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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm1Wahl
targeted mutation 1, Geoffrey M Wahl
MGI:1927802
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm1Wahl/Trp53tm1Wahl involves: 129S4/SvJae MGI:3624330
hm2
 		Trp53tm1Wahl/Trp53tm1Wahl involves: C57BL/6 MGI:3625173
cx3
 		Mdm2tm1Glo/Mdm2+
Mdm4Gt(VICTR20)7Lex/Mdm4+
Trp53tm1Wahl/Trp53tm1Wahl 		involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6 MGI:3625182
cx4
 		Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Trp53tm1Wahl/Trp53tm1Wahl 		involves: 129S5/SvEvBrd * C57BL/6 MGI:3625172
cx5
 		Mdm4Gt(VICTR20)7Lex/Mdm4+
Trp53tm1Wahl/Trp53tm1Wahl 		involves: 129S5/SvEvBrd * C57BL/6 MGI:3625181
cx6
 		Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm1Wahl/Trp53tm1Wahl 		involves: 129S7/SvEvBrd * C57BL/6 MGI:3625170
cx7
 		Mdm2tm1Glo/Mdm2+
Trp53tm1Wahl/Trp53tm1Wahl 		involves: 129S7/SvEvBrd * C57BL/6 MGI:3625179


Genotype
MGI:3624330
hm1
Allelic
Composition		 Trp53tm1Wahl/Trp53tm1Wahl
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Wahl mutation (0 available); any Trp53 mutation (243 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:64367 , J:100189 )
• MEFs do not arrest like wild-type and continue to cycle in response to gamma-irradiation or nucleotide pool depletion via PALA, an inhibitor of aspartate transcarbamylase (low G1/S ratio) (J:64367)
• embryonic fibroblasts from Trp53-deficient mice display a lack of cell cycle arrest upon exposure to increasing doses of ionizing radiation (J:100189)
decreased cellular sensitivity to gamma-irradiation ( J:64367 )
• MEFs do not arrest like wild-type and continue to cycle in response to gamma-irradiation
• less than 1% of thymocytes from irradiated mutants undergo apoptosis compared to 35-60% of wild-type thymocytes
increased fibroblast proliferation ( J:64367 )
• MEFs continue to proliferate past the point when normal MEFs undergo replicative senescence




Genotype
MGI:3625173
hm2
Allelic
Composition		 Trp53tm1Wahl/Trp53tm1Wahl
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Wahl mutation (0 available); any Trp53 mutation (243 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased fibroblast apoptosis ( J:108183 )
• MEFs sensitized to apoptosis by E1A overexpression show very low levels of apoptosis induced by irradiation or chemical treatment compared to wild-type or Trp53tm1Wahl MEFs

neoplasm
increased tumor incidence ( J:108183 )
• knockouts spontaneously develop fatal tumors by 10 months of age




Genotype
MGI:3625182
cx3
Allelic
Composition		 Mdm2tm1Glo/Mdm2+
Mdm4Gt(VICTR20)7Lex/Mdm4+
Trp53tm1Wahl/Trp53tm1Wahl
Genetic
Background		 involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Mdm4Gt(VICTR20)7Lex mutation (0 available); any Mdm4 mutation (193 available)
Trp53tm1Wahl mutation (0 available); any Trp53 mutation (243 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:108183 )
• presence of one copy of Mdm2 partially restores the arrest response of Trp53tm1Wahl; p21 protein levels are increased slightly more compared to homozygous Trp53tm1Wahl, Mdm2tm1Glo/+ or homozygous Trp53tm1Wahl, Mdm4/+ heterozygotes




Genotype
MGI:3625172
cx4
Allelic
Composition		 Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Trp53tm1Wahl/Trp53tm1Wahl
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4Gt(VICTR20)7Lex mutation (0 available); any Mdm4 mutation (193 available)
Trp53tm1Wahl mutation (0 available); any Trp53 mutation (243 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:108183 )
• in double homozygous MEFs, irradiation did result in cell cycle arrest, but less efficiently than in wild-type cells; p21 protein levels are the highest of all the Trp53tm1Wahl mutants analyzed
decreased cell proliferation ( J:108183 )
• loss of Mdm4 expression reduces the proliferation rate of Trp53tm1Wahl-deficient cells




Genotype
MGI:3625181
cx5
Allelic
Composition		 Mdm4Gt(VICTR20)7Lex/Mdm4+
Trp53tm1Wahl/Trp53tm1Wahl
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4Gt(VICTR20)7Lex mutation (0 available); any Mdm4 mutation (193 available)
Trp53tm1Wahl mutation (0 available); any Trp53 mutation (243 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:108183 )
• presence of one copy of Mdm2 partially restores the arrest response of Trp53tm1Wahl; p21 protein levels are modestly increased from homozygous Trp53tm1Wahl mutant levels




Genotype
MGI:3625170
cx6
Allelic
Composition		 Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm1Wahl/Trp53tm1Wahl
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Trp53tm1Wahl mutation (0 available); any Trp53 mutation (243 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:108183 )
• no double homozygotes survive to birth




Genotype
MGI:3625179
cx7
Allelic
Composition		 Mdm2tm1Glo/Mdm2+
Trp53tm1Wahl/Trp53tm1Wahl
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Trp53tm1Wahl mutation (0 available); any Trp53 mutation (243 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:108183 )
• presence of one copy of Mdm2 partially restores the arrest response of Trp53tm1Wahl; p21 protein levels are modestly increased from homozygous Trp53 mutant levels




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory