Phenotypes associated with this allele

• Allele Symbol: Nf2^tm2.1Gth
• Allele Name: targeted mutation 2.1, Gilles Thomas
• Allele ID: MGI:1926957
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nf2^tm2.1Gth/Nf2^tm2.1Gth	involves: 129P2/OlaHsd * FVB/N	MGI:2447475
ht2	Nf2^tm2.1Gth/Nf2^+	involves: 129P2/OlaHsd * FVB/N	MGI:2447474

Genotype
MGI:2447475

hm1

• Allelic Composition: Nf2^tm2.1Gth/Nf2^tm2.1Gth
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:63264 )

• mice die prior to E9.5

Genotype
MGI:2447474

ht2

• Allelic Composition: Nf2^tm2.1Gth/Nf2⁺
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

neoplasm

neoplasm ( J:63264 )

N • mice do not develop schwannoma, meningioma or other NF2 associated tumors

increased lung adenocarcinoma incidence ( J:63264 )

• in 14% in mice

increased fibrosarcoma incidence ( J:63264 )

• in 43% of mice with 1 of 3 metastasizing to the liver

increased osteosarcoma incidence ( J:63264 )

• in 43% of mice

increased osteoma incidence ( J:63264 )

• 29% of mice develop osteoma

respiratory system

increased lung adenocarcinoma incidence ( J:63264 )

• in 14% in mice

skeleton

increased osteosarcoma incidence ( J:63264 )

• in 43% of mice

increased osteoma incidence ( J:63264 )

• 29% of mice develop osteoma

nervous system

nervous system phenotype ( J:63264 )

N • mice exhibit normal Schwann cell proliferation