All Phenotypes Nrgn<tm1Kph> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nrgn^tm1Kph
targeted mutation 1, Kuo-Ping Huang
MGI:1927195

Summary

2 genotypes

Allelic Composition	Nrgn^tm1Kph/Nrgn^tm1Kph
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrgn^tm1Kph mutation (1 available); any Nrgn mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

impaired synaptic plasticity ( J:65166 )

• mice exhibit impaired short term plasticity and altered induction

abnormal long-term potentiation ( J:65166 )

• mice exhibit impaired long term potentiation (LTP) in the CA1 region and altered induction of LTP

behavior/neurological

abnormal spatial learning ( J:65166 )

• spatial learning impairment in Morris water maze test

Allelic Composition	Nrgn^tm1Kph/Nrgn⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrgn^tm1Kph mutation (1 available); any Nrgn mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

• mice exhibit impaired long term memory in contextual fear conditioning test

abnormal spatial learning ( J:65166 )

• spatial learning impairment in Morris water maze test although not as severely as homozygote

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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