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Allele Symbol Allele Name Allele ID |
Ntn1Gt(ST629)Byg gene trap ST629, BayGenomics MGI:1927548 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no trochlear nerve abnormalities are detected at E11.5 and diaphragm innervation is similar to wild-type at E18.5
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| N |
• mice exhibit normal inner ear formation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no changes in apoptosis in the cervical spinal cord, brainstem or other regions of the nervous system are observed compared to wild-type
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• terminal end buds of mammary gland explants are abnormal with detached cap cells and increased subcapsular space
• detached cap cell are often found in the subcapsular space and breaks are seen in the basal lamina
• terminal end buds at the leading edge of the array are most severely affected
• a 17-fold increase in apoptosis is seen in detached cap cells
• growth of explants is slower compared to wild-type
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• terminal end buds of mammary gland explants are abnormal with detached cap cells and increased subcapsular space
• detached cap cell are often found in the subcapsular space and breaks are seen in the basal lamina
• terminal end buds at the leading edge of the array are most severely affected
• a 17-fold increase in apoptosis is seen in detached cap cells
• growth of explants is slower compared to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced pyramidal decussation
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• aberrant corticospinal tract axonal migrations
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• abnormal dorsal funiculus of the spinal cord
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• within a few days of birth
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• failure to suckle, milk never found in stomach
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• newborns unable to move forelimbs indepently, results in a paddling effect
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• abnormal trajectory of commissural axons; however, normal trajectory of motor neurons and trochlear axons
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• absent pontine nuclei
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike Lrig3Gt(LST016)Byg homozygotes, mice exhibit normal inner ear formation
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| N |
• unlike Lrig3Gt(LST016)Byg homozygotes, mice do not exhibit circling
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• severe defects in adhesion are seen in the mammary gland ducts
• in culture myoepithelial cells are impaired in their ability to adhere to luminal epithelial cells
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• end buds formed by transplanted mammary analage display subcapsular space, dissociated cap cells, cap cell layers devoid of underlying luminal epithelial cells, regions of disrupted cap cells, and regions of invaginated cap cell layers
• breaks in the basal lamina are seen and severe adhesion defects are detected
• between the luminal epithelial cells and the myoepithelial cells
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• end buds formed by transplanted mammary analage display subcapsular space, dissociated cap cells, cap cell layers devoid of underlying luminal epithelial cells, regions of disrupted cap cells, and regions of invaginated cap cell layers
• breaks in the basal lamina are seen and severe adhesion defects are detected
• between the luminal epithelial cells and the myoepithelial cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E11 the majority of En1 expressing neuron ventrally projecting axons are either truncated or turn rostrally before reaching the ventrolateral funiculus
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• at E11 the majority of En1 expressing neuron ventrally projecting axons are either truncated or turn rostrally before reaching the ventrolateral funiculus
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• at E11 the majority of En1 expressing neuron ventrally projecting axons are either truncated or turn rostrally before reaching the ventrolateral funiculus
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• at E11 the majority of En1 expressing neuron ventrally projecting axons are either truncated or turn rostrally before reaching the ventrolateral funiculus
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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