Phenotypes associated with this allele

• Allele Symbol: Fgf10^tm1Wss
• Allele Name: targeted mutation 1, W Scott Simonet
• Allele ID: MGI:1927833
• Summary: 11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf10^tm1Wss/Fgf10^tm1Wss	either: (involves: 129X1/SvJ) or (involves: 129X1/SvJ * Black Swiss)	MGI:2175021
hm2	Fgf10^tm1Wss/Fgf10^tm1Wss	involves: 129X1/SvJ	MGI:3656008
hm3	Fgf10^tm1Wss/Fgf10^tm1Wss	involves: 129X1/SvJ * C57BL/6	MGI:3662843
hm4	Fgf10^tm1Wss/Fgf10^tm1Wss	involves: 129X1/SvJ * CF-1	MGI:3656036
ht5	Fgf10^tm1Wss/Fgf10^+	involves: 129 * 129X1/SvJ * BALB/c * C57BL/6	MGI:3775808
ht6	Fgf10^tm1Wss/Fgf10^+	involves: 129X1/SvJ	MGI:5816495
ht7	Fgf10^tm1Wss/Fgf10^tm1.1Sms	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ	MGI:4456411
cn8	Fgf10^tm1Wss/Fgf10^+ Fgfr2^tm2Dsn/Fgfr2^+ Tg(Pgk1-cre)1Lni/0	involves: 129 * 129X1/SvJ * BALB/c * C57BL/6	MGI:3775807
cx9	Fgf3^tm1Mrc/Fgf3^+ Fgf10^tm1Wss/Fgf10^tm1Wss	involves: 129S7/SvEvBrd * 129X1/SvJ	MGI:3662761
cx10	Fgf3^tm1Mrc/Fgf3^tm1Mrc Fgf10^tm1Wss/Fgf10^tm1Wss	involves: 129S7/SvEvBrd * 129X1/SvJ	MGI:3662759
cx11	Fgf3^tm1Mrc/Fgf3^tm1Mrc Fgf10^tm1Wss/Fgf10^+	involves: 129S7/SvEvBrd * 129X1/SvJ	MGI:3662760

Genotype
MGI:2175021

hm1

• Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss
• Genetic Background: either: (involves: 129X1/SvJ) or (involves: 129X1/SvJ * Black Swiss)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:50768 )

growth/size/body

decreased fetal size ( J:50768 )

• crown-rump lengths of E17.5 fetuses are on average 12% shorter than controls

respiratory system

abnormal lung development ( J:50768 )

impaired branching involved in bronchus morphogenesis ( J:50768 )

• initial branching of the primordial bronchi is absent

impaired branching involved in preterminal bronchiole morphogenesis ( J:50768 )

• pulmonary bronchiolar development does not occur

abnormal branching involved in trachea morphogenesis ( J:50768 )

• initial tracheal development is normal, however the trachea terminates at the level of the thymus and no main-stem bronchi or subsequent pulmonary bronchiolar and alveolar development occurs

impaired lung alveolus development ( J:50768 )

• alveolar development does not occur

absent lungs ( J:50768 )

limbs/digits/tail

absent limb buds ( J:50768 )

• complete absence of budding limbs at E9.5 and E10.5

absent limbs ( J:50768 )

absent forelimb ( J:50768 )

absent hindlimb ( J:50768 )

skeleton

abnormal pelvic girdle bone morphology ( J:50768 )

• exhibit only a rudimentary cartilaginous pelvic girdle at E18.5

embryo

absent limb buds ( J:50768 )

• complete absence of budding limbs at E9.5 and E10.5

Genotype
MGI:3656008

hm2

• Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss
• Genetic Background: involves: 129X1/SvJ

Palatal abnormalities in Fgfr2^tm1.1Dsn/Fgfr2^tm1.1Dsn and Fgf10^tm1Wss/Fgf10^tm1Wss mice

vision/eye

absent lacrimal glands ( J:64331 )

respiratory system

abnormal nasal gland morphology ( J:237227 )

• medial nasal glands are severely defective at E17.5 with truncated ducts and a reduction in branching

• maxillary sinus gland is absent

abnormal lateral nasal gland morphology ( J:237227 )

