All Phenotypes Igf1r<tm1Arge> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igf1r^tm1Arge
targeted mutation 1, Argiris Efstratiadis
MGI:1926486

Summary

37 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igf1r^tm1Arge/Igf1r^tm1Arge	involves: 129S/SvEv	MGI:2175079
hm2	Igf1r^tm1Arge/Igf1r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820293
hm3	Igf1r^tm1Arge/Igf1r^tm1Arge	involves: 129/Sv * 129S/SvEv	MGI:3820244
ht4	Igf1r^tm1Arge/Igf1r⁺	involves: 129S/SvEv	MGI:2175080
cn5	Igf1r^tm1Arge/Igf1r^tm2Arge Tg(Camk2a-cre)2Szi/0	involves: 129S/SvEv * C57BL/6J * CBA	MGI:3038640
cx6	Igf1^tm1Arge/Igf1^tm1Arge Igf1r^tm1Arge/Igf1r^tm1Arge	either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)	MGI:3629674
cx7	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv	MGI:3629680
cx8	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr^tm1Dac Insrr^tm1Dac/Insrr^tm1Dac	involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J	MGI:3575085
cx9	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr⁺ Insrr^tm1Dac/Insrr^tm1Dac	involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J	MGI:3575092
cx10	Gpc3^tm1Arge/Gpc3^tm1Arge Igf1r^tm1Arge/Igf1r^tm1Arge	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3629890
cx11	Gpc3^tm1Arge/Y Igf1r^tm1Arge/Igf1r^tm1Arge	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3629887
cx12	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr^tm1Dac	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J	MGI:3575098
cx13	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820256
cx14	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820255
cx15	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820257
cx16	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820258
cx17	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820259
cx18	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820260
cx19	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820261
cx20	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820262
cx21	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820263
cx22	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820287
cx23	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820288
cx24	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820289
cx25	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820290
cx26	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv	MGI:3820239
cx27	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129S/SvEv	MGI:3820231
cx28	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv	MGI:3820232
cx29	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv	MGI:3820233
cx30	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129S/SvEv	MGI:3820234
cx31	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129S/SvEv	MGI:3820236
cx32	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129S/SvEv	MGI:3820237
cx33	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv	MGI:3820238
cx34	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1	MGI:3820218
cx35	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1	MGI:3820219
cx36	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1	MGI:3820217
cx37	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1	MGI:3820220

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:15108 )

• born alive but die within minutes after birth

growth/size/body

decreased birth weight ( J:15108 )

• birth weight is about 45% of wild-type

muscle

muscle hypoplasia ( J:15108 )

• reduction in number of myocytes in the three layers of the anterolateral abdominal muscle and in neck, limb, and respiratory muscles

respiratory system

atelectasis ( J:15108 )

• lung tissue fails to float on water, indicating that air never reached the alveoli

respiratory failure ( J:15108 )

• failure at birth

skeleton

delayed bone ossification ( J:15108 )

• ossification centers of cranial and facial bones appear later, after about a lag of 2 days, except for the interparietal bone, which exhibits an even longer delay of about 4 days

• developmental delay in the bones of the trunk and extremities is 1-2 days

nervous system

decreased oligodendrocyte progenitor number ( J:15108 )

• fewer oligodendrocyte progenitors develop in cultured E18.5 forebrain cells

abnormal brainstem morphology ( J:15108 )

• increase in cell density in the brainstem

abnormal spinal cord morphology ( J:15108 )

• cellular density in the mantle zone is higher at E14.5-E18.5

homeostasis/metabolism

cyanosis ( J:15108 )

• mutants are born alive but become cyanotic and die within minutes

integument

abnormal hair follicle morphology ( J:15108 )

• hair follicles are more widely spaced than in wild-type

decreased hair follicle number ( J:15108 )

• decrease in the absolute number of hair follicles

small hair follicles ( J:15108 )

thin epidermis stratum spinosum ( J:15108 )

thin epidermis ( J:15108 )

• the strata of the epidermis (basale, spinosum, granulosum, and corneum) is extremely thin

translucent skin ( J:15108 )

cellular

decreased oligodendrocyte progenitor number ( J:15108 )

• fewer oligodendrocyte progenitors develop in cultured E18.5 forebrain cells

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 45.9% of wild-type

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 47% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal postnatal growth/weight/body size ( J:15108 )

• retardation

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm2Arge Tg(Camk2a-cre)2Szi/0
Genetic Background	involves: 129S/SvEv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)
Igf1r^tm2Arge mutation (1 available); any Igf1r mutation (88 available)
Tg(Camk2a-cre)2Szi mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased oligodendrocyte progenitor number ( J:88198 )

• oligodendrocyte progenitor cells fail to proliferate and an increase in apoptosis is seen in the middle region of the corpus callosum following cuprizone exposure

abnormal CNS glial cell morphology ( J:88198 )

