive alveolar enlargement over time

emphysema ( J:89578 )

• developed pulmonary emphysema over time

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pulmonary emphysema		DOID:9675	OMIM:130700	J:89578

Allelic Composition	Itgb6^tm1Des/Itgb6^tm1Des Mmp12^tm1Sds/Mmp12^tm1Sds
Genetic Background	involves: 129/Sv * 129T2/SvEms

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6^tm1Des mutation (0 available); any Itgb6 mutation (32 available)
Mmp12^tm1Sds mutation (1 available); any Mmp12 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

lung inflammation ( J:89578 )

• degree of lung inflammation was similar to that in single homozygous Itgb6 mutant mice

respiratory system

respiratory system phenotype ( J:89578 )

N	• did not exhibit alveolar enlargement and did not develop emphysema

lung inflammation ( J:89578 )

• degree of lung inflammation was similar to that in single homozygous Itgb6 mutant mice

integument

alopecia ( J:89578 )

• developed patchy juvenile baldness associated with skin inflammation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	pulmonary emphysema	DOID:9675	OMIM:130700	J:89578

Allelic Composition	Itgb6^tm1Des/Itgb6^tm1Des Tg(SFTPC-ITGB6)1Des/?
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6^tm1Des mutation (0 available); any Itgb6 mutation (32 available)
Tg(SFTPC-ITGB6)1Des mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

respiratory system phenotype ( J:51592 )

N	• bronchoalveolar lavage abnormalities are largely corrected

respiratory system inflammation ( J:51592 )

• accumulation of lymphocytes around conducting airways and adjacent veins found in 6 of 14 mice examined

• less frequent than in mice only homozygous for Itgb6^tm1Des

immune system

respiratory system inflammation ( J:51592 )

• accumulation of lymphocytes around conducting airways and adjacent veins found in 6 of 14 mice examined

• less frequent than in mice only homozygous for Itgb6^tm1Des

integument

alopecia ( J:51592 )

• inflammatory baldness observed

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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