All Phenotypes Stat3<tm2Aki> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Stat3^tm2Aki
targeted mutation 2, Shizuo Akira
MGI:1926816

Summary

17 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Stat3^tm2Aki/Stat3^tm2Aki	involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3813250
cn2	Stat3^tm2Aki/Stat3^tm2Aki	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:3714736
cn3	Stat3^tm2Aki/Stat3^tm2Aki Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-cre)1Jaw/0	involves: 129 * 129P2/OlaHsd * C57BL/6	MGI:4888972
cn4	Stat3^tm2Aki/Stat3^tm2Aki Tg(Lck-cre)1Jtak/0	involves: 129P2/OlaHsd	MGI:3770250
cn5	Stat3^tm1Aki/Stat3^tm2Aki Tg(NEFL-cre)50Msd/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1	MGI:4410454
cn6	Il12b^tm1Jm/Il12b^tm1Jm Stat3^tm2Aki/Stat3^tm2Aki Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:3771395
cn7	Stat3^tm2Aki/Stat3^tm2Aki H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor	MGI:5882548
cn8	Fgfr1^tm5.1Sor/Fgfr1^tm10.1Sor Stat3^tm2Aki/Stat3^tm2Aki H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor	MGI:5882547
cn9	Stat3^tm2Aki/Stat3^tm2Aki Tg(KRT5-cre)1Tak/0	involves: 129P2/OlaHsd * C3H * C57BL/6	MGI:5501496
cn10	Stat3^tm2Aki/Stat3^tm2Aki Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3771396
cn11	Stat3^tm2Aki/Stat3^tm2Aki Tlr4^tm1Aki/Tlr4^tm1Aki Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3771394
cn12	Stat3^tm2Aki/Stat3^tm2Aki Tnf^tm1Sek/Tnf^tm1Sek Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3771397
cn13	Stat3^tm2Aki/Stat3^tm2Aki Tg(KRT5-cre/ERT2)AJdg/0	involves: 129P2/OlaHsd * FVB/N	MGI:3807776
cn14	Stat3^tm2Aki/Stat3^tm2Aki Tg(Alb1-cre)1Dlr/0	involves: 129P2/OlaHsd * FVB/N	MGI:3629040
cn15	Stat3^tm1Aki/Stat3^tm2Aki Tg(Col1a1-cre)1Kry/0	involves: 129P2/OlaHsd * FVB/N * C57BL/6	MGI:3843780
cn16	Pdpk1^tm1Maka/Pdpk1^tm1Maka Stat3^tm2Aki/Stat3^tm2Aki Tg(Alb1-cre)1Dlr/0	involves: 129S4/SvJae * 129P2/OlaHsd * FVB/N	MGI:3629039
cn17	Stat1^tm1Rds/Stat1^tm1Rds Stat3^tm2Aki/Stat3^tm2Aki Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3771398

Allelic Composition	Stat3^tm2Aki/Stat3^tm2Aki
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3^tm2Aki mutation (1 available); any Stat3 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

obese ( J:131301 )

• beginning at 5 weeks of age, male mice are almost twice as heavy as Stat3^tm2Aki homozygotes controls and female mice exhibit an increased in body weight compared to Stat3^tm2Aki homozygotes controls

increased body length ( J:131301 )

• at 5 weeks of age, male mice exhibit an increased in body length compared to Stat3^tm2Aki homozygotes controls

• at 10 weeks of age, both male and female mice exhibit an increased in body length compared to Stat3^tm2Aki homozygotes controls

homeostasis/metabolism

increased circulating glucose level ( J:131301 )

• in a fasted state, mice exhibit increased serum glucose levels that correlate to their increase in weight

increased circulating insulin level ( J:131301 )

• fasted males exhibit a 10-fold increase and female mice a more than 20-fold increase in serum insulin levels compared to Stat3^tm2Aki homozygotes controls

behavior/neurological

abnormal eating behavior ( J:131301 )

reproductive system

reproductive system phenotype ( J:131301 )

N	• mice exhibit normal reproduction

Allelic Composition	Stat3^tm2Aki/Stat3^tm2Aki
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3^tm2Aki mutation (1 available); any Stat3 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal response to infection ( J:122213 )

• following Cre recombination and Friend virus (FV) infection, the ability to form Epo-independent colonies is reduced in an in vivo

