All Phenotypes Igf1r<tm1Arge> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igf1r^tm1Arge
targeted mutation 1, Argiris Efstratiadis
MGI:1926486

Summary

37 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igf1r^tm1Arge/Igf1r^tm1Arge	involves: 129S/SvEv	MGI:2175079
hm2	Igf1r^tm1Arge/Igf1r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820293
hm3	Igf1r^tm1Arge/Igf1r^tm1Arge	involves: 129/Sv * 129S/SvEv	MGI:3820244
ht4	Igf1r^tm1Arge/Igf1r⁺	involves: 129S/SvEv	MGI:2175080
cn5	Igf1r^tm1Arge/Igf1r^tm2Arge Tg(Camk2a-cre)2Szi/0	involves: 129S/SvEv * C57BL/6J * CBA	MGI:3038640
cx6	Igf1^tm1Arge/Igf1^tm1Arge Igf1r^tm1Arge/Igf1r^tm1Arge	either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)	MGI:3629674
cx7	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv	MGI:3629680
cx8	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr^tm1Dac Insrr^tm1Dac/Insrr^tm1Dac	involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J	MGI:3575085
cx9	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr⁺ Insrr^tm1Dac/Insrr^tm1Dac	involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J	MGI:3575092
cx10	Gpc3^tm1Arge/Gpc3^tm1Arge Igf1r^tm1Arge/Igf1r^tm1Arge	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3629890
cx11	Gpc3^tm1Arge/Y Igf1r^tm1Arge/Igf1r^tm1Arge	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3629887
cx12	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr^tm1Dac	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J	MGI:3575098
cx13	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820256
cx14	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820255
cx15	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820257
cx16	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820258
cx17	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820259
cx18	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820260
cx19	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820261
cx20	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820262
cx21	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820263
cx22	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820287
cx23	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820288
cx24	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820289
cx25	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820290
cx26	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv	MGI:3820239
cx27	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129S/SvEv	MGI:3820231
cx28	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv	MGI:3820232
cx29	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv	MGI:3820233
cx30	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129S/SvEv	MGI:3820234
cx31	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129S/SvEv	MGI:3820236
cx32	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129S/SvEv	MGI:3820237
cx33	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv	MGI:3820238
cx34	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1	MGI:3820218
cx35	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1	MGI:3820219
cx36	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1	MGI:3820217
cx37	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1	MGI:3820220

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:15108 )

• born alive but die within minutes after birth

growth/size/body

decreased birth weight ( J:15108 )

• birth weight is about 45% of wild-type

muscle

muscle hypoplasia ( J:15108 )

• reduction in number of myocytes in the three layers of the anterolateral abdominal muscle and in neck, limb, and respiratory muscles

respiratory system

atelectasis ( J:15108 )

• lung tissue fails to float on water, indicating that air never reached the alveoli

respiratory failure ( J:15108 )

• failure at birth

skeleton

delayed bone ossification ( J:15108 )

• ossification centers of cranial and facial bones appear later, after about a lag of 2 days, except for the interparietal bone, which exhibits an even longer delay of about 4 days

• developmental delay in the bones of the trunk and extremities is 1-2 days

nervous system

decreased oligodendrocyte progenitor number ( J:15108 )

• fewer oligodendrocyte progenitors develop in cultured E18.5 forebrain cells

abnormal brainstem morphology ( J:15108 )

• increase in cell density in the brainstem

abnormal spinal cord morphology ( J:15108 )

• cellular density in the mantle zone is higher at E14.5-E18.5

homeostasis/metabolism

cyanosis ( J:15108 )

• mutants are born alive but become cyanotic and die within minutes

integument

abnormal hair follicle morphology ( J:15108 )

• hair follicles are more widely spaced than in wild-type

decreased hair follicle number ( J:15108 )

• decrease in the absolute number of hair follicles

small hair follicles ( J:15108 )

thin epidermis stratum spinosum ( J:15108 )

thin epidermis ( J:15108 )

• the strata of the epidermis (basale, spinosum, granulosum, and corneum) is extremely thin

translucent skin ( J:15108 )

cellular

decreased oligodendrocyte progenitor number ( J:15108 )

• fewer oligodendrocyte progenitors develop in cultured E18.5 forebrain cells

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 45.9% of wild-type

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 47% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal postnatal growth/weight/body size ( J:15108 )

• retardation

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm2Arge Tg(Camk2a-cre)2Szi/0
Genetic Background	involves: 129S/SvEv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (85 available)
Igf1r^tm2Arge mutation (1 available); any Igf1r mutation (85 available)
Tg(Camk2a-cre)2Szi mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased oligodendrocyte progenitor number ( J:88198 )

• oligodendrocyte progenitor cells fail to proliferate and an increase in apoptosis is seen in the middle region of the corpus callosum following cuprizone exposure

abnormal CNS glial cell morphology ( J:88198 )

