All Phenotypes Cd74<tm1Liz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd74^tm1Liz
targeted mutation 1, Elizabeth K Bikoff
MGI:1927530

Summary

15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd74^tm1Liz/Cd74^tm1Liz	B6.129S-Cd74^tm1Liz	MGI:3688838
hm2	Cd74^tm1Liz/Cd74^tm1Liz	B6.129S-Cd74^tm1Liz/J	MGI:5491939
hm3	Cd74^tm1Liz/Cd74^tm1Liz	involves: 129S/SvEv	MGI:3760861
hm4	Cd74^tm1Liz/Cd74^tm1Liz	involves: 129S/SvEv * BALB/cAn	MGI:3689073
hm5	Cd74^tm1Liz/Cd74^tm1Liz	involves: 129S/SvEv * BALB/c * C57BL	MGI:3689074
hm6	Cd74^tm1Liz/Cd74^tm1Liz	involves: 129S/SvEv * C57BL/6	MGI:3689001
hm7	Cd74^tm1Liz/Cd74^tm1Liz	involves: 129S/SvEv * C57BL/6J	MGI:3688756
hm8	Cd74^tm1Liz/Cd74^tm1Liz	involves: 129S/SvEv * C57BL * C57BL/10 * C57BR	MGI:3689075
ht9	Cd74^tm1Liz/Cd74⁺	involves: 129S/SvEv	MGI:4421700
ht10	Cd74^tm2Liz/Cd74^tm1Liz	involves: 129S/SvEv * C57BL/6	MGI:3688837
cx11	Cd74^tm1Liz/Cd74^tm1Liz Sppl2a^tm1Basc/Sppl2a^tm1Basc	B6.129-Sppl2a^tm1Basc Cd74^tm1Liz	MGI:5491938
cx12	Cd74^tm1Liz/Cd74^tm1Liz Sppl2a^tm1Dgen/Sppl2a^tm1Dgen	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	MGI:5484587
cx13	Cd74^tm1Liz/Cd74^tm1Liz H2-DMa^tm1Luc/H2-DMa^tm1Luc Tg(CD74)AR194Ayr/?	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J	MGI:3760430
cx14	Cd74^tm1Liz/Cd74^tm1Liz H2-DMa^tm1Luc/H2-DMa^tm1Luc Tg(CD74*)1Ayr/0	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J	MGI:3839583
cx15	Cd74^tm1Liz/Cd74^tm1Liz H2-DMa^tm1Liz/H2-DMa^tm1Liz	involves: 129S/SvEv * BALB/c	MGI:3689121

Allelic Composition	Cd74^tm1Liz/Cd74^tm1Liz
Genetic Background	B6.129S-Cd74^tm1Liz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Liz mutation (4 available); any Cd74 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:28966 )

• lymph node cells show significantly lower proliferative responses to immunization with keyhole limpet cyanin (KLH) compared to wild-type

decreased CD4-positive, alpha-beta T cell number ( J:28966 )

• significant reduction in numbers of mature CD4+CD8- thymocytes in thymus and periphery is seen compared to wild-type

abnormal T-helper 1 physiology ( J:125654 )

• in vivo, Th1 response to MOG is absent unlike in wild-type mice

• in vitro, lymph node cells from mice receiving wild-type MOG T cells exhibit reduced Th1 recall response compared with similarly treated wild-type mice

• in vivo, Th1 response to PLP is reduced compared to in wild-type mice

• in vitro, the frequency of Th1 recall response is greater than in H2-Dma^tm1Luc homozygotes

decreased susceptibility to type IV hypersensitivity reaction ( J:125654 )

• dramatically compared to in wild-type mice when wild-type MOG T cells are transferred

abnormal antigen presentation ( J:125654 )

• antigen presenting cells cannot process and present recombinant MOG protein unlike wild-type cells

abnormal antigen presentation via MHC class II ( J:28966 )

• class II molecules are relatively ineffective for presentation of native protein antigens

abnormal level of surface class II molecules ( J:28966 )

• mutants expressed greatly reduced amounts of class II on spleen cells compared to wild-type

defective assembly of class II molecules ( J:28966 )

• in spleen cells, immature alpha and beta chains exhibiting no evidence of having been exported past the cis-Golgi are observed, whereas compact alpha/beta dimers efficiently transported past the cis-Golgi are produced by Cd74^tm2Liz-deficient cells; floppy conformers are seen, compared to compact dimers in wild-type

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:125654 )

• whether MOG-primed or adoptively transferred with MOG-specific T blasts, mice fail to develop symptoms of experimental autoimmune encephalomyelitis (EAE) unlike wild-type mice

• PLP-treated mice fail to develop EAE unlike similarly treated wild-type mice

hematopoietic system

decreased T cell proliferation ( J:28966 )

• lymph node cells show significantly lower proliferative responses to immunization with keyhole limpet cyanin (KLH) compared to wild-type

decreased CD4-positive, alpha-beta T cell number ( J:28966 )

• significant reduction in numbers of mature CD4+CD8- thymocytes in thymus and periphery is seen compared to wild-type

abnormal T-helper 1 physiology ( J:125654 )

• in vivo, Th1 response to MOG is absent unlike in wild-type mice

• in vitro, lymph node cells from mice receiving wild-type MOG T cells exhibit reduced Th1 recall response compared with similarly treated wild-type mice

• in vivo, Th1 response to PLP is reduced compared to in wild-type mice

• in vitro, the frequency of Th1 recall response is greater than in H2-Dma^tm1Luc homozygotes

cellular

decreased T cell proliferation ( J:28966 )

• lymph node cells show significantly lower proliferative responses to immunization with keyhole limpet cyanin (KLH) compared to wild-type

Allelic Composition	Cd74^tm1Liz/Cd74^tm1Liz
Genetic Background	B6.129S-Cd74^tm1Liz/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Liz mutation (4 available); any Cd74 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell number ( J:194664 )

• in the spleen and lymph node

hematopoietic system

decreased B cell number ( J:194664 )

• in the spleen and lymph node

Allelic Composition	Cd74^tm1Liz/Cd74^tm1Liz
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Liz mutation (4 available); any Cd74 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:155870 )

N	• no evidence for anemia or thrombocytopenia

abnormal positive T cell selection ( J:125548 )

• CD4+ T cell-selection is almost completely abrogated in lethally irradiated hosts upon transfer of transgenic bone marrow

immune system

abnormal positive T cell selection ( J:125548 )

• CD4+ T cell-selection is almost completely abrogated in lethally irradiated hosts upon transfer of transgenic bone marrow

Allelic Composition	Cd74^tm1Liz/Cd74^tm1Liz
Genetic Background	involves: 129S/SvEv * BALB/cAn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Liz mutation (4 available); any Cd74 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:110927 )

• B cell maturation is defective

increased immature B cell number ( J:110927 )

• higher percentages of immature B cells lacking surface IgD and CD23 expression

decreased CD4-positive, alpha-beta T cell number ( J:110927 , J:113714 )

• mutant thymi display 3-fold fewer mature CD4+ T cells compared to wild-type; spleen and lymph node CD4+ T cell percentages are reduced ~2-fold (J:110927)

• T cells carrying Vbeta (VB) segments (VB3, 5, 11 and 12) are well represented whereas they are completely eliminated in wild-type BALB/c controls, suggesting a role during presentation of endogenous superantigens (J:113714)

abnormal professional antigen presenting cell physiology ( J:113714 )

• splenocytes display enhanced binding capabilities

abnormal dendritic cell antigen presentation ( J:110927 )

• dendritic cells show reduced class II surface expression in overnight culture compared to wild-type

abnormal antigen presentation via MHC class II ( J:110927 , J:113714 )

• mutant spleen cells on an H-2^d background show enhanced peptide-loading capabilities over wild-type cells (J:110927)

• T cell hybridomas produce Il-2 and T cell lines proliferate when stimulated by mutant spleen cells; similar results are seen using T cell clones specific for peptides including ovalbumin (OVA)_323-339 and IgG2a^b (J:110927)

• spleen cells are ineffective for presentation of intact protein antigen as opposed to processed peptide antigens (J:110927)

• spleen cells effectively function as stimulators for allogeneic T cells, eliciting strong mixed lymphocyte responses (J:110927)

• antigen presentation by mutant spleen cells to E^drestricted T cell clones is substantially decreased (J:113714)

• E^drestricted T cells show enhanced activity when challenged with endogenously process beta 2 microglobulin (B2m) epitopes in presence of mutant splenocytes (J:113714)

hematopoietic system

abnormal B cell differentiation ( J:110927 )

• B cell maturation is defective

increased immature B cell number ( J:110927 )

• higher percentages of immature B cells lacking surface IgD and CD23 expression

decreased CD4-positive, alpha-beta T cell number ( J:110927 , J:113714 )