Allelic Composition	Stat3^tm2Aki/Stat3^tm2Aki Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-cre)1Jaw/0
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3^tm2Aki mutation (1 available); any Stat3 mutation (72 available)
Tg(SFTPC-rtTA)5Jaw mutation (4 available)
Tg(tetO-cre)1Jaw mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:87622 )

N	• under normoxic conditions, mice treated with doxycycline from E0 to P25 exhibit no differences in survival at E18.5 or after birth relative to control littermates

homeostasis/metabolism

abnormal cytokine level ( J:87622 )

• after exposure to hyperoxia, doxycycline-treated mice display increased IL-1beta, IL-6, and MIP-2 levels in lung tissue relative to control littermates

increased susceptibility to injury ( J:87622 )

• when doxycycline is administered from E0 to P25, adult mice are more susceptible to hyperoxia-induced (95% O2 for 65 hrs) lung injury than oxygen-exposed control littermates, displaying an earlier onset of respiratory symptoms, significantly reduced survival, and severe lung injury as shown by hemorrhage, perivascular and lymphatic edema, loss of bronchiolar and alveolar epithelia, severe epithelial cell necrosis, thickened alveoli, extensive inflammation and frequent airspace enlargement

• intratracheal treatment with exogenous surfactant protein B improves survival and lung histology in doxycycline-treated mice 4 days after hyperoxia exposure

respiratory system

respiratory system phenotype ( J:87622 )

N	• under normoxic conditions, mice treated with doxycycline from E0 to P25 exhibit normal lung size and morphology and normal pulmonary mechanics relative to control littermates

abnormal lung vasculature morphology ( J:87622 )

• after exposure to hyperoxia, doxycycline-treated mice display loss of alveolar capillary membrane integrity, perivascular edema, and severe vascular cell necrosis relative to control littermates

lung inflammation ( J:87622 )

• after exposure to hyperoxia, doxycycline-treated mice display increased infiltration by polymorphonuclear cells and alveolar macrophages along with an increased production of IL-1beta, IL-6, and MIP-2 relative to control littermates

abnormal pulmonary alveolus epithelial cell morphology ( J:87622 )

• after exposure to hyperoxia, doxycycline-treated mice display widespread alveolar epithelial cell necrosis without apoptosis, hyaline membrane formation, loss of alveolar capillary membrane integrity, and increased inflammation consistent with severe epithelial cell injury

decreased type II pneumocyte number ( J:87622 )

• after exposure to hyperoxia, staining for proSP-C, a selective marker for type II cells, is decreased in doxycycline-treated mice

pulmonary epithelial necrosis ( J:87622 )

• after exposure to hyperoxia, doxycycline-treated mice display widespread alveolar epithelial cell necrosis without apoptosis

• after exposure to hyperoxia, doxycycline-treated mice display extensive epithelial cell necrosis in the bronchiolar epithelium

pulmonary hyaline membrane formation ( J:87622 )

• after exposure to hyperoxia, doxycycline-treated mice display hyaline membrane formation

increased lung elastance ( J:87622 )

• after exposure to hyperoxia, doxycycline-treated mice display significantly increased lung elastance

increased lung tissue damping ( J:87622 )

• after exposure to hyperoxia, doxycycline-treated mice display significantly increased tissue damping

respiratory distress ( J:87622 )

• doxycycline-treated mice develop acute respiratory distress within 72 hrs of hyperoxia, unlike control littermates which develop severe respiratory symptoms after 5 or more days of continued exposure

abnormal respiratory mechanics ( J:87622 )

• after exposure to hyperoxia, doxycycline-treated mice display altered pulmonary mechanics, indicating a decline in pulmonary function

• however, hysteresivity and newtonian resistance remain unaffected

increased airway resistance ( J:87622 )

• after exposure to hyperoxia, doxycycline-treated mice display a significant increase in airway resistance relative to control littermates

decreased lung compliance ( J:87622 )

• after exposure to hyperoxia, doxycycline-treated mice display reduced lung compliance relative to control littermates

respiratory failure ( J:87622 )

• doxycycline-treated mice exhibit respiratory failure after relatively short periods of hyperoxia

abnormal surfactant secretion ( J:87622 )

• after exposure to hyperoxia, doxycycline-treated mice show significantly increased BALF protein content and reduced alveolar surfactant phospholipid (saturated phosphatidylcholine) pool sizes relative to control littermates