• micoglia/macrophages persist in the middle region of the corpus callosum in mutants 9 weeks after cuprizone exposure but not in wild-types

abnormal oligodendrocyte morphology ( J:88198 )

• mature oligodendrocyte fail to regenerate in the middle region of the corpus callosum following cuprizone exposure

abnormal myelination ( J:88198 )

• 9 and 14 weeks after cuprizone induced demyelination, remyelination is absent in the middle region of the corpus callosum of the forebrain in mutants

• 9 and 14 weeks after cuprizone induced demyelination, remyelination has occurred in the extreme ventral and dorsal edges of the callosum in mutants and throughout the corpus callosum in wild-types

• prior to cuprizone treatment myelination is normal in mutants

cellular

decreased oligodendrocyte progenitor number ( J:88198 )

• oligodendrocyte progenitor cells fail to proliferate and an increase in apoptosis is seen in the middle region of the corpus callosum following cuprizone exposure

Allelic Composition	Igf1^tm1Arge/Igf1^tm1Arge Igf1r^tm1Arge/Igf1r^tm1Arge
Genetic Background	either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)
Igf1^tm1Arge mutation (2 available); any Igf1 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:15108 )

• die immediately after birth of respiratory failure

growth/size/body

decreased birth weight ( J:15108 )

• birth weight is about 45% of wild-type

respiratory system

respiratory failure ( J:15108 )

skeleton

delayed bone ossification ( J:15108 )

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:15108 )

• double mutants with a paternally inherited Igf2 allele die immediately after birth of respiratory failure

growth/size/body

decreased birth weight ( J:15108 )

• birth weight is about 30% of wild-type in double mutants with a paternally inherited Igf2 allele

nervous system

abnormal nervous system morphology ( J:15108 )

• the central nervous system of double mutants with a paternally inherited Igf2 allele exhibits the same high cellular density seen in Igf1r single mutants

respiratory system

respiratory failure ( J:15108 )

skeleton

delayed bone ossification ( J:15108 )

• delays in bone development are somewhat more pronounced in double mutants with a paternally inherited Igf2 allele than in Igf1r single mutants

cellular

maternal imprinting ( J:15108 )

• defects are seen in double mutants with a paternally inherited Igf2 allele

integument

abnormal epidermal layer morphology ( J:15108 )

• double mutants with a paternally inherited Igf2 allele exhibit an underdeveloped epidermis similar to that seen in Igf1r single mutants

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr^tm1Dac Insrr^tm1Dac/Insrr^tm1Dac
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)
Insrr^tm1Dac mutation (0 available); any Insrr mutation (62 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal primary sex determination ( J:86618 )

primary sex reversal ( J:86618 )

• XY mice at E17.5 showed gonad location and histology consistent with ovary development

• cause inferred as decrease in proliferation of Sry -expressing cells

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr⁺ Insrr^tm1Dac/Insrr^tm1Dac
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal primary sex determination ( J:86618 )

primary sex reversal ( J:86618 )

• XY mice may develop testes, ovotestes, and/or ovaries

• gonad type is suggested by degree of gonadal descent and histological analyses

Allelic Composition	Gpc3^tm1Arge/Gpc3^tm1Arge Igf1r^tm1Arge/Igf1r^tm1Arge
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3^tm1Arge mutation (0 available); any Gpc3 mutation (18 available)
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:75054 )

• mutants are stillborn

limbs/digits/tail

abnormal calcaneum morphology ( J:75054 )

• the calcaneus is not positioned at an angle with respect to the tibia resulting in a club foot like phenotype

abnormal hindlimb morphology ( J:75054 )

• 9 of 14 exhibit a hindlimb defect resembling club foot; the hind paws are abnormally bent medially with respect to the axis of the tibia

skeleton

abnormal calcaneum morphology ( J:75054 )

• the calcaneus is not positioned at an angle with respect to the tibia resulting in a club foot like phenotype

Allelic Composition	Gpc3^tm1Arge/Y Igf1r^tm1Arge/Igf1r^tm1Arge
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:75054 )

• mutants are stillborn

limbs/digits/tail

abnormal calcaneum morphology ( J:75054 )

• the calcaneus is not positioned at an angle with respect to the tibia resulting in a club foot like phenotype

abnormal hindlimb morphology ( J:75054 )

• 9 of 14 exhibit a hindlimb defect resembling club foot; the hind paws are abnormally bent medially with respect to the axis of the tibia

skeleton

abnormal calcaneum morphology ( J:75054 )

• the calcaneus is not positioned at an angle with respect to the tibia resulting in a club foot like phenotype

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr^tm1Dac
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

ovotestis ( J:86618 )

• determined by partial descent of gonads and histological analyses showing ovarian and testicular tissue

primary sex reversal ( J:86618 )