• mutant thymi display 3-fold fewer mature CD4+ T cells compared to wild-type; spleen and lymph node CD4+ T cell percentages are reduced ~2-fold (J:110927)

Allelic Composition	Cd74^tm1Liz/Cd74^tm1Liz
Genetic Background	involves: 129S/SvEv * BALB/c * C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Liz mutation (4 available); any Cd74 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell proliferation ( J:110927 )

• proliferative responses to intact hen egg lysozyme (HEL) protein antigen are reduced in mutants, but immunized mice challenged secondarily with HEL_46-61 peptide show similar response to wild-type mice

abnormal B cell differentiation ( J:110927 )

• B cell maturation is defective

increased immature B cell number ( J:110927 )

• higher percentages of immature B cells lacking surface IgD and CD23 expression

abnormal dendritic cell antigen presentation ( J:110927 )

• dendritic cells show reduced class II surface expression in overnight culture compared to wild-type

abnormal antigen presentation via MHC class II ( J:110927 )

• spleen cells effectively function as stimulators for allogeneic T cells, eliciting strong mixed lymphocyte responses

hematopoietic system

abnormal T cell proliferation ( J:110927 )

abnormal B cell differentiation ( J:110927 )

• B cell maturation is defective

increased immature B cell number ( J:110927 )

• higher percentages of immature B cells lacking surface IgD and CD23 expression

cellular

abnormal T cell proliferation ( J:110927 )

Allelic Composition	Cd74^tm1Liz/Cd74^tm1Liz
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Liz mutation (4 available); any Cd74 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal antigen presentation via MHC class II ( J:111565 )

• mutants display isotype-specific antigen presentation defects; MHC A^k-restricted antigen presentation is reduced compared to wild-type

Allelic Composition	Cd74^tm1Liz/Cd74^tm1Liz
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Liz mutation (4 available); any Cd74 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:65918 )

• homozygotes are usually smaller than littermates

cachexia ( J:65918 )

• occasionally, homozygotes display symptoms of severe wasting

hematopoietic system

decreased T cell proliferation ( J:72243 )

• immunization with p35-55 does not induce significant T cell proliferation compared to wild-type cells

decreased CD4-positive, alpha-beta T cell number ( J:65918 )

• mutants have decreased numbers of CD4+8- TCRhi T cells in the thymus

• number of CD4+CD8- T cells in the periphery; decreased numbers of mature CD4+ T lymphocytes are seen in analyses of splenic T cells

immune system

decreased T cell proliferation ( J:72243 )

• immunization with p35-55 does not induce significant T cell proliferation compared to wild-type cells

decreased CD4-positive, alpha-beta T cell number ( J:65918 )

• mutants have decreased numbers of CD4+8- TCRhi T cells in the thymus

• number of CD4+CD8- T cells in the periphery; decreased numbers of mature CD4+ T lymphocytes are seen in analyses of splenic T cells

abnormal antigen presentation ( J:72243 )

• splenic antigen presenting cells (APCs) present an encephalitogenic MOG peptide p35-55 to I-A^b-restricted p35-55-specific T cells equivalently to wild-type APCs, stimulating proliferation but are ineffective at presenting intact MOG to T cells compared with wild-type APCs, suggesting that processing is required for presentation of intact MOG

abnormal antigen presentation via MHC class II ( J:65918 )

• mutant spleen cells stimulated stronger responses in presence of already processed peptides hen egg lysozyme (HEL) 74-88 and Ealpha 52-68, but fail to present native protein antigens keyhole limpet cyanin (KLH) and IgG2a

abnormal level of surface class II molecules ( J:65918 )

• mutant spleen cells exhibit reduced levels of I-A^b surface antigen compared to wild-type spleen cells

defective assembly of class II molecules ( J:65918 )

• mutant spleen cells show significantly reduced amounts of alpha/beta heterodimers associated with the invariant chain; increased amounts of free alpha and beta chains are present

• majority of class II molecules are comprised of immature alpha and beta chains that have not been exported past the cis-Golgi

• no mature compact SDS-resistant alpha/beta heterodimers (I-A^b) are produced by mutant spleens in contrast to wild-type cells

• class II molecules produced by mutants show enhanced peptide binding compared to wild-type; molecules behave as if empty or occupied by easily displaced peptide in contrast to wild-type cells that are stably occupied with self and serum-derived peptides

decreased interferon-gamma secretion ( J:72243 )

• immunization with p35-55 does not induce Ifng secretion indicating inability to prime p35-55 specific CD4+ T cells

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:72243 )

• mice do not develop experimental autoimmune encephalitis (EAE) upon direct immunization with p35-55 while wild-type mice do develop EAE

• adoptive transfer of wild-type encephalitogenic T cells does not induce EAE in mutant recipients

cellular

decreased T cell proliferation ( J:72243 )

• immunization with p35-55 does not induce significant T cell proliferation compared to wild-type cells

Allelic Composition	Cd74^tm1Liz/Cd74^tm1Liz
Genetic Background	involves: 129S/SvEv * C57BL * C57BL/10 * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Liz mutation (4 available); any Cd74 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell proliferation ( J:110927 )

• proliferative responses to intact protein antigens are reduced in mutants, but immunized mice challenged secondarily with OVA_323-339 peptide show similar response to wild-type mice

abnormal B cell differentiation ( J:110927 )

• B cell maturation is defective

increased immature B cell number ( J:110927 )

• higher percentages of immature B cells lacking surface IgD and CD23 expression

abnormal dendritic cell antigen presentation ( J:110927 )

• dendritic cells show reduced class II surface expression in overnight culture compared to wild-type

abnormal antigen presentation via MHC class II ( J:110927 )

• spleen cells from mice with an H-2^k haplotype background effectively function as stimulators for allogeneic T cells, eliciting strong mixed lymphocyte responses

hematopoietic system

abnormal T cell proliferation ( J:110927 )

• proliferative responses to intact protein antigens are reduced in mutants, but immunized mice challenged secondarily with OVA_323-339 peptide show similar response to wild-type mice

abnormal B cell differentiation ( J:110927 )

• B cell maturation is defective

increased immature B cell number ( J:110927 )

• higher percentages of immature B cells lacking surface IgD and CD23 expression

cellular

abnormal T cell proliferation ( J:110927 )

• proliferative responses to intact protein antigens are reduced in mutants, but immunized mice challenged secondarily with OVA_323-339 peptide show similar response to wild-type mice

Allelic Composition	Cd74^tm1Liz/Cd74⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Liz mutation (4 available); any Cd74 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:155870 )

N	• no evidence for anemia or thrombocytopenia

Allelic Composition	Cd74^tm2Liz/Cd74^tm1Liz
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Liz mutation (4 available); any Cd74 mutation (36 available)
Cd74^tm2Liz mutation (1 available); any Cd74 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:28966 )

N	• compact Aalpha^bAbeta^b dimers are produced efficiently in absence of invariant chain p41 isoform • mutants show no significant differences in level of class II expressed on spleen cells compared to wild-type • normal numbers of CD4+CD8- T cells are observed compared to Cd74^tm1Liz

increased T cell proliferation ( J:28966 )

• lymph node cells show equivalent proliferative responses to KLH immunization compared to those from heterozygous littermates, but greater than wild-type cells

abnormal antigen presentation via MHC class II ( J:28966 )

• cell expressing the p31 invariant chain (lacking p41 chain) can present native protein antigens including keyhole limpet cyanin (KLH), ovalbumin (OVA), and IgG2a^a compared to complete invariant chain deficient spleen cells

hematopoietic system

increased T cell proliferation ( J:28966 )

• lymph node cells show equivalent proliferative responses to KLH immunization compared to those from heterozygous littermates, but greater than wild-type cells

cellular

increased T cell proliferation ( J:28966 )

• lymph node cells show equivalent proliferative responses to KLH immunization compared to those from heterozygous littermates, but greater than wild-type cells

Allelic Composition	Cd74^tm1Liz/Cd74^tm1Liz Sppl2a^tm1Basc/Sppl2a^tm1Basc
Genetic Background	B6.129-Sppl2a^tm1Basc Cd74^tm1Liz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Liz mutation (4 available); any Cd74 mutation (36 available)
Sppl2a^tm1Basc mutation (0 available); any Sppl2a mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Sppl2a^tm1Basc/Sppl2a^tm1Basc Cd74^tm1Liz/Cd74^tm1Liz B cells show normal morphology compared to the increased vacuoles in Sppl2a^tm1Basc/Sppl2a^tm1Basc B cells

immune system

immune system phenotype ( J:194664 )

N	• B cells exhibit the same number of vacuoles per cells as wild-type mice and Cd74^tm1Liz homozygotes • calcium ion flux in T1 B cells is restored to normal • B cell maturation and function are restored • the size of Peyer's patches is restored

decreased B cell number ( J:194664 )