• micoglia/macrophages persist in the middle region of the corpus callosum in mutants 9 weeks after cuprizone exposure but not in wild-types

abnormal oligodendrocyte morphology ( J:88198 )

• mature oligodendrocyte fail to regenerate in the middle region of the corpus callosum following cuprizone exposure

abnormal myelination ( J:88198 )

• 9 and 14 weeks after cuprizone induced demyelination, remyelination is absent in the middle region of the corpus callosum of the forebrain in mutants

• 9 and 14 weeks after cuprizone induced demyelination, remyelination has occurred in the extreme ventral and dorsal edges of the callosum in mutants and throughout the corpus callosum in wild-types

• prior to cuprizone treatment myelination is normal in mutants

cellular

decreased oligodendrocyte progenitor number ( J:88198 )

• oligodendrocyte progenitor cells fail to proliferate and an increase in apoptosis is seen in the middle region of the corpus callosum following cuprizone exposure

Allelic Composition	Igf1^tm1Arge/Igf1^tm1Arge Igf1r^tm1Arge/Igf1r^tm1Arge
Genetic Background	either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (85 available)
Igf1^tm1Arge mutation (2 available); any Igf1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:15108 )

• die immediately after birth of respiratory failure

growth/size/body

decreased birth weight ( J:15108 )

• birth weight is about 45% of wild-type

respiratory system

respiratory failure ( J:15108 )

skeleton

delayed bone ossification ( J:15108 )

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (85 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:15108 )

• double mutants with a paternally inherited Igf2 allele die immediately after birth of respiratory failure

growth/size/body

decreased birth weight ( J:15108 )

• birth weight is about 30% of wild-type in double mutants with a paternally inherited Igf2 allele

nervous system

abnormal nervous system morphology ( J:15108 )

• the central nervous system of double mutants with a paternally inherited Igf2 allele exhibits the same high cellular density seen in Igf1r single mutants

respiratory system

respiratory failure ( J:15108 )

skeleton

delayed bone ossification ( J:15108 )

• delays in bone development are somewhat more pronounced in double mutants with a paternally inherited Igf2 allele than in Igf1r single mutants

cellular

maternal imprinting ( J:15108 )

• defects are seen in double mutants with a paternally inherited Igf2 allele

integument

abnormal epidermal layer morphology ( J:15108 )

• double mutants with a paternally inherited Igf2 allele exhibit an underdeveloped epidermis similar to that seen in Igf1r single mutants

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr^tm1Dac Insrr^tm1Dac/Insrr^tm1Dac
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (85 available)
Insrr^tm1Dac mutation (0 available); any Insrr mutation (62 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal primary sex determination ( J:86618 )

primary sex reversal ( J:86618 )

• XY mice at E17.5 showed gonad location and histology consistent with ovary development

• cause inferred as decrease in proliferation of Sry -expressing cells

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr⁺ Insrr^tm1Dac/Insrr^tm1Dac
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal primary sex determination ( J:86618 )

primary sex reversal ( J:86618 )

• XY mice may develop testes, ovotestes, and/or ovaries

• gonad type is suggested by degree of gonadal descent and histological analyses

Allelic Composition	Gpc3^tm1Arge/Gpc3^tm1Arge Igf1r^tm1Arge/Igf1r^tm1Arge
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3^tm1Arge mutation (0 available); any Gpc3 mutation (17 available)
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:75054 )

• mutants are stillborn

limbs/digits/tail

abnormal calcaneum morphology ( J:75054 )

• the calcaneus is not positioned at an angle with respect to the tibia resulting in a club foot like phenotype

abnormal hindlimb morphology ( J:75054 )

• 9 of 14 exhibit a hindlimb defect resembling club foot; the hind paws are abnormally bent medially with respect to the axis of the tibia

skeleton

abnormal calcaneum morphology ( J:75054 )

• the calcaneus is not positioned at an angle with respect to the tibia resulting in a club foot like phenotype

Allelic Composition	Gpc3^tm1Arge/Y Igf1r^tm1Arge/Igf1r^tm1Arge
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:75054 )

• mutants are stillborn

limbs/digits/tail

abnormal calcaneum morphology ( J:75054 )

• the calcaneus is not positioned at an angle with respect to the tibia resulting in a club foot like phenotype

abnormal hindlimb morphology ( J:75054 )

• 9 of 14 exhibit a hindlimb defect resembling club foot; the hind paws are abnormally bent medially with respect to the axis of the tibia

skeleton

abnormal calcaneum morphology ( J:75054 )

• the calcaneus is not positioned at an angle with respect to the tibia resulting in a club foot like phenotype

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Insr^tm1Dac/Insr^tm1Dac
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (85 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

ovotestis ( J:86618 )

• determined by partial descent of gonads and histological analyses showing ovarian and testicular tissue

primary sex reversal ( J:86618 )

• partial male-to-female sex reversal is observed

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 33.6% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (85 available)
Igf2r^tm2Arge mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, placenta size is 67% of normal at E18.5

• when Igf2^tm1Rob and Igf2r^tm2Arge are inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, birth weight is 34.4% of normal

• when Igf2^tm1Rob and Igf2r^tm2Arge are inherited paternally, birth weight is 33.6% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, birth weight is 33.6% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (85 available)
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, birth weight is 34.4% of normal

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited paternally, birth weight is 33.6% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased birth weight ( J:34584 )

• birth weight is 109% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm2Arge is inherited paternally, birth weight is 45.9% of wild-type

increased birth weight ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, birth weight is 109% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased birth weight ( J:34584 )

• birth weight is 109% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited paternally, birth weight is 45.9% of wild-type

increased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 109% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2r^tm1Arge is inherited maternally, survival is normal

reproductive system

decreased litter size ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice exhibit decreased litter size due to decreased maternal care

• however, litter survival can be increased by fostering pups

embryo

enlarged placenta ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally

behavior/neurological

abnormal maternal nurturing ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, females do not care for their neonates whose survival can be increased by fostering

growth/size/body

growth/size/body region phenotype ( J:34584 )

N	• when Igf2r^tm1Arge is inherited maternally, birth weight is normal

decreased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited paternally, birth weight is 47% of normal

slow postnatal weight gain ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice exhibit reduced growth after P1 but catch up by P70

Allelic Composition	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• most mice die perinatally with some exceptions

perinatal lethality, incomplete penetrance ( J:34584 )

• most mice die perinatally with some exceptions

growth/size/body

increased birth weight ( J:34584 )

• birth weight is 135% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, most mice die perinatally with some exceptions

perinatal lethality, incomplete penetrance ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, most mice die perinatally with some exceptions

growth/size/body

increased birth weight ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, birth weight is 135% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, most mice die perinatally with some exceptions

perinatal lethality, incomplete penetrance ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, most mice die perinatally with some exceptions

growth/size/body

increased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 135% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r⁺ Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• most mice die perinatally with some exceptions

perinatal lethality, incomplete penetrance ( J:34584 )

• most mice die perinatally with some exceptions

growth/size/body

increased birth weight ( J:34584 )

• birth weight is 135% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• survival is normal

reproductive system

decreased litter size ( J:34584 )

• mice exhibit decreased litter size due to decreased maternal care

• however, litter survival can be increased by fostering pups

embryo

enlarged placenta ( J:34584 )

behavior/neurological

abnormal maternal nurturing ( J:34584 )

• females do not care for their neonates whose survival can be increased by fostering

growth/size/body

growth/size/body region phenotype ( J:34584 )

N	• birth weight is normal

slow postnatal weight gain ( J:34584 )

• mice exhibit reduced growth after P1 but catch up by P70

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• survival is normal

reproductive system

decreased litter size ( J:34584 )

• mice exhibit decreased litter size due to decreased maternal care

• however, litter survival can be increased by fostering pups

embryo

enlarged placenta ( J:34584 )

behavior/neurological

abnormal maternal nurturing ( J:34584 )

• females do not care for their neonates whose survival can be increased by fostering

growth/size/body

growth/size/body region phenotype ( J:34584 )

N	• birth weight is normal

slow postnatal weight gain ( J:34584 )

• mice exhibit reduced growth after P1 but catch up by P70

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2r^tm2Arge is inherited maternally, survival is normal

reproductive system

decreased litter size ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, mice exhibit decreased litter size due to decreased maternal care

• however, litter survival can be increased by fostering pups

embryo

enlarged placenta ( J:34584 )

• when this allele is inherited maternally

behavior/neurological

abnormal maternal nurturing ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, females do not care for their neonates whose survival can be increased by fostering

growth/size/body

growth/size/body region phenotype ( J:34584 )

N	• when Igf2r^tm2Arge is inherited maternally, birth weight is normal

decreased birth weight ( J:34584 )

• when Igf2r^tm2Arge is inherited paternally, birth weight is 47% of normal

slow postnatal weight gain ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, mice exhibit reduced growth after P1 but catch up by P70

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, 7.3% of mice survive postnatally

postnatal lethality, incomplete penetrance ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, 7.3% of mice survive postnatally

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• 3.7% of mice survive postnatally

postnatal lethality, incomplete penetrance ( J:34586 )

• 3.7% of mice survive postnatally

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• when this allele is inherited maternally, 7.3% of mice survive postnatally

postnatal lethality, incomplete penetrance ( J:34584 )

• when this allele is inherited maternally, 7.3% of mice survive postnatally

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:34584 )

• 3.7% of mice survive postnatally

postnatal lethality, incomplete penetrance ( J:34584 )

• 3.7% of mice survive postnatally

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24