All Phenotypes Stat3<tm1Aki> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Stat3^tm1Aki
targeted mutation 1, Shizuo Akira
MGI:1926814

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stat3^tm1Aki/Stat3^tm1Aki	involves: 129P2/OlaHsd	MGI:2174747
cn2	Stat3^tm1Aki/Stat3^tm2Aki Tg(NEFL-cre)50Msd/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1	MGI:4410454
cn3	Stat3^tm1Aki/Stat3^tm1Aki Tg(Tek-cre)12Flv/0	involves: 129P2/OlaHsd * C3H * C57BL/6	MGI:3796175
cn4	Stat3^tm1Aki/Stat3^tm2Aki Tg(Col1a1-cre)1Kry/0	involves: 129P2/OlaHsd * FVB/N * C57BL/6	MGI:3843780
cx5	Il6st^tm1Ern/Il6st^tm1Ern Stat3^tm1Aki/Stat3⁺	involves: 129P2/OlaHsd * 129S1/Sv	MGI:3837309

Allelic Composition	Stat3^tm1Aki/Stat3^tm1Aki
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3^tm1Aki mutation (6 available); any Stat3 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Histological analysis of wild type and Stat3^tm1Aki/Stat3^tm1Aki embryos

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:40106 )

• homozygotes develop into the egg cylinder stage until E6.0 but start undergoing rapid degeneration at E6.5

• all homozygotes are completely resorbed by E7.5

embryo

decreased inner cell mass proliferation ( J:40106 )

• in culture, E3.5 mutant blastocysts exhibit a reduced ICM outgrowth relative to wild-type blastocysts

failure to gastrulate ( J:40106 )

• homozygotes die at ~E7.0, the day at which gastrulation initiates

decreased embryo size ( J:40106 )

• at E6.0, homozygoys mutant embryos are smaller than wild-type embryos

absent mesoderm ( J:40106 )

• homozygotes show absence of mesoderm formation between E6.5 and E7.5

growth/size/body

decreased embryo size ( J:40106 )

• at E6.0, homozygoys mutant embryos are smaller than wild-type embryos

cellular

decreased inner cell mass proliferation ( J:40106 )

• in culture, E3.5 mutant blastocysts exhibit a reduced ICM outgrowth relative to wild-type blastocysts

Allelic Composition	Stat3^tm1Aki/Stat3^tm2Aki Tg(NEFL-cre)50Msd/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3^tm1Aki mutation (6 available); any Stat3 mutation (70 available)
Stat3^tm2Aki mutation (1 available); any Stat3 mutation (70 available)
Tg(NEFL-cre)50Msd mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal motor neuron morphology ( J:77229 )

• motor neurons require higher concentrations of CNTF than wild-type cells to survive in culture

• however, the number of facial and spinal neurons in mice is normal

abnormal neuron physiology ( J:77229 )

• motor neurons require higher concentrations of CNTF than wild-type cells to survive in culture

• however, the number of facial and spinal neurons in mice is normal

homeostasis/metabolism

increased susceptibility to injury ( J:77229 )

• after facial nerve transection, mice exhibit loss of facial motor neurons unlike in similarly treated wild-type mice

• however, treatment with BDNF or CNTF improves neuron survival after facial nerve transection

Allelic Composition	Stat3^tm1Aki/Stat3^tm1Aki Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129P2/OlaHsd * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3^tm1Aki mutation (6 available); any Stat3 mutation (70 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal interleukin level ( J:123351 )

• activated T_H cells from mutants produce no Il-21, Il-17, Il-17F or Il-22

immune system

abnormal interleukin level ( J:123351 )

• activated T_H cells from mutants produce no Il-21, Il-17, Il-17F or Il-22

Allelic Composition	Stat3^tm1Aki/Stat3^tm2Aki Tg(Col1a1-cre)1Kry/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal bone structure ( J:144906 )

• bone volume to tissue volume is reduced by half compared to controls

decreased trabecular bone thickness ( J:144906 )

• trabecular number and trabecular thickness are decreased in the tibia by about a third

• trabecular separation is increased by more than a third

abnormal bone ossification ( J:144906 )

• mineral apposition rate and bone formation rate are significantly reduced in these mice

Allelic Composition	Il6st^tm1Ern/Il6st^tm1Ern Stat3^tm1Aki/Stat3⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Ern mutation (13 available); any Il6st mutation (80 available)
Stat3^tm1Aki mutation (6 available); any Stat3 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:100160 )

N	• improved survival

immune system

immune system phenotype ( J:100160 , J:139226 , J:142883 )

N	• splenomegaly fails to develop (J:100160) • neutrophil infiltration of the peritoneal cavity and subsequent clearance in induced inflammation normal (J:139226) • response to arthritis induced with methylated serum albumin is comparable to control animals (J:142883)

decreased circulating interleukin-6 level ( J:168781 )

• in LPS-treated mice compared with similarly treated Il6st^tm1Ern homozygotes

decreased susceptibility to endotoxin shock ( J:168781 )

• compared with LPS-treated Il6st^tm1Ern homozygotes

digestive/alimentary system

digestive/alimentary phenotype ( J:100160 )

N	• stomach size remains normal

neoplasm

neoplasm ( J:100160 )

N	• numbers of gastric adenomas is reduced

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:168781 )

• in LPS-treated mice compared with similarly treated Il6st^tm1Ern homozygotes

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