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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nf1tm2Tyj
targeted mutation 2, Tyler Jacks
MGI:1926954
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Nf1tm1Tyj/Nf1tm2Tyj chimera involves: 129S2/SvPas MGI:5313434


Genotype
MGI:5313434
ht1
Allelic
Composition		 Nf1tm1Tyj/Nf1tm2Tyj
Genetic
Background		 chimera involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Tyj mutation (3 available); any Nf1 mutation (161 available)
Nf1tm2Tyj mutation (0 available); any Nf1 mutation (161 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:58876 )
• mice exhibiting a high degree of chimerism are all dead by one month of age

muscle
abnormal muscle morphology ( J:58876 )
• mice exhibiting a moderate degree of chimerism exhibit muscle dysplasia

normal phenotype
no abnormal phenotype detected ( J:58876 )
• mice exhibiting a low degree of chimerism exhibit normal pathology

neoplasm
increased neurofibroma incidence ( J:58876 )
• mice exhibiting a moderate degree of chimerism exhibit an increased incidence of neurofibromas; plexiform neurofibromas only, no dermal neurofibromas

nervous system
increased neurofibroma incidence ( J:58876 )
• mice exhibiting a moderate degree of chimerism exhibit an increased incidence of neurofibromas; plexiform neurofibromas only, no dermal neurofibromas




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory