All Phenotypes Cd74<tm1Doi> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd74^tm1Doi
targeted mutation 1, Christophe Benoist and Diane Mathis
MGI:1927205

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd74^tm1Doi/Cd74^tm1Doi	either: (involves: 129/Sv * B10.BR) or (involves: 129/Sv * C57BL/6)	MGI:2386165
hm2	Cd74^tm1Doi/Cd74^tm1Doi	involves: 129S2/SvPas	MGI:4355887
cx3	H2-DMa^tm1Luc/H2-DMa^tm1Luc Cd74^tm1Doi/Cd74^tm1Doi	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	MGI:2665538
cx4	Cd74^tm1Doi/Cd74^tm1Doi H2-DMa^tm1Doi/H2-DMa^tm1Doi	involves: 129S2/SvPas * C57BL/6	MGI:2386166
cx5	Cd74^tm1Doi/Cd74^tm1Doi Tap1^tm1Arp/Tap1^tm1Arp	involves: 129S2/SvPas * C57BL/6	MGI:3814823
cx6	Cd1d1^tm1.1Boes/Cd1d1^tm1.1Boes Cd74^tm1Doi/Cd74^tm1Doi	involves: 129S2/SvPas * C57BL/6	MGI:4355888

Allelic Composition	Cd74^tm1Doi/Cd74^tm1Doi
Genetic Background	either: (involves: 129/Sv * B10.BR) or (involves: 129/Sv * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Doi mutation (1 available); any Cd74 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:4119 , J:45185 )

• reduction in the CD4+CD8- cell population in the thymus and periphery (J:4119)

• reduced number of peripheral CD4+ T cells (J:45185)

increased CD8-positive, alpha-beta T cell number ( J:4119 )

• increase in CD4-CD8+ cell population in the thymus and periphery

abnormal antigen presentation ( J:4119 )

• antigen presenting cells (APCs) had defective proteine and peptide presentation

abnormal level of surface class II molecules ( J:45185 )

• abnormal level of surface class II molecules on B cells

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:4119 , J:45185 )

• reduction in the CD4+CD8- cell population in the thymus and periphery (J:4119)

• reduced number of peripheral CD4+ T cells (J:45185)

increased CD8-positive, alpha-beta T cell number ( J:4119 )

• increase in CD4-CD8+ cell population in the thymus and periphery

Allelic Composition	Cd74^tm1Doi/Cd74^tm1Doi
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Doi mutation (1 available); any Cd74 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal dendritic cell antigen presentation ( J:151699 )

• dendritic cells loaded with alphaGal-Cer are defective in activating wild-type Valpha14 invariant NKT cells

Allelic Composition	H2-DMa^tm1Luc/H2-DMa^tm1Luc Cd74^tm1Doi/Cd74^tm1Doi
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Doi mutation (1 available); any Cd74 mutation (36 available)
H2-DMa^tm1Luc mutation (1 available); any H2-DMa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal level of surface class II molecules ( J:45185 )

• reduced level of surface class II molecules on B cells

increased susceptibility to parasitic infection ( J:45185 )

• increased susceptibility to Leishmania major infection

Allelic Composition	Cd74^tm1Doi/Cd74^tm1Doi H2-DMa^tm1Doi/H2-DMa^tm1Doi
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Doi mutation (1 available); any Cd74 mutation (36 available)
H2-DMa^tm1Doi mutation (1 available); any H2-DMa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:42482 )

• significant mortality after a few weeks of age

growth/size/body

decreased body size ( J:42482 )

• showed runting

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:42482 )

• reduction in the CD4+CD8- cell population and a compensatory increase in CD4-CD8+ cell population

increased CD8-positive, alpha-beta T cell number ( J:42482 )

• compensatory increase in CD4-CD8+ cell population due to reduction in the CD4+CD8- cell population

immune system

decreased CD4-positive, alpha-beta T cell number ( J:42482 )

• reduction in the CD4+CD8- cell population and a compensatory increase in CD4-CD8+ cell population

increased CD8-positive, alpha-beta T cell number ( J:42482 )

• compensatory increase in CD4-CD8+ cell population due to reduction in the CD4+CD8- cell population

abnormal professional antigen presenting cell physiology ( J:42482 )

• antigen presenting cells (APCs) had defective protein and peptide presentation

Allelic Composition	Cd74^tm1Doi/Cd74^tm1Doi Tap1^tm1Arp/Tap1^tm1Arp
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Doi mutation (1 available); any Cd74 mutation (36 available)
Tap1^tm1Arp mutation (4 available); any Tap1 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell number ( J:113083 )

• numbers of typical (i.e. CD4⁺- or CD8⁺- T cells) are reduced

• T cells that express the canonical mVa19-Ja33 TCR rearrangement are 10-fold more abundant in the lamina propia of the gut compared to controls

immune system

abnormal T cell number ( J:113083 )

• numbers of typical (i.e. CD4⁺- or CD8⁺- T cells) are reduced

• T cells that express the canonical mVa19-Ja33 TCR rearrangement are 10-fold more abundant in the lamina propia of the gut compared to controls

Allelic Composition	Cd1d1^tm1.1Boes/Cd1d1^tm1.1Boes Cd74^tm1Doi/Cd74^tm1Doi
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1^tm1.1Boes mutation (0 available); any Cd1d1 mutation (35 available)
Cd74^tm1Doi mutation (1 available); any Cd74 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal dendritic cell antigen presentation ( J:151699 )

• dendritic cells loaded with alphaGal-Cer are defective in activating wild-type Valpha14 invariant NKT cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24