Phenotypes associated with this allele

• Allele Symbol: Tg(ITGA2)1070Fmw
• Allele Name: transgene insertion 1070, Fiona M Watt
• Allele ID: MGI:1926491
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(ITGA2)1070Fmw/0 Tg(ITGB1)0840Fmw/0	involves: C57BL/10 * CBA	MGI:3583542
cx2	Tg(ITGA2)1070Fmw/0 Tg(ITGB1)0870Fmw/0	involves: C57BL/10 * CBA	MGI:3583543
cx3	Tg(ITGA2)1070Fmw/0 Tg(ITGB1)0869Fmw/0	involves: C57BL/10 * CBA	MGI:3583544
tg4	Tg(ITGA2)1070Fmw/0	involves: C57BL/10 * CBA	MGI:3583537

Genotype
MGI:3583542

cx1

• Allelic Composition: Tg(ITGA2)1070Fmw/0; Tg(ITGB1)0840Fmw/0
• Genetic Background: involves: C57BL/10 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

eye inflammation ( J:30249 )

• exudate in cornea and eyelid, neonate

cornea scarring ( J:30249 )

• adult

eyelids open at birth ( J:30249 )

increased opacity of vitreous body ( J:30249 )

• adult

immune system

eye inflammation ( J:30249 )

• exudate in cornea and eyelid, neonate

dermatitis ( J:30249 )

• age of onset 6 weeks, episodic

endocrine/exocrine glands

enlarged sebaceous gland ( J:30249 )

integument

enlarged sebaceous gland ( J:30249 )

dermatitis ( J:30249 )

• age of onset 6 weeks, episodic

abnormal coat/ hair morphology ( J:30249 )

waved hair ( J:30249 )

abnormal hair follicle orientation ( J:30249 )

enlarged hair follicles ( J:30249 )

curly vibrissae ( J:30249 )

short vibrissae ( J:30249 )

abnormal skin morphology ( J:30249 )

hyperkeratosis ( J:30249 )

flaky skin ( J:30249 )

• age of onset 6 weeks, episodic

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis		DOID:8893	OMIM:PS177900	J:30249

Genotype
MGI:3583543

cx2

• Allelic Composition: Tg(ITGA2)1070Fmw/0; Tg(ITGB1)0870Fmw/0
• Genetic Background: involves: C57BL/10 * CBA

vision/eye

eye inflammation ( J:30249 )

• exudate in cornea and eyelid, neonate

cornea scarring ( J:30249 )

• adult

eyelids open at birth ( J:30249 )

increased opacity of vitreous body ( J:30249 )

• adult

immune system

eye inflammation ( J:30249 )

• exudate in cornea and eyelid, neonate

dermatitis ( J:30249 )

• age of onset 6 weeks, episodic

endocrine/exocrine glands

enlarged sebaceous gland ( J:30249 )

integument

enlarged sebaceous gland ( J:30249 )

dermatitis ( J:30249 )

• age of onset 6 weeks, episodic

abnormal coat/ hair morphology ( J:30249 )

waved hair ( J:30249 )

abnormal hair follicle orientation ( J:30249 )

enlarged hair follicles ( J:30249 )

curly vibrissae ( J:30249 )

short vibrissae ( J:30249 )

abnormal skin morphology ( J:30249 )

hyperkeratosis ( J:30249 )

flaky skin ( J:30249 )

• age of onset 6 weeks, episodic

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis		DOID:8893	OMIM:PS177900	J:30249

Genotype
MGI:3583544

cx3

• Allelic Composition: Tg(ITGA2)1070Fmw/0; Tg(ITGB1)0869Fmw/0
• Genetic Background: involves: C57BL/10 * CBA

vision/eye

eye inflammation ( J:30249 )

• exudate in cornea and eyelid, neonate

cornea scarring ( J:30249 )

• adult

eyelids open at birth ( J:30249 )

increased opacity of vitreous body ( J:30249 )

• adult

immune system

eye inflammation ( J:30249 )

• exudate in cornea and eyelid, neonate

dermatitis ( J:30249 )

• age of onset 6 weeks, episodic

endocrine/exocrine glands

enlarged sebaceous gland ( J:30249 )

integument

enlarged sebaceous gland ( J:30249 )

dermatitis ( J:30249 )

• age of onset 6 weeks, episodic

abnormal coat/ hair morphology ( J:30249 )

waved hair ( J:30249 )

abnormal hair follicle orientation ( J:30249 )

enlarged hair follicles ( J:30249 )

curly vibrissae ( J:30249 )

short vibrissae ( J:30249 )

abnormal skin morphology ( J:30249 )

hyperkeratosis ( J:30249 )

flaky skin ( J:30249 )

• age of onset 6 weeks, episodic

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis		DOID:8893	OMIM:PS177900	J:30249

Genotype
MGI:3583537

tg4

• Allelic Composition: Tg(ITGA2)1070Fmw/0
• Genetic Background: involves: C57BL/10 * CBA

normal phenotype

no abnormal phenotype detected ( J:30249 )

• mice display no overt phenotype