Analysis Tools
mortality/aging
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• die shortly after midgestation; no homozygotes survive to E18.5 and fewer homozygotes are recovered at E13.5
• prenatal lethality phenotype of homozygous mutant mice can be rescued by supplying them with noradrenergic agonists and these mice survive to around E18.5-birth
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• die shortly after midgestation; no homozygotes survive to E18.5 and fewer homozygotes are recovered at E13.5
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homeostasis/metabolism
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• lack noradrenaline synthesis
(J:55391)
• noradrenergic centers in the brain are absent in mutants that are supplied with noradrenergic agonist and survive to E18.5
(J:55391)
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nervous system
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• all autonomic ganglia fail to form properly and degenerate
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• absence of the enteric components of the autonomic nervous system at E13.5
• the foregut contingent of enteric nervous system degenerates by apoptosis between E10.5 and E13.5 and migration of enteric neural precursors towards the mid- and hindgut is arrested at the stomach
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• absence of parasympathetic ganglia at E13.5
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• absence of sympathetic ganglia at E13.5
• neural-crest derived sympathetic progenitors aggregate at the sites of sympathetic ganglion formation at E10.5, but subsequently fail to proliferate and/or degenerate
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• the area postrema never forms in mutants that are supplied with a noradrenergic agonist so that they can survive beyond E10.5
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• the central target of visceral sensory ganglia, the nucleus of the solitary tract, never forms in mutants that are supplied with a noradrenergic agonist so that they can survive beyond E10.5
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• locus coeruleus is absent in mutants that are supplied with noradrenergic agonist and survive to E18.5
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• exhibit defects in the differentiation of branchiomotor neurons in the rhombencephalon
(J:55391)
• visceral and branchial motor neurons are absent in the hindbrain of embryos supplied with a noradrenergic agonist so that they can survive to E18.5
(J:60832)
• precursors of branchial motor and visceral motor neurons arise in embryos but they fail to put out axons, to emigrate from the region and to differentiate
(J:60832)
• exhibit increased cell death of motor neuronal precursors
(J:60832)
• nucleus ambiguus is absent in mutants that are supplied with noradrenergic agonist and survive to E18.5
(J:60832)
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• the three cranial sensory ganglia that are part of the autonomic reflex circuits are atropic in mid-gestation embryos
(J:55391)
• the three epibranchial placode-derived visceral sensory ganglia (geniculate, petrosal, and nodose) degenerate
(J:86516)
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• the epibranchial placode-derived visceral sensory ganglia of the VIIth cranial nerve are atrophic in mid-gestation embryos
(J:55391)
• degenerates until visually absent by E16.5 in mutants that are supplied with a noradrenergic agonist so that they can survive beyond E10.5
(J:86516)
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• the epibranchial placode-derived visceral sensory ganglia of the IXth cranial nerves are atrophic in mid-gestation embryos
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• degenerates until visually absent by E16.5 in mutants that are supplied with a noradrenergic agonist so that they can survive beyond E10.5
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• the epibranchial placode-derived visceral sensory ganglia of the Xth cranial nerves are atrophic in mid-gestation embryos
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• degenerates until visually absent by E16.5 in mutants that are supplied with a noradrenergic agonist so that they can survive beyond E10.5
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• facial nerve (CN-VII) is absent in mutants that are supplied with a noradrenergic agonist and are able to survive to E18.5
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• trigeminal nerve (CN-V) is absent in mutants that are supplied with a noradrenergic agonist and are able survive to E18.5
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• the dorsal motor nucleus of the vagus nerve (CN-X) is absent in mutants that are supplied with a noradrenergic agonist and are able to survive to E18.5
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cardiovascular system
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• carotid body degenerates in mutants that are supplied with a noradrenergic agonist so that they can survive beyond E10.5
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• 3 of 8 embryos exhibit signs of vascular congestion around the time of death (about E13.5)
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