• partial male-to-female sex reversal is observed

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 33.6% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)
Igf2r^tm2Arge mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, placenta size is 67% of normal at E18.5

• when Igf2^tm1Rob and Igf2r^tm2Arge are inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, birth weight is 34.4% of normal

• when Igf2^tm1Rob and Igf2r^tm2Arge are inherited paternally, birth weight is 33.6% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, birth weight is 33.6% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, birth weight is 34.4% of normal

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited paternally, birth weight is 33.6% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased birth weight ( J:34584 )

• birth weight is 109% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm2Arge is inherited paternally, birth weight is 45.9% of wild-type

increased birth weight ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, birth weight is 109% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased birth weight ( J:34584 )

• birth weight is 109% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited paternally, birth weight is 45.9% of wild-type

increased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 109% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2r^tm1Arge is inherited maternally, survival is normal

reproductive system

decreased litter size ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice exhibit decreased litter size due to decreased maternal care

• however, litter survival can be increased by fostering pups

embryo

enlarged placenta ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally

behavior/neurological

abnormal maternal nurturing ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, females do not care for their neonates whose survival can be increased by fostering

growth/size/body

growth/size/body region phenotype ( J:34584 )

N	• when Igf2r^tm1Arge is inherited maternally, birth weight is normal

decreased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited paternally, birth weight is 47% of normal

slow postnatal weight gain ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice exhibit reduced growth after P1 but catch up by P70

Allelic Composition	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• most mice die perinatally with some exceptions

perinatal lethality, incomplete penetrance ( J:34584 )

• most mice die perinatally with some exceptions

growth/size/body

increased birth weight ( J:34584 )

• birth weight is 135% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, most mice die perinatally with some exceptions

perinatal lethality, incomplete penetrance ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, most mice die perinatally with some exceptions

growth/size/body

increased birth weight ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, birth weight is 135% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, most mice die perinatally with some exceptions

perinatal lethality, incomplete penetrance ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, most mice die perinatally with some exceptions

growth/size/body

increased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 135% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• most mice die perinatally with some exceptions

perinatal lethality, incomplete penetrance ( J:34584 )

• most mice die perinatally with some exceptions

growth/size/body

increased birth weight ( J:34584 )

• birth weight is 135% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• survival is normal

reproductive system

decreased litter size ( J:34584 )

• mice exhibit decreased litter size due to decreased maternal care

• however, litter survival can be increased by fostering pups

embryo

enlarged placenta ( J:34584 )

behavior/neurological

abnormal maternal nurturing ( J:34584 )

• females do not care for their neonates whose survival can be increased by fostering

growth/size/body

growth/size/body region phenotype ( J:34584 )

N	• birth weight is normal

slow postnatal weight gain ( J:34584 )

• mice exhibit reduced growth after P1 but catch up by P70

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• survival is normal

reproductive system

decreased litter size ( J:34584 )

• mice exhibit decreased litter size due to decreased maternal care

• however, litter survival can be increased by fostering pups

embryo

enlarged placenta ( J:34584 )

behavior/neurological

abnormal maternal nurturing ( J:34584 )

• females do not care for their neonates whose survival can be increased by fostering

growth/size/body

growth/size/body region phenotype ( J:34584 )

N	• birth weight is normal

slow postnatal weight gain ( J:34584 )

• mice exhibit reduced growth after P1 but catch up by P70

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2r^tm2Arge is inherited maternally, survival is normal

reproductive system

decreased litter size ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, mice exhibit decreased litter size due to decreased maternal care

• however, litter survival can be increased by fostering pups

embryo

enlarged placenta ( J:34584 )

• when this allele is inherited maternally

behavior/neurological

abnormal maternal nurturing ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, females do not care for their neonates whose survival can be increased by fostering

growth/size/body

growth/size/body region phenotype ( J:34584 )

N	• when Igf2r^tm2Arge is inherited maternally, birth weight is normal

decreased birth weight ( J:34584 )

• when Igf2r^tm2Arge is inherited paternally, birth weight is 47% of normal

slow postnatal weight gain ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, mice exhibit reduced growth after P1 but catch up by P70

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, 7.3% of mice survive postnatally

postnatal lethality, incomplete penetrance ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, 7.3% of mice survive postnatally

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• 3.7% of mice survive postnatally

postnatal lethality, incomplete penetrance ( J:34586 )

• 3.7% of mice survive postnatally

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when this allele is inherited maternally, 7.3% of mice survive postnatally

postnatal lethality, incomplete penetrance ( J:34584 )

• when this allele is inherited maternally, 7.3% of mice survive postnatally

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• 3.7% of mice survive postnatally

postnatal lethality, incomplete penetrance ( J:34584 )

• 3.7% of mice survive postnatally

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