Phenotypes associated with this allele

• Allele Symbol: Cd74^tm1Eae
• Allele Name: targeted mutation 1, Eileen A Elliott
• Allele ID: MGI:1927544
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd74^tm1Eae/Cd74^tm1Eae	B6.129S2-Cd74^tm1Eae	MGI:4867046
hm2	Cd74^tm1Eae/Cd74^tm1Eae	involves: 129S2/SvPas	MGI:3842543
hm3	Cd74^tm1Eae/Cd74^tm1Eae	involves: 129S2/SvPas * C57BL/6	MGI:6705078

Genotype
MGI:4867046

hm1

• Allelic Composition: Cd74^tm1Eae/Cd74^tm1Eae
• Genetic Background: B6.129S2-Cd74^tm1Eae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

arrested B cell differentiation ( J:112084 )

• arrest at the immature B cell stage

abnormal lymph node cell ratio ( J:112084 )

• striking decrease in the proportion of B cells in the lymph nodes

hematopoietic system

arrested B cell differentiation ( J:112084 )

• arrest at the immature B cell stage

Genotype
MGI:3842543

hm2

• Allelic Composition: Cd74^tm1Eae/Cd74^tm1Eae
• Genetic Background: involves: 129S2/SvPas

immune system

decreased B cell proliferation ( J:113050 , J:132865 )

• B cell proliferation in response to NP-Ficoll and NP-CGG is decreased compared to in wild-type cells (J:113050)

• following anti-CD74 stimulation (J:132865)

decreased CD4-positive, alpha-beta T cell number ( J:113050 )

decreased IgM level ( J:113050 )

• in response to NP immunization

abnormal level of surface class II molecules ( J:65917 )

• cell surface expression of class II molecules in splenocytes is decreased compared to in wild-type cells

cellular

decreased cell proliferation ( J:147772 )

• mouse embryonic fibroblasts transformed retrovirally with Ras produce fewer and smaller colonies than similarly treated wild-type cells

decreased B cell proliferation ( J:113050 , J:132865 )

• B cell proliferation in response to NP-Ficoll and NP-CGG is decreased compared to in wild-type cells (J:113050)

• following anti-CD74 stimulation (J:132865)

hematopoietic system

decreased B cell proliferation ( J:113050 , J:132865 )

• B cell proliferation in response to NP-Ficoll and NP-CGG is decreased compared to in wild-type cells (J:113050)

• following anti-CD74 stimulation (J:132865)

decreased CD4-positive, alpha-beta T cell number ( J:113050 )

decreased IgM level ( J:113050 )

• in response to NP immunization

Genotype
MGI:6705078

hm3

• Allelic Composition: Cd74^tm1Eae/Cd74^tm1Eae
• Genetic Background: involves: 129S2/SvPas * C57BL/6

cardiovascular system

increased susceptibility to myocardial ischemic injury ( J:213776 )

• left ventricle contractile dysfunction is more pronounced and myocardial necrosis is 2-fold more pronounced in isolated perfused hearts during reperfusion after ischemia than in homozygous Mif^tm1Dvd or wild-type hearts

increased myocardial infarct size ( J:213776 )

• infract size is greater in isolated perfused hearts during reperfusion after ischemia than in homozygous Mif^tm1Dvd or wild-type hearts

homeostasis/metabolism

increased susceptibility to myocardial ischemic injury ( J:213776 )

• left ventricle contractile dysfunction is more pronounced and myocardial necrosis is 2-fold more pronounced in isolated perfused hearts during reperfusion after ischemia than in homozygous Mif^tm1Dvd or wild-type hearts

increased myocardial infarct size ( J:213776 )

• infract size is greater in isolated perfused hearts during reperfusion after ischemia than in homozygous Mif^tm1Dvd or wild-type hearts