• after exposure to hyperoxia, SP-B is undetectable while SP-A is significantly decreased in alveolar lavage of doxycycline-treated mice

immune system

abnormal cytokine level ( J:87622 )

• after exposure to hyperoxia, doxycycline-treated mice display increased IL-1beta, IL-6, and MIP-2 levels in lung tissue relative to control littermates

lung inflammation ( J:87622 )

cardiovascular system

abnormal lung vasculature morphology ( J:87622 )

• after exposure to hyperoxia, doxycycline-treated mice display loss of alveolar capillary membrane integrity, perivascular edema, and severe vascular cell necrosis relative to control littermates

Allelic Composition	Stat3^tm2Aki/Stat3^tm2Aki Tg(Lck-cre)1Jtak/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3^tm2Aki mutation (1 available); any Stat3 mutation (72 available)
Tg(Lck-cre)1Jtak mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell apoptosis ( J:50443 )

• T cells fail to exhibit an anti-apoptotic effect in response to IL-6 unlike in wild-type mice

decreased T cell proliferation ( J:50443 )

• proliferate in response to IL-6 plus anti-CD3, IL-2 or IL-6 plus ConA stimulation in decreased or absent unlike wild-type mice

• however, proliferation in response to IL-7 is normal

hematopoietic system

increased T cell apoptosis ( J:50443 )

• T cells fail to exhibit an anti-apoptotic effect in response to IL-6 unlike in wild-type mice

decreased T cell proliferation ( J:50443 )

• proliferate in response to IL-6 plus anti-CD3, IL-2 or IL-6 plus ConA stimulation in decreased or absent unlike wild-type mice

• however, proliferation in response to IL-7 is normal

cellular

increased T cell apoptosis ( J:50443 )

• T cells fail to exhibit an anti-apoptotic effect in response to IL-6 unlike in wild-type mice

decreased T cell proliferation ( J:50443 )

• proliferate in response to IL-6 plus anti-CD3, IL-2 or IL-6 plus ConA stimulation in decreased or absent unlike wild-type mice

• however, proliferation in response to IL-7 is normal

Allelic Composition	Stat3^tm1Aki/Stat3^tm2Aki Tg(NEFL-cre)50Msd/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3^tm1Aki mutation (6 available); any Stat3 mutation (72 available)
Stat3^tm2Aki mutation (1 available); any Stat3 mutation (72 available)
Tg(NEFL-cre)50Msd mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal motor neuron morphology ( J:77229 )

• motor neurons require higher concentrations of CNTF than wild-type cells to survive in culture

• however, the number of facial and spinal neurons in mice is normal

abnormal neuron physiology ( J:77229 )

• motor neurons require higher concentrations of CNTF than wild-type cells to survive in culture

• however, the number of facial and spinal neurons in mice is normal

homeostasis/metabolism

increased susceptibility to injury ( J:77229 )

• after facial nerve transection, mice exhibit loss of facial motor neurons unlike in similarly treated wild-type mice

• however, treatment with BDNF or CNTF improves neuron survival after facial nerve transection

Allelic Composition	Il12b^tm1Jm/Il12b^tm1Jm Stat3^tm2Aki/Stat3^tm2Aki Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12b^tm1Jm mutation (4 available); any Il12b mutation (33 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Stat3^tm2Aki mutation (1 available); any Stat3 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:83280 )

N	• mice exhibit normal Th1 responses and do not develop colitis, unlike Stat3 null mice

Allelic Composition	Stat3^tm2Aki/Stat3^tm2Aki H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Stat3^tm2Aki mutation (1 available); any Stat3 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:226497 )

• mice are viable and developmentally normal with no detectable craniofacial abnormalities

Allelic Composition	Fgfr1^tm5.1Sor/Fgfr1^tm10.1Sor Stat3^tm2Aki/Stat3^tm2Aki H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm10.1Sor mutation (1 available); any Fgfr1 mutation (223 available)
Fgfr1^tm5.1Sor mutation (0 available); any Fgfr1 mutation (223 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Stat3^tm2Aki mutation (1 available); any Stat3 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:226497 )

N	• none of the 4 mice examined exhibit cleft palate, likely due to the low penetrance of cleft palate found in Fgfr1^tm5.1Sor/Fgfr1^tm10.1Sor mice (2 of 13)

Allelic Composition	Stat3^tm2Aki/Stat3^tm2Aki Tg(KRT5-cre)1Tak/0
Genetic Background	involves: 129P2/OlaHsd * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3^tm2Aki mutation (1 available); any Stat3 mutation (72 available)
Tg(KRT5-cre)1Tak mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

lacrimal gland inflammation ( J:194832 )

• dacroadenitis

conjunctivitis ( J:194832 )

abnormal eye morphology ( J:194832 )

• periocular disease

immune system

lacrimal gland inflammation ( J:194832 )

• dacroadenitis

conjunctivitis ( J:194832 )

dermatitis ( J:194832 )

• lymphocyte infiltrating periocular dermatitis

integument

decreased keratinocyte migration ( J:65302 )

• keratinocyte migration is impaired

dermatitis ( J:194832 )

• lymphocyte infiltrating periocular dermatitis

abnormal hair follicle morphology ( J:65302 )

• mice exhibit small clustering of matrix cells, which resemble undifferentiated hair germs, distorted or curved hair shafts or gigantic hair bulbs with bizarre shapes

decreased hair follicle number ( J:65302 )

abnormal hair cycle anagen phase ( J:65302 )

• unlike in wild-type mice the second anagen does not occur

hyperkeratosis ( J:65302 )

acanthosis ( J:65302 )

spontaneous skin ulceration ( J:65302 )

• mice exhibit skin ulcerations that worsen with age

skin fibrosis ( J:65302 )

• during the late anagen stage mice exhibit dermal fibrosis with inflammatory infiltrate and atrophic change in adipose tissue

endocrine/exocrine glands

lacrimal gland inflammation ( J:194832 )

• dacroadenitis

cellular

decreased keratinocyte migration ( J:65302 )

• keratinocyte migration is impaired

homeostasis/metabolism

impaired wound healing ( J:65302 )

Allelic Composition	Stat3^tm2Aki/Stat3^tm2Aki Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Stat3^tm2Aki mutation (1 available); any Stat3 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

colitis ( J:83280 )

increased dendritic cell number ( J:83280 )

• in the large intestine

increased CD4-positive, alpha-beta T cell number ( J:83280 )

• splenic interferon-gamma producing CD4+ T cells are increased in mice treated with PMA and ionomycin

increased macrophage cell number ( J:83280 )

• in the large intestine

increased interferon-gamma secretion ( J:83280 )

• CD4+ cells produce increased levels of interferon-gamma

increased interleukin-12 secretion ( J:83280 )

• IL-12 production is enhanced compared to in wild-type mice

digestive/alimentary system

abnormal colon morphology ( J:83280 )

• as early as 5 to 6 weeks, mice exhibit thickened colon walls with reduced glands compared to wild-type mice and by 24 weeks all regions of the colon are affected

colitis ( J:83280 )

hematopoietic system

increased dendritic cell number ( J:83280 )

• in the large intestine

increased CD4-positive, alpha-beta T cell number ( J:83280 )

• splenic interferon-gamma producing CD4+ T cells are increased in mice treated with PMA and ionomycin

increased macrophage cell number ( J:83280 )

• in the large intestine

Allelic Composition	Stat3^tm2Aki/Stat3^tm2Aki Tlr4^tm1Aki/Tlr4^tm1Aki Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

colitis ( J:83280 )

• few mice exhibit inflammation characteristic of colitis and symptoms were less severe than in Stat3 null mice

decreased interferon-gamma secretion ( J:83280 )

• interferon-gamma production is less than in Stat 3 null mice

decreased susceptibility to endotoxin shock ( J:83280 )

• unlike in wild-type mice, LPS fails to induce cytokine production

digestive/alimentary system

colitis ( J:83280 )

• few mice exhibit inflammation characteristic of colitis and symptoms were less severe than in Stat3 null mice

Allelic Composition	Stat3^tm2Aki/Stat3^tm2Aki Tnf^tm1Sek/Tnf^tm1Sek Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

colitis ( J:83280 )

• mice develop enterocolitis that is as severe as in Stat3 null mice

increased interferon-gamma secretion ( J:83280 )

• CD4+ cells produce increased levels of interferon-gamma

increased interleukin-12b secretion ( J:83280 )

• macrophages produce increased amounts of IL-12p40 that are comparable to in Stat3 null mice

increased interleukin-6 secretion ( J:83280 )

• macrophages produce increased amounts of IL-6 that are comparable to in Stat3 null mice

digestive/alimentary system

colitis ( J:83280 )

• mice develop enterocolitis that is as severe as in Stat3 null mice

Allelic Composition	Stat3^tm2Aki/Stat3^tm2Aki Tg(KRT5-cre/ERT2)AJdg/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3^tm2Aki mutation (1 available); any Stat3 mutation (72 available)
Tg(KRT5-cre/ERT2)AJdg mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased apoptosis ( J:138529 )

• DMBA causes increased apoptosis in the epidermis of skin where conditional disruption of Stat3 has been induced by Tamoxifen

neoplasm

decreased incidence of tumors by chemical induction ( J:138529 )

• tumor development after treatment with both DMBA and TPA was significantly reduced in mice deficient in Stat3 expression as a result of tamoxifen treatment

• tamoxifen induced disruption of Stat3 inhibits growth of pre existing papillomas

integument

abnormal epidermal layer morphology ( J:138529 )

• reduced TPA induced epidermal proliferation after Stat3 disrutption mediated by tamoxifen

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:138529 )

• tumor development after treatment with both DMBA and TPA was significantly reduced in mice deficient in Stat3 expression as a result of tamoxifen treatment

• tamoxifen induced disruption of Stat3 inhibits growth of pre existing papillomas

Allelic Composition	Stat3^tm2Aki/Stat3^tm2Aki Tg(Alb1-cre)1Dlr/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3^tm2Aki mutation (1 available); any Stat3 mutation (72 available)
Tg(Alb1-cre)1Dlr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:109359 )

• insulin-induced inhibition of hepatic glucose production with a euglycemic clamp is attenuated

• inhibition of hepatic glucose production by ICV infusion of insulin is attenuated

Allelic Composition	Stat3^tm1Aki/Stat3^tm2Aki Tg(Col1a1-cre)1Kry/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal bone structure ( J:144906 )

• bone volume to tissue volume is reduced by half compared to controls

decreased trabecular bone thickness ( J:144906 )

• trabecular number and trabecular thickness are decreased in the tibia by about a third

• trabecular separation is increased by more than a third

abnormal bone ossification ( J:144906 )

• mineral apposition rate and bone formation rate are significantly reduced in these mice

Allelic Composition	Pdpk1^tm1Maka/Pdpk1^tm1Maka Stat3^tm2Aki/Stat3^tm2Aki Tg(Alb1-cre)1Dlr/0
Genetic Background	involves: 129S4/SvJae * 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpk1^tm1Maka mutation (0 available); any Pdpk1 mutation (138 available)
Stat3^tm2Aki mutation (1 available); any Stat3 mutation (72 available)
Tg(Alb1-cre)1Dlr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:109359 )

• insulin-induced inhibition of hepatic glucose production with a euglycemic clamp is attenuated even more than in single knockouts for either Stat3 or Pdk1

impaired glucose tolerance ( J:109359 )

• glucose tolerance is impaired further compared to conditional single Pdk1-null mice

Allelic Composition	Stat1^tm1Rds/Stat1^tm1Rds Stat3^tm2Aki/Stat3^tm2Aki Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Stat1^tm1Rds mutation (4 available); any Stat1 mutation (74 available)
Stat3^tm2Aki mutation (1 available); any Stat3 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

colitis ( J:83280 )

• mice develop chronic enterocolitis although it is not as severe as in Stat3 null mice

increased CD4-positive, alpha-beta T cell number ( J:83280 )

• splenic interferon-gamma producing CD4+ T cells are increased in mice treated with PMA and ionomycin but not a much as in Stat3 null mice

increased interferon-gamma secretion ( J:83280 )

• intestinal lamina propria CD4+ T cells produce more interferon-gamma than wild-type cells

increased interleukin-6 secretion ( J:83280 )

• macrophages produce more IL-6 than wild-type cells but less than Stat3 null cells

increased tumor necrosis factor secretion ( J:83280 )

• macrophages produce more TNF-alpha than wild-type cells but less than Stat3 null cells

digestive/alimentary system

abnormal colon morphology ( J:83280 )

• as early as 5 to 6 weeks, mice exhibit thickened colon walls with reduced glands compared to wild-type mice but unlike in Stat3 null mice not all regions of the colon are affected

colitis ( J:83280 )

• mice develop chronic enterocolitis although it is not as severe as in Stat3 null mice

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:83280 )

• splenic interferon-gamma producing CD4+ T cells are increased in mice treated with PMA and ionomycin but not a much as in Stat3 null mice

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