All Phenotypes Nkx3-1<tm1Mms> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nkx3-1^tm1Mms/Nkx3-1^tm1Mms	either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)	MGI:2175152
hm2	Nkx3-1^tm1Mms/Nkx3-1^tm1Mms	involves: 129S1/Sv	MGI:3811038
ht3	Nkx3-1^tm1Mms/Nkx3-1⁺	either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)	MGI:2175153
cx4	Nkx3-1^tm1Mms/Nkx3-1⁺ Pten^tm1Rps/Pten⁺	involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J	MGI:5569928
cx5	Nkx3-1^tm1Mms/Nkx3-1^tm1Mms Pten^tm1Rps/Pten⁺	involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J	MGI:5569926

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

reduced male mating frequency ( J:54465 )

• homozygotes are fertile; however, mutant males exhibit difficulties in forming copulatory plugs with advancing age

endocrine/exocrine glands

abnormal bulbourethral gland development ( J:54465 )

• adult homozygotes show a 15-fold reduction in mucin-producing cells and an 11-fold increase in ductal cells relative to wild-type mice

bulbourethral gland hypoplasia ( J:54465 )

• adult homozygotes show a significant reduction in BUG overall size and wet weight relative to wild-type mice, concomittant with a 15-fold loss of mucin cells

abnormal prostate gland anterior lobe morphology ( J:54465 )

• adult homozygotes often exhibit a transparent anterior prostate relative to the typically opaque wild-type gland

• as early as 4 weeks of age, the mutant anterior prostate displays a multilayered hyperplastic epithelium with relatively normal nuclear morphology

• by 12 weeks, the mutant anterior prostate epithelium exhibits dysplastic regions with variations in nuclear size and shape as well as loss of luminal space and secretory material

prostate gland anterior lobe hyperplasia ( J:54465 )

• at 1 year, the mutant anterior prostate shows extensive hyperplastic epithelium with severely dysplastic focal areas but no evidence of tumor formation

abnormal prostate gland branching morphogenesis ( J:54465 )

• adult homozygotes exhibit decreased ductal branching without an accompanying reduction in the number, overall size or wet weight of prostatic lobes

prostate gland dorsolateral lobe hyperplasia ( J:54465 )

• at 1 year, the mutant dorsolateral prostate shows mild hyperplasia and severe dysplasia

• however, the ventral prostate remains unaffected

decreased prostate gland duct number ( J:54465 )

• as early as P10-P11, homozygotes show a 60%-75% reduction in ductal tip number relative to wild-type mice

abnormal prostate gland epithelium morphology ( J:54465 )

• adult homozygotes exhibit prostate epithelial dysplasia which becomes increasingly severe with advancing age

• by 12 weeks of age, the mutant anterior prostate epithelium displays dysplastic areas with variation in nuclear size and shape as well as aberrant mitotic figures

• at 6 weeks, homozygotes exhibit a 5.8-fold increase in epithelial cell proliferation in the anterior prostate

prostate gland epithelial hyperplasia ( J:54465 )

• adult homozygotes exhibit prostate epithelial hyperplasia which becomes increasingly severe with advancing age

abnormal bulbourethral gland physiology ( J:54465 )

• adult homozygotes show altered secretory protein production, with a new protein species and reduced levels of wild-type secretory proteins

abnormal prostate gland physiology ( J:54465 )

• adult homozygotes show a significant reduction or loss of major prostatic secretory proteins, with a 2.6-fold decrease in total protein concentration of ventral prostate secretions

reproductive system

abnormal bulbourethral gland development ( J:54465 )

• adult homozygotes show a 15-fold reduction in mucin-producing cells and an 11-fold increase in ductal cells relative to wild-type mice

bulbourethral gland hypoplasia ( J:54465 )

• adult homozygotes show a significant reduction in BUG overall size and wet weight relative to wild-type mice, concomittant with a 15-fold loss of mucin cells

abnormal prostate gland anterior lobe morphology ( J:54465 )

• adult homozygotes often exhibit a transparent anterior prostate relative to the typically opaque wild-type gland

• as early as 4 weeks of age, the mutant anterior prostate displays a multilayered hyperplastic epithelium with relatively normal nuclear morphology

• by 12 weeks, the mutant anterior prostate epithelium exhibits dysplastic regions with variations in nuclear size and shape as well as loss of luminal space and secretory material

prostate gland anterior lobe hyperplasia ( J:54465 )

• at 1 year, the mutant anterior prostate shows extensive hyperplastic epithelium with severely dysplastic focal areas but no evidence of tumor formation

abnormal prostate gland branching morphogenesis ( J:54465 )

• adult homozygotes exhibit decreased ductal branching without an accompanying reduction in the number, overall size or wet weight of prostatic lobes

prostate gland dorsolateral lobe hyperplasia ( J:54465 )

• at 1 year, the mutant dorsolateral prostate shows mild hyperplasia and severe dysplasia

• however, the ventral prostate remains unaffected

decreased prostate gland duct number ( J:54465 )

• as early as P10-P11, homozygotes show a 60%-75% reduction in ductal tip number relative to wild-type mice

abnormal prostate gland epithelium morphology ( J:54465 )

• adult homozygotes exhibit prostate epithelial dysplasia which becomes increasingly severe with advancing age

• by 12 weeks of age, the mutant anterior prostate epithelium displays dysplastic areas with variation in nuclear size and shape as well as aberrant mitotic figures

• at 6 weeks, homozygotes exhibit a 5.8-fold increase in epithelial cell proliferation in the anterior prostate

prostate gland epithelial hyperplasia ( J:54465 )

• adult homozygotes exhibit prostate epithelial hyperplasia which becomes increasingly severe with advancing age

abnormal bulbourethral gland physiology ( J:54465 )

• adult homozygotes show altered secretory protein production, with a new protein species and reduced levels of wild-type secretory proteins

abnormal prostate gland physiology ( J:54465 )

• adult homozygotes show a significant reduction or loss of major prostatic secretory proteins, with a 2.6-fold decrease in total protein concentration of ventral prostate secretions

neoplasm

preneoplasia ( J:54465 )

• at 1 year, the mutant anterior prostate shows extensive epithelial hyperplasia and severe dysplasia along with a marked increase in proliferating cells, modeling a preneoplastic condition

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:54465

Allelic Composition	Nkx3-1^tm1Mms/Nkx3-1^tm1Mms
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx3-1^tm1Mms mutation (3 available); any Nkx3-1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:131932 )

• in lesions, basal cells are not disorganized in contrast to Tg(Pbsn-ERG*)1Vv mice at 12 weeks

reproductive system

reproductive system phenotype ( J:139640 )

N	• male mice exhibit normal testes

increased prostate intraepithelial neoplasia incidence ( J:131932 )

• in lesions, basal cells are not disorganized in contrast to Tg(Pbsn-ERG*)1Vv mice at 12 weeks

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:131932 )

• in lesions, basal cells are not disorganized in contrast to Tg(Pbsn-ERG*)1Vv mice at 12 weeks

Allelic Composition	Nkx3-1^tm1Mms/Nkx3-1⁺
Genetic Background	either: (involves: 129S1/Sv * 129S1/SvImJ) or (involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx3-1^tm1Mms mutation (3 available); any Nkx3-1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

prostate gland anterior lobe hyperplasia ( J:54465 )

• at 1 year, the anterior prostate of heterozygotes exhibits epithelial hyperplasia of reduced severity relative to homozygotes

abnormal prostate gland epithelium morphology ( J:54465 )

• at 1 year, the anterior prostate of heterozygotes exhibits epithelial dysplasia of reduced severity relative to homozygotes

• in addition, heterozygous dorsolateral prostates display a mild dysplasia relative to wild-type

prostate gland epithelial hyperplasia ( J:54465 )

• adult heterozygotes exhibit progressive prostate epithelial hyperplasia of reduced severity relative to homozygotes

abnormal prostate gland physiology ( J:54465 )

• at 6 weeks, heterozygotes exhibit a 4.5-fold increase in epithelial cell proliferation in the anterior prostate relative to wild-type mice

• adult heterozygotes show a significant reduction or loss of major secretory proteins in ventral prostate secretions

reproductive system

prostate gland anterior lobe hyperplasia ( J:54465 )

• at 1 year, the anterior prostate of heterozygotes exhibits epithelial hyperplasia of reduced severity relative to homozygotes

abnormal prostate gland epithelium morphology ( J:54465 )

• at 1 year, the anterior prostate of heterozygotes exhibits epithelial dysplasia of reduced severity relative to homozygotes

• in addition, heterozygous dorsolateral prostates display a mild dysplasia relative to wild-type

prostate gland epithelial hyperplasia ( J:54465 )

• adult heterozygotes exhibit progressive prostate epithelial hyperplasia of reduced severity relative to homozygotes

abnormal prostate gland physiology ( J:54465 )

• at 6 weeks, heterozygotes exhibit a 4.5-fold increase in epithelial cell proliferation in the anterior prostate relative to wild-type mice

• adult heterozygotes show a significant reduction or loss of major secretory proteins in ventral prostate secretions

neoplasm

preneoplasia ( J:54465 )

• at 1 year, the heterozygous anterior prostate shows epithelial hyperplasia and dysplasia along with a marked increase in proliferating cells, modeling a preneoplastic condition

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:54465

Allelic Composition	Nkx3-1^tm1Mms/Nkx3-1⁺ Pten^tm1Rps/Pten⁺
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx3-1^tm1Mms mutation (3 available); any Nkx3-1 mutation (38 available)
Pten^tm1Rps mutation (1 available); any Pten mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:75085 )

• early carcinoma lesions are seen in the prostate at 6 months of age

increased prostate intraepithelial neoplasia incidence ( J:75085 )

• at 6 months of age, high-grade prostatic intraepithelial neoplasia/early carcinoma lesions are seen in 36% of prostates, and by 12 months, all mice show lesions

• multifocal lesions in the prostate are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures

• lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index

• lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:75085 )

• early carcinoma lesions are seen in the prostate at 6 months of age

increased prostate intraepithelial neoplasia incidence ( J:75085 )

• at 6 months of age, high-grade prostatic intraepithelial neoplasia/early carcinoma lesions are seen in 36% of prostates, and by 12 months, all mice show lesions

• multifocal lesions in the prostate are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures

• lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index

• lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

reproductive system

increased prostate gland tumor incidence ( J:75085 )

• early carcinoma lesions are seen in the prostate at 6 months of age

increased prostate intraepithelial neoplasia incidence ( J:75085 )

• at 6 months of age, high-grade prostatic intraepithelial neoplasia/early carcinoma lesions are seen in 36% of prostates, and by 12 months, all mice show lesions

• multifocal lesions in the prostate are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures

• lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index

• lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:75085

Allelic Composition	Nkx3-1^tm1Mms/Nkx3-1^tm1Mms Pten^tm1Rps/Pten⁺
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:75085 )

• early carcinoma lesions are seen in the prostate at 6 months of age

increased prostate intraepithelial neoplasia incidence ( J:75085 )

• at 6 months of age, high-grade prostatic intraepithelial neoplasia /early carcinoma lesions are seen in 60% of prostates and by 10 months of age, all mice show lesions

• multifocal lesions are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures

• lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index

• lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:75085 )

• early carcinoma lesions are seen in the prostate at 6 months of age

increased prostate intraepithelial neoplasia incidence ( J:75085 )

• at 6 months of age, high-grade prostatic intraepithelial neoplasia /early carcinoma lesions are seen in 60% of prostates and by 10 months of age, all mice show lesions

• multifocal lesions are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures

• lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index

• lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

reproductive system

increased prostate gland tumor incidence ( J:75085 )

• early carcinoma lesions are seen in the prostate at 6 months of age

increased prostate intraepithelial neoplasia incidence ( J:75085 )

• at 6 months of age, high-grade prostatic intraepithelial neoplasia /early carcinoma lesions are seen in 60% of prostates and by 10 months of age, all mice show lesions

• multifocal lesions are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures

• lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index

• lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:75085

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