• branching of the distal lateral nasal glands is reduced at E17.5

• Steno's duct pit is not apparent at E12.5 and by E17.5, complete absence of the Steno's duct and gland (lateral nasal gland 1) is seen

reproductive system

abnormal male reproductive system morphology ( J:85295 )

♂

absent bulbourethral gland ( J:85295 )

♂ • bulbourethral does not form in mutants and in grafting experiments, the caudal urethra does not produce the bulbourethral gland

abnormal prostate gland morphology ( J:85295 )

♂ • prostatic rudiments from homozygous mice transplanted into intact male hosts grow very little, but show some signs of prostatic differentiation

♂ • wild-type hosts grafted with homozygous mutant testes show smaller growth of the dorsolateral prostate and coagulating gland

absent prostate gland ( J:85295 )

♂ • prostate is not visible at the end of gestation

absent seminal vesicle ( J:85295 )

♂ • seminal vesicle is absent in mutants and grafted mutant caudal Wolffian duct into nude mice shows very limited ability to develop into seminal vesicle

epididymal cyst ( J:85295 )

♂ • mutants in which the caudal Wolffian duct is absent exhibit a cystic epididymis

endocrine/exocrine glands

abnormal nasal gland morphology ( J:237227 )

• medial nasal glands are severely defective at E17.5 with truncated ducts and a reduction in branching

• maxillary sinus gland is absent

abnormal lateral nasal gland morphology ( J:237227 )

• branching of the distal lateral nasal glands is reduced at E17.5

• Steno's duct pit is not apparent at E12.5 and by E17.5, complete absence of the Steno's duct and gland (lateral nasal gland 1) is seen

absent lacrimal glands ( J:64331 )

absent bulbourethral gland ( J:85295 )

♂ • bulbourethral does not form in mutants and in grafting experiments, the caudal urethra does not produce the bulbourethral gland

abnormal prostate gland morphology ( J:85295 )

♂ • prostatic rudiments from homozygous mice transplanted into intact male hosts grow very little, but show some signs of prostatic differentiation

♂ • wild-type hosts grafted with homozygous mutant testes show smaller growth of the dorsolateral prostate and coagulating gland

absent prostate gland ( J:85295 )

♂ • prostate is not visible at the end of gestation

absent seminal vesicle ( J:85295 )

♂ • seminal vesicle is absent in mutants and grafted mutant caudal Wolffian duct into nude mice shows very limited ability to develop into seminal vesicle

absent Harderian gland ( J:64331 )

craniofacial

abnormal palate morphology ( J:90909 )

• palates are short, squared in shape

abnormal palatal mesenchymal cell proliferation ( J:90909 )

• mesenchymal proliferation in the palate is reduced at E12 and E13 by 12-32%

abnormal secondary palate development ( J:90909 )

• palatal epithelium is thin and lacks stratification and in some cases the epithelial covering at the tip of the palatal projection has disintegrated and the underlying mesenchymal cells have broken through into the oral cavity

• epithelial cell proliferation is reduced in all areas of the palate at E12 and E13

• mesenchymal proliferation in the palate is reduced at E12 and E13 by 12-32%

• exhibit an increase in apoptotic cells in the palate at E13

palatal shelf fusion with tongue or mandible ( J:90909 )

• exhibit epithelial fusions between the nasal surface of the palate and the tongue, as well as the oral surface of the palate and the mandible

decreased palatal length ( J:90909 )

absent palatal rugae ( J:90909 )

• absent

cleft secondary palate ( J:90909 )

• exhibit a complete, wide cleft of the secondary palate; palate abnormalities first noted at E13

• do not have finger-like projections lateral to the tongue

abnormal tongue morphology ( J:90909 )

• exhibit isolated epithelial outgrowths on the dorsal surface of the tongue

tongue ankylosis ( J:90909 )

• exhibit partial ankylosis of the tongue, with defective epithelialization between the floor of the mouth and tongue

abnormal nasal gland morphology ( J:237227 )

• medial nasal glands are severely defective at E17.5 with truncated ducts and a reduction in branching

• maxillary sinus gland is absent

abnormal lateral nasal gland morphology ( J:237227 )

• branching of the distal lateral nasal glands is reduced at E17.5

• Steno's duct pit is not apparent at E12.5 and by E17.5, complete absence of the Steno's duct and gland (lateral nasal gland 1) is seen

digestive/alimentary system

abnormal palate morphology ( J:90909 )

• palates are short, squared in shape

abnormal palatal mesenchymal cell proliferation ( J:90909 )

• mesenchymal proliferation in the palate is reduced at E12 and E13 by 12-32%

abnormal secondary palate development ( J:90909 )

• palatal epithelium is thin and lacks stratification and in some cases the epithelial covering at the tip of the palatal projection has disintegrated and the underlying mesenchymal cells have broken through into the oral cavity

• epithelial cell proliferation is reduced in all areas of the palate at E12 and E13

• mesenchymal proliferation in the palate is reduced at E12 and E13 by 12-32%

• exhibit an increase in apoptotic cells in the palate at E13

palatal shelf fusion with tongue or mandible ( J:90909 )

• exhibit epithelial fusions between the nasal surface of the palate and the tongue, as well as the oral surface of the palate and the mandible

decreased palatal length ( J:90909 )

absent palatal rugae ( J:90909 )

• absent

cleft secondary palate ( J:90909 )

• exhibit a complete, wide cleft of the secondary palate; palate abnormalities first noted at E13

• do not have finger-like projections lateral to the tongue

abnormal tongue morphology ( J:90909 )

• exhibit isolated epithelial outgrowths on the dorsal surface of the tongue

tongue ankylosis ( J:90909 )

• exhibit partial ankylosis of the tongue, with defective epithelialization between the floor of the mouth and tongue

renal/urinary system

hypospadia ( J:98380 )

• both males and females develop severe proximal hypospadias as early as E13.5

embryo

abnormal primitive urogenital sinus morphology ( J:85295 )

• homozygous urogenital sinuses do not form buds or ducts when cultured with testosterone alone as in controls and grafts of homozygous urogenital sinuses into nude mice exhibit no development of branching ducts

abnormal Wolffian duct morphology ( J:85295 )

• the entire Wolffian duct is present at E15 or before, but by E18 the caudal portion of the Wolffian duct is absent in the majority of males

• when present, the Wolffian duct is much thinner

integument

abnormal epidermal layer morphology ( J:85732 )

• exhibit mild epidermal hypoplasia, much less severe than seen in homozygous Fgfr2 mutants and do not exhibit any hair follicle defects

thin epidermis ( J:85732 )

growth/size/body

abnormal palate morphology ( J:90909 )

• palates are short, squared in shape

abnormal palatal mesenchymal cell proliferation ( J:90909 )

• mesenchymal proliferation in the palate is reduced at E12 and E13 by 12-32%

abnormal secondary palate development ( J:90909 )

• mesenchymal proliferation in the palate is reduced at E12 and E13 by 12-32%

• palatal epithelium is thin and lacks stratification and in some cases the epithelial covering at the tip of the palatal projection has disintegrated and the underlying mesenchymal cells have broken through into the oral cavity

• epithelial cell proliferation is reduced in all areas of the palate at E12 and E13

• exhibit an increase in apoptotic cells in the palate at E13

palatal shelf fusion with tongue or mandible ( J:90909 )

• exhibit epithelial fusions between the nasal surface of the palate and the tongue, as well as the oral surface of the palate and the mandible

decreased palatal length ( J:90909 )

absent palatal rugae ( J:90909 )

• absent

cleft secondary palate ( J:90909 )

• exhibit a complete, wide cleft of the secondary palate; palate abnormalities first noted at E13

• do not have finger-like projections lateral to the tongue

abnormal tongue morphology ( J:90909 )

• exhibit isolated epithelial outgrowths on the dorsal surface of the tongue

tongue ankylosis ( J:90909 )

• exhibit partial ankylosis of the tongue, with defective epithelialization between the floor of the mouth and tongue

abnormal nasal gland morphology ( J:237227 )

• medial nasal glands are severely defective at E17.5 with truncated ducts and a reduction in branching

• maxillary sinus gland is absent

abnormal lateral nasal gland morphology ( J:237227 )

• branching of the distal lateral nasal glands is reduced at E17.5

• Steno's duct pit is not apparent at E12.5 and by E17.5, complete absence of the Steno's duct and gland (lateral nasal gland 1) is seen

epididymal cyst ( J:85295 )

♂ • mutants in which the caudal Wolffian duct is absent exhibit a cystic epididymis

Genotype
MGI:3662843

hm3

• Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss
• Genetic Background: involves: 129X1/SvJ * C57BL/6

digestive/alimentary system

abnormal cecum development ( J:104353 )

• abnormal cecum development; develop a mesenchymal bud at the ileo-colonic junction but no epithelial budding or expansion into the cecal mesenchume at E12.5

• at E14.5, show a continued mesenchymal bud with no epithelial budding which appears to degenerate by E18.5

Genotype
MGI:3656036

hm4

• Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1Wss
• Genetic Background: involves: 129X1/SvJ * CF-1

hearing/vestibular/ear

small ears ( J:83738 )

abnormal cochlea morphology ( J:83738 )

• the cochlea is shortened but otherwise normal including the organ of Corti

abnormal inner ear canal morphology ( J:83738 )

• the short canal emerging from the horizontal crista extend vertically toward the cochlea rather than horizontal, toward the posterior canal

decreased lateral semicircular canal size ( J:83738 )

• a blind-ending stub is formed instead of the horizontal canal

absent posterior semicircular canal ( J:83738 )

• complete absence of all aspects of the posterior canal system; no posterior crista, no posterior canal, and no myelinated nerve fiber to the area of the posterior canal

abnormal crista ampullaris morphology ( J:83738 )

• the anterior and horizontal cristae are much smaller and barely segregated from the utricle

absent superior semicircular canal ( J:83738 )

• the anterior canal is largely continuous with the utricle without forming a recognizable canal

abnormal inner ear vestibule morphology ( J:83738 )

abnormal vestibular hair cell kinocilium morphology ( J:83738 )

• enlarged bulbs on the kinocilia

abnormal vestibular hair cell stereociliary bundle morphology ( J:83738 )

• remaining hair cells of vestibular sensory epithelia show some aberrations in the formation of apical stereocilia

abnormal utricle morphology ( J:83738 )

• in most mutants, the utricle forms a central recess rather than a flat sheet of cells

small vestibular saccule ( J:83738 )

• the saccule shows slight dismorphogenesis, is somewhat smaller, and is in a somewhat different position, further away from the cochlea

nervous system

abnormal vestibular hair cell kinocilium morphology ( J:83738 )

• enlarged bulbs on the kinocilia

abnormal vestibular hair cell stereociliary bundle morphology ( J:83738 )

• remaining hair cells of vestibular sensory epithelia show some aberrations in the formation of apical stereocilia

abnormal sensory neuron innervation pattern ( J:83738 )

• the posterior canal sensory neurons from initially and project rather normally by E11.5 but they disappear within 2 days

craniofacial

small ears ( J:83738 )

cellular

abnormal vestibular hair cell kinocilium morphology ( J:83738 )

• enlarged bulbs on the kinocilia

growth/size/body

small ears ( J:83738 )

Genotype
MGI:3775808

ht5

• Allelic Composition: Fgf10^tm1Wss/Fgf10⁺
• Genetic Background: involves: 129 * 129X1/SvJ * BALB/c * C57BL/6

Submandibular gland is hypoplastic in Fgfr2^tm2Dsn/Fgfr2⁺ Tg(Pgk1-cre)1Lni/0, Fgf10^tm1Wss/Fgf10⁺, and Fgf10^tm1Wss/Fgf10⁺ Fgfr2^tm2Dsn/Fgfr2⁺ Tg(Pgk1-cre)1Lni/0 mice

endocrine/exocrine glands

submandibular gland hypoplasia ( J:119849 )

digestive/alimentary system

submandibular gland hypoplasia ( J:119849 )

Genotype
MGI:5816495

ht6

• Allelic Composition: Fgf10^tm1Wss/Fgf10⁺
• Genetic Background: involves: 129X1/SvJ

endocrine/exocrine glands

abnormal nasal gland morphology ( J:237227 )

• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5

abnormal lateral nasal gland morphology ( J:237227 )

• branching of the lateral nasal glands is reduced at E17.5

• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced

abnormal sublingual gland morphology ( J:299375 )

• sublingual gland weight is decreased in 7-10-week old mice

• sublingual glands exhibit smaller glandular lobes in 7-10-week old mice

• however, glands show no morphological differences in histology

abnormal submandibular gland development ( J:299375 )

• mice show a delay in submandibular gland development

• E12.5 explant culture of submandibular glands show smaller epithelial prebud-like invaginations of the epithelium and this delay in development continues with reduced branching

• at E14.5, the epithelium fails to invade the most aboral part of the mesenchymal capsule in culture

• the epithelium of the mesenchymal capsule of the submandibular gland is less developed at E14.5, with fewer branches, larger epithelial buds and more extensive areas of mesenchyme not invaded by the epithelium

decreased submandibular gland size ( J:299375 )

• submandibular gland and sublingual gland weight is decreased in 7-10-week old mice

• submandibular glands exhibit smaller glandular lobes in 7-10-week old mice

• however, glands show no morphological differences in histology

small salivary gland ( J:299375 )

• the overall size of salivary gland lobes appears smaller and weight is reduced at P14

• males have larger glands compared to females

decreased salivation ( J:299375 )

• mice show a reduction in saliva flow from both the submandibular gland and parotid gland

• mice show a reduction in the salivary pellicle on the tongue; mice treated with HCl to remove the mucus from the oral surface show complete removal of mucus unlike wild-type mice that show sheets of mucus remaining

xerostomia ( J:299375 )

behavior/neurological

polydipsia ( J:299375 )

craniofacial

reduced enamel thickness ( J:299375 )

• mice exhibit less enamel than controls and teeth of many mice show severe tooth wear, with almost complete loss of the cusp pattern in the most severe cases, due to reduced saliva

xerostomia ( J:299375 )

abnormal nasal gland morphology ( J:237227 )

• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5

abnormal lateral nasal gland morphology ( J:237227 )

• branching of the lateral nasal glands is reduced at E17.5

• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced

digestive/alimentary system

abnormal sublingual gland morphology ( J:299375 )

• sublingual gland weight is decreased in 7-10-week old mice

• sublingual glands exhibit smaller glandular lobes in 7-10-week old mice

• however, glands show no morphological differences in histology

abnormal submandibular gland development ( J:299375 )

• mice show a delay in submandibular gland development

• E12.5 explant culture of submandibular glands show smaller epithelial prebud-like invaginations of the epithelium and this delay in development continues with reduced branching

• at E14.5, the epithelium fails to invade the most aboral part of the mesenchymal capsule in culture

• the epithelium of the mesenchymal capsule of the submandibular gland is less developed at E14.5, with fewer branches, larger epithelial buds and more extensive areas of mesenchyme not invaded by the epithelium

decreased submandibular gland size ( J:299375 )

• submandibular gland and sublingual gland weight is decreased in 7-10-week old mice

• submandibular glands exhibit smaller glandular lobes in 7-10-week old mice

• however, glands show no morphological differences in histology

small salivary gland ( J:299375 )

• males have larger glands compared to females

• the overall size of salivary gland lobes appears smaller and weight is reduced at P14

decreased salivation ( J:299375 )

• mice show a reduction in saliva flow from both the submandibular gland and parotid gland

• mice show a reduction in the salivary pellicle on the tongue; mice treated with HCl to remove the mucus from the oral surface show complete removal of mucus unlike wild-type mice that show sheets of mucus remaining

xerostomia ( J:299375 )

growth/size/body

reduced enamel thickness ( J:299375 )

• mice exhibit less enamel than controls and teeth of many mice show severe tooth wear, with almost complete loss of the cusp pattern in the most severe cases, due to reduced saliva

xerostomia ( J:299375 )

abnormal nasal gland morphology ( J:237227 )

• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5

abnormal lateral nasal gland morphology ( J:237227 )

• branching of the lateral nasal glands is reduced at E17.5

• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced

homeostasis/metabolism

decreased salivation ( J:299375 )

• mice show a reduction in saliva flow from both the submandibular gland and parotid gland

• mice show a reduction in the salivary pellicle on the tongue; mice treated with HCl to remove the mucus from the oral surface show complete removal of mucus unlike wild-type mice that show sheets of mucus remaining

xerostomia ( J:299375 )

respiratory system

abnormal nasal gland morphology ( J:237227 )

• branching of the maxillary sinus gland, lateral nasal glands, and medial nasal glands is reduced at E17.5

abnormal lateral nasal gland morphology ( J:237227 )

• branching of the lateral nasal glands is reduced at E17.5

• at E17.5, the Steno's gland (lateral nasal gland 1) is developed and elongates to the correct location under the maxillary sinus, however, the extent of branching is reduced

skeleton

reduced enamel thickness ( J:299375 )

• mice exhibit less enamel than controls and teeth of many mice show severe tooth wear, with almost complete loss of the cusp pattern in the most severe cases, due to reduced saliva

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lacrimoauriculodentodigital syndrome 1		DOID:0050331	OMIM:149730	J:237227

Genotype
MGI:4456411

ht7

• Allelic Composition: Fgf10^tm1Wss/Fgf10^tm1.1Sms
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ

embryo

abnormal embryo development ( J:160254 )

• authors state that mice are indistinguishable from mice homozygous for other Fgf10 null alleles

hearing/vestibular/ear

abnormal ear morphology ( J:160254 )

• authors state that mice are indistinguishable from mice homozygous for other Fgf10 null alleles

respiratory system

abnormal respiratory system morphology ( J:160254 )

• authors state that mice are indistinguishable from mice homozygous for other Fgf10 null alleles

Genotype
MGI:3775807

cn8

• Allelic Composition: Fgf10^tm1Wss/Fgf10⁺; Fgfr2^tm2Dsn/Fgfr2⁺; Tg(Pgk1-cre)1Lni/0
• Genetic Background: involves: 129 * 129X1/SvJ * BALB/c * C57BL/6

Submandibular gland is hypoplastic in Fgfr2^tm2Dsn/Fgfr2⁺ Tg(Pgk1-cre)1Lni/0, Fgf10^tm1Wss/Fgf10⁺, and Fgf10^tm1Wss/Fgf10⁺ Fgfr2^tm2Dsn/Fgfr2⁺ Tg(Pgk1-cre)1Lni/0 mice

endocrine/exocrine glands

abnormal submandibular duct morphology ( J:119849 )

• submandibular salivary glands exhibit fewer ducts and terminal buds than either single heterozygous mutant

decreased submandibular gland size ( J:119849 )

• submandibular salivary glands are smaller than either single heterozygous mutant

digestive/alimentary system

abnormal submandibular duct morphology ( J:119849 )

• submandibular salivary glands exhibit fewer ducts and terminal buds than either single heterozygous mutant

decreased submandibular gland size ( J:119849 )

• submandibular salivary glands are smaller than either single heterozygous mutant

Genotype
MGI:3662761

cx9

• Allelic Composition: Fgf3^tm1Mrc/Fgf3⁺; Fgf10^tm1Wss/Fgf10^tm1Wss
• Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

hearing/vestibular/ear

small otic vesicle ( J:83659 )

• small otic vesicles at E9.5; phenotype is not as severe as in mutants homozygous for Fgf3 and heterozygous for Fgf10

Genotype
MGI:3662759

cx10

• Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc; Fgf10^tm1Wss/Fgf10^tm1Wss
• Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

hearing/vestibular/ear

absent otic vesicle ( J:83659 )

• embryos either have a unilateral microvesicle or lack any sign of otic vesicle formation

absent inner ear ( J:83659 )

• otic development arrests prior to invagination of the otic cup to form the otic vesicle

limbs/digits/tail

absent limbs ( J:83659 )

short tail ( J:83659 )

curly tail ( J:83659 )

• E10.5 embryos have short dorsally curved tails

Genotype
MGI:3662760

cx11

• Allelic Composition: Fgf3^tm1Mrc/Fgf3^tm1Mrc; Fgf10^tm1Wss/Fgf10⁺
• Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

hearing/vestibular/ear

abnormal otic vesicle development ( J:83659 )

• otic vesicles are more ventrally localized than in controls

small otic vesicle ( J:83659 )

• small otic vesicles at E9.5; phenotype is more severe than in mutants homozygous for Fgf10 and heterozygous for Fgf3