All Phenotypes Trp53<tm1Wahl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trp53^tm1Wahl
targeted mutation 1, Geoffrey M Wahl
MGI:1927802

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm1Wahl/Trp53^tm1Wahl	involves: 129S4/SvJae	MGI:3624330
hm2	Trp53^tm1Wahl/Trp53^tm1Wahl	involves: C57BL/6	MGI:3625173
cx3	Mdm2^tm1Glo/Mdm2⁺ Mdm4^{Gt(VICTR20)7Lex}/Mdm4⁺ Trp53^tm1Wahl/Trp53^tm1Wahl	involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6	MGI:3625182
cx4	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex} Trp53^tm1Wahl/Trp53^tm1Wahl	involves: 129S5/SvEvBrd * C57BL/6	MGI:3625172
cx5	Mdm4^{Gt(VICTR20)7Lex}/Mdm4⁺ Trp53^tm1Wahl/Trp53^tm1Wahl	involves: 129S5/SvEvBrd * C57BL/6	MGI:3625181
cx6	Mdm2^tm1Glo/Mdm2^tm1Glo Trp53^tm1Wahl/Trp53^tm1Wahl	involves: 129S7/SvEvBrd * C57BL/6	MGI:3625170
cx7	Mdm2^tm1Glo/Mdm2⁺ Trp53^tm1Wahl/Trp53^tm1Wahl	involves: 129S7/SvEvBrd * C57BL/6	MGI:3625179

Allelic Composition	Trp53^tm1Wahl/Trp53^tm1Wahl
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1Wahl mutation (0 available); any Trp53 mutation (243 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:64367 , J:100189 )

• MEFs do not arrest like wild-type and continue to cycle in response to gamma-irradiation or nucleotide pool depletion via PALA, an inhibitor of aspartate transcarbamylase (low G1/S ratio) (J:64367)

• embryonic fibroblasts from Trp53-deficient mice display a lack of cell cycle arrest upon exposure to increasing doses of ionizing radiation (J:100189)

decreased cellular sensitivity to gamma-irradiation ( J:64367 )

• MEFs do not arrest like wild-type and continue to cycle in response to gamma-irradiation

• less than 1% of thymocytes from irradiated mutants undergo apoptosis compared to 35-60% of wild-type thymocytes

increased fibroblast proliferation ( J:64367 )

• MEFs continue to proliferate past the point when normal MEFs undergo replicative senescence

Allelic Composition	Trp53^tm1Wahl/Trp53^tm1Wahl
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1Wahl mutation (0 available); any Trp53 mutation (243 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased fibroblast apoptosis ( J:108183 )

• MEFs sensitized to apoptosis by E1A overexpression show very low levels of apoptosis induced by irradiation or chemical treatment compared to wild-type or Trp53^tm1Wahl MEFs

neoplasm

increased tumor incidence ( J:108183 )

• knockouts spontaneously develop fatal tumors by 10 months of age

Allelic Composition	Mdm2^tm1Glo/Mdm2⁺ Mdm4^{Gt(VICTR20)7Lex}/Mdm4⁺ Trp53^tm1Wahl/Trp53^tm1Wahl
Genetic Background	involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2^tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Mdm4^{Gt(VICTR20)7Lex} mutation (0 available); any Mdm4 mutation (193 available)
Trp53^tm1Wahl mutation (0 available); any Trp53 mutation (243 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:108183 )

• presence of one copy of Mdm2 partially restores the arrest response of Trp53^tm1Wahl; p21 protein levels are increased slightly more compared to homozygous Trp53^tm1Wahl, Mdm2^tm1Glo/+ or homozygous Trp53^tm1Wahl, Mdm4/+ heterozygotes

Allelic Composition	Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex} Trp53^tm1Wahl/Trp53^tm1Wahl
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^{Gt(VICTR20)7Lex} mutation (0 available); any Mdm4 mutation (193 available)
Trp53^tm1Wahl mutation (0 available); any Trp53 mutation (243 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:108183 )

• in double homozygous MEFs, irradiation did result in cell cycle arrest, but less efficiently than in wild-type cells; p21 protein levels are the highest of all the Trp53^tm1Wahl mutants analyzed

decreased cell proliferation ( J:108183 )

• loss of Mdm4 expression reduces the proliferation rate of Trp53^tm1Wahl-deficient cells

Allelic Composition	Mdm4^{Gt(VICTR20)7Lex}/Mdm4⁺ Trp53^tm1Wahl/Trp53^tm1Wahl
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:108183 )

• presence of one copy of Mdm2 partially restores the arrest response of Trp53^tm1Wahl; p21 protein levels are modestly increased from homozygous Trp53^tm1Wahl mutant levels

Allelic Composition	Mdm2^tm1Glo/Mdm2^tm1Glo Trp53^tm1Wahl/Trp53^tm1Wahl
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2^tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Trp53^tm1Wahl mutation (0 available); any Trp53 mutation (243 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:108183 )

• no double homozygotes survive to birth

Allelic Composition	Mdm2^tm1Glo/Mdm2⁺ Trp53^tm1Wahl/Trp53^tm1Wahl
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:108183 )

• presence of one copy of Mdm2 partially restores the arrest response of Trp53^tm1Wahl; p21 protein levels are modestly increased from homozygous Trp53 mutant levels

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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