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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Myf6tm1Thbr
targeted mutation 1, Thomas Braun
MGI:1927607
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Myf6tm1Thbr/Myf6tm1Thbr either: (involves: 129S4/SvJae-Myf6tm1Thbr) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) MGI:2175129
cx2
Myf5tm1Jae/Myf5+
Myf6tm1Thbr/Myf6+
involves: 129S4/SvJae MGI:3714395


Genotype
MGI:2175129
hm1
Allelic
Composition
Myf6tm1Thbr/Myf6tm1Thbr
Genetic
Background
either: (involves: 129S4/SvJae-Myf6tm1Thbr) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf6tm1Thbr mutation (0 available); any Myf6 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within a few minutes after birth

embryo
• embryos show a lack of primary myocytes in somites between E9.5 and E10.5

skeleton
• lack the distal parts of the ribs and thus no contacts with the sternum are made
• lack the distal parts of the ribs (J:24360)
• ribs are shorter than in wild-type but are somewhat longer than in Myf5tm1Jae mice (J:31636)
• sternum is completely ossified

muscle
• significant decrease in muscle fibers of the deep axial muscles at several locations along the rostro-caudal axis (the deep back muscles)




Genotype
MGI:3714395
cx2
Allelic
Composition
Myf5tm1Jae/Myf5+
Myf6tm1Thbr/Myf6+
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1Jae mutation (1 available); any Myf5 mutation (17 available)
Myf6tm1Thbr mutation (0 available); any Myf6 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• double heterozygous mice that carry the Myf5 and Myf6 alleles on different chromosomes and express drastically reduced levels of Myf5 mRNA do not survive to weaning and when delivered by cesarean section at E18.5, the pups die within a few minutes after delivery

skeleton
• mutants lack the distal parts of the ribs
• the average rib length is between that of Myf6 and Myf5 homozygotes





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory