Analysis Tools|
Allele Symbol Allele Name Allele ID |
H2-Ab1b-tm1Doi targeted mutation 1, Christophe Benoist and Diane Mathis MGI:1927483 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decrease in hippocampal neurogenesis
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• decrease in hippocampal neurogenesis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• impaired breeding performance
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• peripheral CD4+ cells are larger in size than normal
• thymus CD4+ cells are cortical cells and smaller than normal in size
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• in spleen cells, a slight increase in the number of CD8+ T cells compared to wild-type is seen pre- and post-infection
(J:64283)
• proportional increase of CD8+ cell number in periphery
(J:65736)
• increased numbers in the thymus sometimes but not always
(J:65736)
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• CD4+ T cell population in the spleens are reduced 3-fold compared to Ciita-deficient mice and even more greatly reduced compared to wild-type
(J:51885)
• massive reduction of peripheral CD4+ cells to 3-7% normal numbers
(J:65736)
• moderate reduction of CD4+ cells in the thymus to 17-30% of normal
(J:65736)
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• in spleen cells, there is a 4.5-fold increase in the number of CD4+CD69 high cells in mutants at 8 weeks after parasite infection
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• reduced follicular zone at 13 weeks
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• absent but B cell differentiation not grossly disturbed
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• expanded at 13 weeks
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• very few CD4+ cells in the periarteriolar sheath of the spleen
• normal numbers of CD4+ cells in the B cell follicles
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• very few CD4+ cells in the paracortex of the lymph nodes
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• reduced numbers of cells expressing IgD at 10 weeks
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• 10-100 fold reduction in IgG1 levels in the serum
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• no T-cell dependent antigen responses
• double positive T cells express higher than normal levels of CD4
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• peripheral cells express reduced levels of CD4 and TCR AlphaBeta but high levels of CD44
• thymus CD4 single positive cells express very low but detectable levels of CD8
• higher than normal numbers in thymus express TCR AlphBeta but at lower levels
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• spleen and lymph node cells produced no measurable cytokines at 8 weeks after infection with parasite antigens
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• after infection with L. amazonensis, mice show no lesion development up to 11 weeks post infection, reduced cellular infiltration, lower parasite load and fewer cells in the popliteal lymph nodes draining the infected foots
• after infection with L. amazonensis, infected cells contained tightly packed organisms with few parasitophorous vacuole visible whereas infected macrophages in wild-type mice contained only a few organisms which are preferentially located at the edge of parasitophorous vacuoles
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• lesions become significantly larger with higher parasitic burdens 16 weeks after L. major infection, compared with lesion resolution in wild-type
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• in spleen cells, a slight increase in the number of CD8+ T cells compared to wild-type is seen pre- and post-infection
(J:64283)
• proportional increase of CD8+ cell number in periphery
(J:65736)
• increased numbers in the thymus sometimes but not always
(J:65736)
|
|
• CD4+ T cell population in the spleens are reduced 3-fold compared to Ciita-deficient mice and even more greatly reduced compared to wild-type
(J:51885)
• massive reduction of peripheral CD4+ cells to 3-7% normal numbers
(J:65736)
• moderate reduction of CD4+ cells in the thymus to 17-30% of normal
(J:65736)
|
|
• in spleen cells, there is a 4.5-fold increase in the number of CD4+CD69 high cells in mutants at 8 weeks after parasite infection
|
|
• reduced follicular zone at 13 weeks
|
|
• absent but B cell differentiation not grossly disturbed
|
|
• expanded at 13 weeks
|
|
• very few CD4+ cells in the periarteriolar sheath of the spleen
• normal numbers of CD4+ cells in the B cell follicles
|
|
• reduced numbers of cells expressing IgD at 10 weeks
|
|
• 10-100 fold reduction in IgG1 levels in the serum
|
|
• no T-cell dependent antigen responses
• double positive T cells express higher than normal levels of CD4
|
|
• peripheral cells express reduced levels of CD4 and TCR AlphaBeta but high levels of CD44
• thymus CD4 single positive cells express very low but detectable levels of CD8
• higher than normal numbers in thymus express TCR AlphBeta but at lower levels
|
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 10-11 week old mice of the fourth backcross generation to NOD/Lt mice are completely free of insulitis compared to NOD controls which develop insulitis by 6-8 weeks
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• 10-11 week old mice of the fourth backcross generation to NOD/Lt mice are completely free of insulitis compared to NOD controls which develop insulitis by 6-8 weeks
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• pathological inflammatory phenotype of Lattm1Mal homozygotes is absent in these mice
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• in both the thymus and spleen
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• in both the thymus and spleen
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• in both the thymus and spleen
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• in both the thymus and spleen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decrease in hippocampal neurogenesis
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• decrease in hippocampal neurogenesis
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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