Phenotypes associated with this allele

• Allele Symbol: Hoxb1^tm5Mrc
• Allele Name: targeted mutation 5, Mario R Capecchi
• Allele ID: MGI:1928090
• Summary: 10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxb1^tm5Mrc/Hoxb1^tm5Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2175215
hm2	Hoxb1^tm5Mrc/Hoxb1^tm5Mrc	Not Specified	MGI:3038606
ht3	Hoxb1^tm5Mrc/Hoxb1^tm8(Hoxa1)Mrc	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3703020
ht4	Hoxb1^tm5Mrc/Hoxb1^tm9Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3703047
cn5	Hoxb1^tm5Mrc/Hoxb1^tm7Mrc Tfap2a^tm1(cre)Moon/Tfap2a^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3050415
cn6	Hoxb1^tm5Mrc/Hoxb1^tm7Mrc H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	Not Specified	MGI:3050407
cx7	Hoxa1^tm3.1Mrc/Hoxa1^tm4(Hoxb1)Mrc Hoxb1^tm5Mrc/Hoxb1^tm8(Hoxa1)Mrc	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3703012
cx8	Hoxa1^tm4(Hoxb1)Mrc/Hoxa1^tm4(Hoxb1)Mrc Hoxb1^tm5Mrc/Hoxb1^tm8(Hoxa1)Mrc	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3703016
cx9	Hoxa1^tm5Mrc/Hoxa1^tm5Mrc Hoxb1^tm5Mrc/Hoxb1^tm5Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3703022
cx10	Hoxa1^tm5Mrc/Hoxa1^+ Hoxb1^tm5Mrc/Hoxb1^tm5Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3703018

Genotype
MGI:2175215

hm1

• Allelic Composition: Hoxb1^tm5Mrc/Hoxb1^tm5Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

absent facial nuclei ( J:119279 )

• facial nucleus is absent in brainstem

absent facial nerve ( J:119279 )

• facial nerve is absent in brainstem

Genotype
MGI:3038606

hm2

• Allelic Composition: Hoxb1^tm5Mrc/Hoxb1^tm5Mrc
• Genetic Background: Not Specified

nervous system

decreased sensory neuron number ( J:88581 )

• absence of noradrenergic visceral sensory interneurons and associated expansion of the somatic sensory interneuron domain in rhombomere 4

Genotype
MGI:3703020

ht3

• Allelic Composition: Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:119279 )

• mutants are indistinguishable from wild-type

Genotype
MGI:3703047

ht4

• Allelic Composition: Hoxb1^tm5Mrc/Hoxb1^tm9Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

behavior/neurological

abnormal reflex ( J:119279 )

• 20% of mutants show a mild form of incomplete eyelid closure in response to stimulus

Genotype
MGI:3050415

cn5

• Allelic Composition: Hoxb1^tm5Mrc/Hoxb1^tm7Mrc; Tfap2a^tm1(cre)Moon/Tfap2a⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

behavior/neurological

behavior/neurological phenotype ( J:91364 )

N • no behavioral abnormalities are seen

nervous system

decreased motor neuron number ( J:91364 )

• the average number of motor neurons is significantly reduced in mutants compared to wild-type mice although not to the same extent as in compound heterozygous mutants carrying Tg(Wnt1-cre)11Rth

Genotype
MGI:3050407

cn6

• Allelic Composition: Hoxb1^tm5Mrc/Hoxb1^tm7Mrc; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: Not Specified

behavior/neurological

abnormal reflex ( J:91364 )

• some mutants are unable to move their ears

abnormal blinking ( J:91364 )

• some mutants are unable to blink their eyes

abnormal vibrissae reflex ( J:91364 )

• some mutants are unable to move their whiskers

paralysis ( J:91364 )

• 35% of mutants show total facial paralysis and another 10% show partial facial paralysis

nervous system

decreased motor neuron number ( J:91364 )

• increased motor neuron loss is seen from E14.5 to E16.5 when motor neuron pruning normally occurs resulting a significant decrease in the average number of motor neurons in mutants compared to wild-type mice

abnormal facial nerve morphology ( J:91364 )

• loss of VII th cranial nerve branches is seen

• at E12.5 the average number of axonal branch points is decreased

Genotype
MGI:3703012

cx7

• Allelic Composition: Hoxa1^tm3.1Mrc/Hoxa1^{tm4(Hoxb1)Mrc}; Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

behavior/neurological

abnormal blinking ( J:119279 )

• facial paralysis is predominantly manifested in impaired eyeblink reflex

facial paralysis ( J:119279 )

• majority of mice show various levels of facial paralysis

Genotype
MGI:3703016

cx8

• Allelic Composition: Hoxa1^{tm4(Hoxb1)Mrc}/Hoxa1^{tm4(Hoxb1)Mrc}; Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

behavior/neurological

abnormal reflex ( J:119279 )

• eyeblink reflex is impaired in 58% of mutants; only 11% are considered to be severely affected

nervous system

abnormal facial nerve morphology ( J:119279 )

• zygomatic and temporal branches of facial nerve have normal caliber, but occasionally show atypical arborization pattern

Genotype
MGI:3703022

cx9

• Allelic Composition: Hoxa1^tm5Mrc/Hoxa1^tm5Mrc; Hoxb1^tm5Mrc/Hoxb1^tm5Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

nervous system

nervous system phenotype ( J:119279 )

N • facial motor nuclei are not markedly different from wild-type

Genotype
MGI:3703018

cx10

• Allelic Composition: Hoxa1^tm5Mrc/Hoxa1⁺; Hoxb1^tm5Mrc/Hoxb1^tm5Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

behavior/neurological

abnormal reflex ( J:119279 )

• 17% of mice have a noticeably narrower range of whisker movements on one side

• 8% have a mutant-like eyelid closure reflex in one eye

paralysis ( J:119279 )

• some facial motor hypomorphism is observed; Hoxa1 haploinsufficiency is observed

nervous system

small facial motor nucleus ( J:119279 )

• haploinsufficient presumptive facial nuclei are smaller, rounder, and located more internally than wild-type

abnormal facial nerve morphology ( J:119279 )

• zygomatic and temporal branches of facial nerve in affected mutants are thinner and sometimes atypically formed, but rarely missing