Phenotypes associated with this allele

• Allele Symbol: Rora^tm1Mba
• Allele Name: targeted mutation 1, Michael Becker-Andre
• Allele ID: MGI:1926597
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rora^tm1Mba/Rora^tm1Mba	involves: 129P2/OlaHsd * C57BL/6	MGI:2174718

Genotype
MGI:2174718

hm1

• Allelic Composition: Rora^tm1Mba/Rora^tm1Mba
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, incomplete penetrance ( J:46854 )

• about half of mice die shortly after weaning

behavior/neurological

abnormal motor learning ( J:46854 )

• mice have an impaired ability in learning how to hang onto a rotating rod

• mice mainly hang onto the rod as opposed the walking strategy WT mice exclusively use

• ability to stay on rod improves with 10 days of training

limb grasping ( J:46854 )

• is observed in all mice

ataxia ( J:46854 )

• clearly visible in all mice

• mice stumble at a rate 20 times greater than WT mice

impaired coordination ( J:46854 )

• mice fall off an elevated rod on average of 75 seconds compared to over 3 minutes for WT mice

decreased grip strength ( J:46854 )

• mice have a mean hanging time of 77 seconds compared to over 3 minutes for WT mice

nervous system

abnormal cerebellar Purkinje cell layer ( J:46854 )

• the Purkinje cell layer is poorly defined

Purkinje cell degeneration ( J:46854 )

• many cells display an immature phenotype with poorly developed axon termini

abnormal Purkinje cell dendrite morphology ( J:46854 )

• dendrites are smaller than normal, not confined to a single plane, and devoid of spiny branchlets

decreased Purkinje cell number ( J:46854 )

• cells are reduced in number

ectopic Purkinje cell ( J:46854 )

• Purkinje cells are distributed in a diffuse layer

absent cerebellar granule cells ( J:46854 )

• cells are completely absent

thin cerebellar granule layer ( J:46854 )

• layer is very thin with granule cells completely absent

small cerebellum ( J:46854 )

• greatly reduced in size in adult mice, particularly the intermediate region

abnormal excitatory postsynaptic currents ( J:46854 )

• mice fail to display an all-or-none postsynaptic current when the cerebellar granule layer is excited

• instead, the response is dependent on the stimulus intensity

integument

retarded hair growth ( J:46854 )

• when shaved, the hair grows back very slowly

sparse hair ( J:46854 )

• hair is less dense

absent duvet hair ( J:46854 )

• mice lack duvet hair