Phenotypes associated with this allele

• Allele Symbol: Tg(Zfp38)D1Htz
• Allele Name: transgene insertion D1, Nathaniel Heintz
• Allele ID: MGI:1926806
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Zfp38)D1Htz/0	involves: C57BL/6 * CBA	MGI:2174890

Genotype
MGI:2174890

tg1

• Allelic Composition: Tg(Zfp38)D1Htz/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

accelerated formation of intralobular fissures ( J:56546 )

abnormal cerebellar granule layer morphology ( J:56546 )

• 17% increase in the inner granule layer (IGL) area of vermal sections

• increase in cell death in the IGL at P8

increased cerebellar granule cell number ( J:56546 )

• increase in the number of granule cells but no difference in granule cell density

abnormal cerebellum fissure morphology ( J:56546 )

• percentage of cerebella having intralobular fissures is significantly increased

enlarged cerebellum ( J:56546 )

• P10-20 mutants exhibit enlarged cerebellum

integument

epithelioid cyst ( J:56546 )

• frequent epitheloid cysts at P25

alopecia ( J:56546 )

• regional alopecia is observed in 2 of 40 mutants

progressive hair loss ( J:56546 )

• progressive hair loss starting at P17-22

• by P30, growth of new hair occurs in the affected areas but then loss occurs at P50

• regrown hair remains thin

abnormal hair shaft morphology ( J:56546 )

• frequent epithelioid cysts with absent or abnormal hair shafts

abnormal hair follicle morphology ( J:56546 )

• few normal hair follicles at P25 and density of abnormal hair follicles is higher than density of normal hair follicles in wild-type mice

abnormal dermal layer morphology ( J:56546 )

• high cellularity of dermis at P25

abnormal skin development ( J:56546 )

• progenitor cell proliferation is increased in the skin

growth/size/body

epithelioid cyst ( J:56546 )

• frequent epitheloid cysts at P25