Phenotypes associated with this allele

• Allele Symbol: Grin1^tm1Blt
• Allele Name: targeted mutation 1, Horst Bluethmann
• Allele ID: MGI:1928283
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin1^tm1Blt/Grin1^tm1Blt	involves: 129P2/OlaHsd * C57BL/6	MGI:2175048

Genotype
MGI:2175048

hm1

• Allelic Composition: Grin1^tm1Blt/Grin1^tm1Blt
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased susceptibility to pharmacologically induced seizures ( J:62289 )

• less sensitive to intracerebroventricular NMDA-induced convulsions

abnormal spatial learning ( J:62289 )

• acquisition of a task in a water maze is impaired, with significantly lower escape latencies, however they achieve a similar final level of performance as controls

increased startle reflex ( J:62289 )

• significantly higher startle response to 90 and 110 dB and a lower threshold for startle reactivity

impaired coordination ( J:62289 )

• impaired motor coordination in hanging wire test, with homozygotes unable to lift hindpaws onto the wire

• reduced activity in horiontal open field test

abnormal locomotor behavior ( J:62289 )

• spend significantly more time in the center of a cage than controls

nervous system

abnormal nervous system physiology ( J:62289 )

• exhibit reduced NMDA receptor glycine affinity, but not glutamate affinity, and do not have any gross CNS abnormalities

decreased susceptibility to pharmacologically induced seizures ( J:62289 )

• less sensitive to intracerebroventricular NMDA-induced convulsions

reduced long-term potentiation ( J:62289 )

• exhibit a deficit in hippocampal theta burst-induced LTP