• compared with wild-type mice but improved from Sppl2a^tm1Basc homozygotes in the spleen and lymph nodes

decreased Peyer's patch number ( J:194664 )

• compared with wild-type mice but improved from Sppl2a^tm1Basc homozygotes

hematopoietic system

decreased B cell number ( J:194664 )

• compared with wild-type mice but improved from Sppl2a^tm1Basc homozygotes in the spleen and lymph nodes

Allelic Composition	Cd74^tm1Liz/Cd74^tm1Liz Sppl2a^tm1Dgen/Sppl2a^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Liz mutation (4 available); any Cd74 mutation (36 available)
Sppl2a^tm1Dgen mutation (0 available); any Sppl2a mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:194595 )

N	• mice exhibit normalized numbers of T2 B cells, marginal zone B cells and myeloid dendritic cells

decreased follicular B cell number ( J:194595 )

hematopoietic system

decreased follicular B cell number ( J:194595 )

Allelic Composition	Cd74^tm1Liz/Cd74^tm1Liz H2-DMa^tm1Luc/H2-DMa^tm1Luc Tg(CD74)AR194Ayr/?
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Liz mutation (4 available); any Cd74 mutation (36 available)
H2-DMa^tm1Luc mutation (1 available); any H2-DMa mutation (27 available)
Tg(CD74)AR194Ayr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:88717 )

• the number of CD4+ T cells is reduced to levels below wild-type but similar to those observed in Cd74^tm1Liz H2-DMa^tm1Luc homozygotes

abnormal antigen presentation via MHC class II ( J:88717 )

• unlike in wild-type cells, splenocytes are unable to elicit presentation of MHC class II exogenous antigens or of two endogenous antigens (IgM and beta-2 microglobulin)

• however, Tg(CD74)AR194Ayr completely rescues the MHC class II peptide loading observed in Cd74^tm1Liz H2-DMa^tm1Luc homozygotes and presentation of endogenous antigens for CD22 is normal

• after incubation with Ealpha peptide, loading of MHC class II is less than on similarly treated Cd74^tm1Liz H2-DMa^tm1Luc Tg(CD74*)AR194Ayr splenocytes

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:88717 )

• the number of CD4+ T cells is reduced to levels below wild-type but similar to those observed in Cd74^tm1Liz H2-DMa^tm1Luc homozygotes

Allelic Composition	Cd74^tm1Liz/Cd74^tm1Liz H2-DMa^tm1Luc/H2-DMa^tm1Luc Tg(CD74*)1Ayr/0
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:88717 )

• the number of CD4+ T cells is rescued to 60% of normal

abnormal antigen presentation via MHC class II ( J:88717 )

• Tg(CD74)AR194Ayr partially rescues the MHC class II peptide loading observed in Cd74^tm1Liz H2-DMa^tm1Luc homozygotes

• after incubation with Ealpha peptide, loading of MHC class II is greater than on similarly treated Cd74^tm1Liz H2-DMa^tm1Luc Tg(CD74)AR194Ayr splenocytes

• splenocytes elicit greater antigen presentations than in Cd74^tm1Liz H2-DMa^tm1Luc Tg(CD74)AR194Ayr splenocytes

• splenocytes elicit presentation of exogenous protein antigens derived from one but not two antigen

• splenocyte presentaton of IgM and beta-2 microglobulin epitpes is less efficient than in Cd74^tm1Liz Tg(CD74)AR194Ayr or Cd74^tm1Liz Tg(CD74*)AR194Ayr mice

• however, splenocytes can elicit presentation from two endogenous protein antigens (IgM and beta-2 microglobulin)

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:88717 )

• the number of CD4+ T cells is rescued to 60% of normal

Allelic Composition	Cd74^tm1Liz/Cd74^tm1Liz H2-DMa^tm1Liz/H2-DMa^tm1Liz
Genetic Background	involves: 129S/SvEv * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Liz mutation (4 available); any Cd74 mutation (36 available)
H2-DMa^tm1Liz mutation (0 available); any H2-DMa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:113714 )

• double mutants display significant defects in CD4+ T cell development; numbers of CD4+ T cells in the thymus and periphery are greatly reduced compared to wild-type

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:113714 )

• double mutants display significant defects in CD4+ T cell development; numbers of CD4+ T cells in the thymus and periphery are greatly reduced compared to wild-type

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